Brassinosteroids Plant counterparts to animal steroid hormones?
Abstract
Brassinosteroids are polyhydroxylated derivatives of common plant membrane sterols such as campesterol. They occur throughout the plant kingdom and have been shown by genetic and biochemical analyses to be essential for normal plant growth and development. Numerous reviews have detailed the recent progress in our understanding of the biosynthesis, physiological responses, and molecular modes of action of brassinosteroids. It is clear that like their animal steroid counterparts, brassinosteroids have a defined receptor, can regulate the expression of specific genes, and can orchestrate complex physiological responses involved in growth. This review summarizes the current status of BR research, pointing out where appropriate the similarities and differences between the mechanism of action of brassinosteroids and the more thoroughly studied animal steroid hormones.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In plants, brassinosteroids play an essential role in plant growth and development, as well as thermotolerance.
“In plants, brassinosteroids play an essential role in plant growth and development (4–7), as well as thermotolerance (30).”
From Anabolic effect of plant brassinosteroid (2011) · cites this paper as [6]
Cites
Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571 · see citing works
The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,442 · see citing works
A Putative Leucine-Rich Repeat Receptor Kinase Involved in Brassinosteroid Signal Transduction
Li, J., & Chory, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80357-8 · Cited by 1,641 · see citing works
Dimerization of cell surface receptors in signal transduction
Heldin, C.-H. (1995) · Cell · doi:10.1016/0092-8674(95)90404-2 · Cited by 1,634 · see citing works
Nuclear Hormone Receptors and Gene Expression
Aranda, A., & Pascual, A. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1269 · Cited by 1,562 · see citing works
Ohlrogge, J., & Browse, J. (1995) · The Plant Cell · doi:10.1105/tpc.7.7.957 · Cited by 1,492 · see citing works
BRASSINOSTEROIDS: Essential Regulators of Plant Growth and Development
Clouse, S. D., & Sasse, J. M. (1998) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.49.1.427 · Cited by 1,462 · see citing works
Self-citationActive and Inactive Protein Kinases: Structural Basis for Regulation
Johnson, L. N., Noble, M. E. M., & Owen, D. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81092-2 · Cited by 1,396 · see citing works
The leucine-rich repeat: a versatile binding motif
Kobe, B., & Deisenhofer, J. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90090-6 · Cited by 1,212 · see citing works
Plant hormones : physiology, biochemistry and molecular biology
Davies, P. J. (1995) · Medical Entomology and Zoology · Cited by 1,039 · see citing works
Brassinolide, a plant growth-promoting steroid isolated from Brassica napus pollen
Grove, M. D., Spencer, G. F., Rohwedder, W. K., Mandava, N. B., Worley, J. F., Warthen, J. D., Steffens, G. L., Flippen-Anderson, J. L., & Cook, J. C. (1979) · Nature · doi:10.1038/281216a0 · Cited by 1,024 · see citing works
Szekeres, M., Németh, K., Koncz–Kálmán, Z., Mathur, J., Kauschmann, A., Altmann, T., Rédei, G. P., Nagy, F., Schell, J., & Koncz, C. (1996) · Cell · doi:10.1016/s0092-8674(00)81094-6 · Cited by 998 · see citing works
Multiple Actions of Steroid Hormones—A Focus on Rapid, Nongenomic Effects
Falkenstein, E., Tillmann, H.-C., Christ, M., Feuring, M., & Wehling, M. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01468-6 · Cited by 986 · see citing works
A Role for Brassinosteroids in Light-Dependent Development of Arabidopsis
Li, J., Nagpal, P., Vitart, V., McMorris, T. C., & Chory, J. (1996) · Science · doi:10.1126/science.272.5260.398 · Cited by 856 · see citing works
BRI1 is a critical component of a plasma-membrane receptor for plant steroids
Wang, Z.-Y., Seto, H., Fujioka, S., Yoshida, S., & Chory, J. (2001) · Nature · doi:10.1038/35066597 · Cited by 846 · see citing works
Clouse, S. D., Langford, M., & McMorris, T. C. (1996) · PLANT PHYSIOLOGY · doi:10.1104/pp.111.3.671 · Cited by 819 · see citing works
Self-citationYamamuro, C., Ihara, Y., Wu, X., Noguchi, T., Fujioka, S., Takatsuto, S., Ashikari, M., Kitano, H., & Matsuoka, M. (2000) · The Plant Cell · doi:10.1105/tpc.12.9.1591 · Cited by 758 · see citing works
SPECIFIC, NONGENOMIC ACTIONS OF STEROID HORMONES
Wehling, M. (1997) · Annual Review of Physiology · doi:10.1146/annurev.physiol.59.1.365 · Cited by 657 · see citing works
Mutations affecting body organization in the Arabidopsis embryo
Mayer, U., Ruiz, R. A. T., Berleth, T., Miséra, S., & Jürgens, G. (1991) · Nature · doi:10.1038/353402a0 · Cited by 586 · see citing works
Plant hormones. Physiology, biochemistry and molecular biology
Guardiola, J. L. (1996) · Scientia Horticulturae · doi:10.1016/s0304-4238(96)00922-3 · Cited by 586 · see citing works
MODULAR PEPTIDE RECOGNITION DOMAINS IN EUKARYOTIC SIGNALING
Kuriyan, J., & Cowburn, D. (1997) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.26.1.259 · Cited by 549 · see citing works
Plant sterols and the membrane environment
Hartmann, M.-A. (1998) · Trends in Plant Science · doi:10.1016/s1360-1385(98)01233-3 · Cited by 529 · see citing works
Plant Growth-Promoting Brassinosteroids
Mandava, N. B. (1988) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.pp.39.060188.000323 · Cited by 514 · see citing works
Cosgrove, D. J. (1997) · The Plant Cell · doi:10.1105/tpc.9.7.1031 · Cited by 506 · see citing works
Perception of Brassinosteroids by the Extracellular Domain of the Receptor Kinase BRI1
He, Z., Wang, Z., Li, J., Zhu, Q., Lamb, C. J., Ronald, P. C., & Chory, J. (2000) · Science · doi:10.1126/science.288.5475.2360 · Cited by 492 · see citing works
Choe, S., Dilkes, B. P., Fujioka, S., Takatsuto, S., Sakurai, A., & Feldmann, K. A. (1998) · The Plant Cell · doi:10.1105/tpc.10.2.231 · Cited by 484 · see citing works
Friedrichsen, D. M., Joazeiro, C. A. P., Li, J., Hunter, T. R., & Chory, J. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.123.4.1247 · Cited by 474 · see citing works
Brassinosteroid-Insensitive Dwarf Mutants of Arabidopsis Accumulate Brassinosteroids
Noguchi, T., Fujioka, S., Choe, S., Takatsuto, S., Yoshida, S., Yuan, H., Feldmann, K. A., & Tax, F. E. (1999) · PLANT PHYSIOLOGY · doi:10.1104/pp.121.3.743 · Cited by 473 · see citing works
Sterols and Isoprenoids: Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway
Edwards, P. A., & Ericsson, J. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.157 · Cited by 455 · see citing works
Tracheary Element Differentiation.
Fukuda, H. (1997) · The Plant Cell · doi:10.1105/tpc.9.7.1147 · Cited by 445 · see citing works
Trotochaud, A. E., Hao, T., Wu, G., Yang, Z., & Clark, S. E. (1999) · The Plant Cell · doi:10.1105/tpc.11.3.393 · Cited by 417 · see citing works
Brassins—a New Family of Plant Hormones from Rape Pollen
Mitchell, J. W., Mandava, N. B., Worley, J. F., Plimmer, J. R., & Smith, M. V. (1970) · Nature · doi:10.1038/2251065a0 · Cited by 401 · see citing works
Nuclear Hormone Receptor Coregulators In Action: Diversity For Shared Tasks
Robyr, D., Wolffe, A. P., & Wahli, W. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.3.0411 · Cited by 378 · see citing works
Hu, Y., Bao, F., & Li, J. (2000) · The Plant Journal · doi:10.1046/j.1365-313x.2000.00915.x · Cited by 372 · see citing works
Genetic evidence for an essential role of brassinosteroids in plant development
Kauschmann, A., Jessop, A. C., Koncz, C., Szekeres, M., Willmitzer, L., & Altmann, T. (1996) · The Plant Journal · doi:10.1046/j.1365-313x.1996.9050701.x · Cited by 353 · see citing works
Choe, S., Fujioka, S., Noguchi, T., Takatsuto, S., Yoshida, S., & Feldmann, K. A. (2001) · The Plant Journal · doi:10.1046/j.1365-313x.2001.01055.x · Cited by 340 · see citing works
The tomato DWARF enzyme catalyses C-6 oxidation in brassinosteroid biosynthesis
Bishop, G. J., Nomura, T., Yokota, T., Harrison, K., Noguchi, T., Fujioka, S., Takatsuto, S., Jones, J. D. G., & Kamiya, Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1761 · Cited by 332 · see citing works
Amino‐terminal leucine‐rich repeats in gonadotropin receptors determine hormone selectivity.
Braun, T. W., Schofield, P. R., & Sprengel, R. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07714.x · Cited by 329 · see citing works
An Arabidopsis Brassinosteroid-Dependent Mutant Is Blocked in Cell Elongation
Azpiroz, R., Wu, Y., LoCascio, J. C., & Feldmann, K. A. (1998) · The Plant Cell · doi:10.1105/tpc.10.2.219 · Cited by 318 · see citing works
Schumacher, K., Vafeados, D. K., McCarthy, M., Sze, H., Wilkins, T., & Chory, J. (1999) · Genes & Development · doi:10.1101/gad.13.24.3259 · Cited by 315 · see citing works
The Arabidopsis deetiolated2 Mutant Is Blocked Early in Brassinosteroid Biosynthesis
Fujioka, S., Li, J., Choi, Y. H., Seto, H., Takatsuto, S., Noguchi, T., Watanabe, T., Kuriyama, H., Yokota, T., Chory, J., et al. (1997) · The Plant Cell · doi:10.1105/tpc.9.11.1951 · Cited by 315 · see citing works
Structure and Properties of the Vacuolar (H+)-ATPases
Forgac, M. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.12951 · Cited by 306 · see citing works
Aquaporins: water channel proteins of plant and animal cells
Chrispeels, M. J., & Agre, P. C. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90091-4 · Cited by 305 · see citing works
The Arabidopsis DIMINUTO/DWARF1 Gene Encodes a Protein Involved in Steroid Synthesis
Klahre, U., Noguchi, T., Fujioka, S., Takatsuto, S., Yokota, T., Nomura, T., Yoshida, S., & Chua, N. (1998) · The Plant Cell · doi:10.1105/tpc.10.10.1677 · Cited by 290 · see citing works
Binding of an arm repeat protein to the kinase domain of the S -locus receptor kinase
Gu, T., Mazzurco, M., Sulaman, W., Matias, D. D., & Goring, D. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.382 · Cited by 288 · see citing works
STEROL METHYLTRANSFERASE 1 Controls the Level of Cholesterol in Plants
Diener, A. C., Li, H., Zhou, W., Whoriskey, W. J., Nes, W. D., & Fink, G. R. (2000) · The Plant Cell · doi:10.1105/tpc.12.6.853 · Cited by 288 · see citing works
Interaction of a Protein Phosphatase with an Arabidopsis Serine-Threonine Receptor Kinase
Stone, J. M., Collinge, M. A., Smith, R. D., Horn, M. A., & Walker, J. C. (1994) · Science · doi:10.1126/science.7973632 · Cited by 272 · see citing works
The structure, biosynthesis and function of brassinosteroids
Yokota, T. (1997) · Trends in Plant Science · doi:10.1016/s1360-1385(97)01017-0 · Cited by 262 · see citing works
Choe, S., Dilkes, B. P., Gregory, B. D., Ross, A. S., Yuan, H., Noguchi, T., Fujioka, S., Takatsuto, S., Tanaka, A., Yoshida, S., et al. (1999) · PLANT PHYSIOLOGY · doi:10.1104/pp.119.3.897 · Cited by 252 · see citing works
Schrick, K., Mayer, U., Horrichs, A., Kuhnt, C., Bellini, C., Dangl, J., Schmidt, J., & Jürgens, G. (2000) · Genes & Development · doi:10.1101/gad.14.12.1471 · Cited by 252 · see citing works
Brassinosteroids : steroidal plant hormones
Sakurai, A., 横田, 孝., & Clouse, S. D. (1999) · Springer eBooks · Cited by 247 · see citing works
Self-citationThe DIMINUTO gene of Arabidopsis is involved in regulating cell elongation.Preprint
Takahashi, T., Gasch, A., Nishizawa, N. K., & Chua, N. (1995) · Genes & Development · doi:10.1101/gad.9.1.97 · Cited by 239 · see citing works
Hormonal Control of the Cell Cycle in Ovarian Cells: Proliferation Versus Differentiation
Robker, R. L., & Richards, J. S. (1998) · Biology of Reproduction · doi:10.1095/biolreprod59.3.476 · Cited by 236 · see citing works
Choe, S., Noguchi, T., Fujioka, S., Takatsuto, S., Tissier, C. P., Gregory, B. D., Ross, A. S., Tanaka, A., Yoshida, S., Tax, F. E., et al. (1999) · PubMed Central · Cited by 236 · see citing works
When plant cells decide to divide
Stals, H., & Inzé, D. (2001) · Trends in Plant Science · doi:10.1016/s1360-1385(01)02016-7 · Cited by 233 · see citing works
Shimada, Y., Fujioka, S., Miyauchi, N., Kushiro, M., Takatsuto, S., Nomura, T., Yokota, T., Kamiya, Y., Bishop, G. J., & Yoshida, S. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.126.2.770 · Cited by 227 · see citing works
From seed germination to flowering, light controls plant development via the pigment phytochrome.
Chory, J., Chatterjee, M., Cook, R., Elich, T. D., Fankhauser, C., Li, J., Nagpal, P., Neff, M. M., Pepper, A. E., Poole, D. S., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12066 · Cited by 226 · see citing works
Mathur, J., Molnár, G., Fujioka, S., Takatsuto, S., Sakurai, A., Yokota, T., Adam, G., Voigt, B., Nagy, F., Maas, C., et al. (1998) · The Plant Journal · doi:10.1046/j.1365-313x.1998.00158.x · Cited by 223 · see citing works
Molecular cloning and expression of the human Δ7-sterol reductase
Moebius, F. F., Fitzky, B. U., Lee, J. N., Paik, Y., & Glossmann, H. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1899 · Cited by 221 · see citing works
Benveniste, P. (1986) · Annual Review of Plant Physiology · doi:10.1146/annurev.pp.37.060186.001423 · Cited by 220 · see citing works
The plant hormones : Their nature, occurrence, and functions
Davis, P. J. (1995) · Medical Entomology and Zoology · Cited by 219 · see citing works
Zurek, D. M., & Clouse, S. D. (1994) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.1.161 · Cited by 218 · see citing works
Self-citationA Putative Role for the Tomato Genes DUMPY and CURL-3 in Brassinosteroid Biosynthesis and Response
Koka, C. R., Cerny, R. E., Gardner, R. G., Noguchi, T., Fujioka, S., Takatsuto, S., Yoshida, S., & Clouse, S. D. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.122.1.85 · Cited by 215 · see citing works
Self-citationJang, J.-C., Fujioka, S., Tasaka, M., Seto, H., Takatsuto, S., Ishii, A., Aida, M., Yoshida, S., & Sheen, J. (2000) · Genes & Development · doi:10.1101/gad.14.12.1485 · Cited by 214 · see citing works
Membrane‐Initiated Steroid Actions and theProteins that Mediate Them
Watson, C. S., & Gametchu, B. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-2.x · Cited by 214 · see citing works
Falkenstein, E., Meyer, C., Eisen, C., Scriba, P. C., & Wehling, M. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1761 · Cited by 211 · see citing works
A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor
Chen, R., Miettinen, P. J., Maruoka, E. M., Choy, L., & Derynck, R. (1995) · Nature · doi:10.1038/377548a0 · Cited by 196 · see citing works
Yamamoto, R., Demura, T., & Fukuda, H. (1997) · Plant and Cell Physiology · doi:10.1093/oxfordjournals.pcp.a029262 · Cited by 191 · see citing works
Bower, M. S., Matias, D. D., Fernandes-Carvalho, E., Mazzurco, M., Gu, T., Rothstein, S. J., & Goring, D. R. (1996) · The Plant Cell · doi:10.1105/tpc.8.9.1641 · Cited by 190 · see citing works
Oh, M., Ray, W. K., Huber, S. C., Asara, J. M., Gage, D. A., & Clouse, S. D. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.124.2.751 · Cited by 190 · see citing works
Self-citationChoe, S., Tanaka, A., Noguchi, T., Fujioka, S., Takatsuto, S., Ross, A. S., Tax, F. E., Yoshida, S., & Feldmann, K. A. (2000) · The Plant Journal · doi:10.1046/j.1365-313x.2000.00693.x · Cited by 190 · see citing works
Gerdes, D., Wehling, M., Leube, B., & Falkenstein, E. (1998) · Biological Chemistry · doi:10.1515/bchm.1998.379.7.907 · Cited by 186 · see citing works
Kang, J., Yun, J., Kim, D., Chung, K.-S., Fujioka, S., Kim, J., Dae, H.-W., Yoshida, S., Takatsuto, S., Song, P., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00370-1 · Cited by 176 · see citing works
Noguchi, T., Fujioka, S., Takatsuto, S., Sakurai, A., Yoshida, S., Li, J., & Chory, J. (1999) · PLANT PHYSIOLOGY · doi:10.1104/pp.120.3.833 · Cited by 176 · see citing works
Catalá, C., Rose, J. K. C., & Bennett, A. B. (1997) · The Plant Journal · doi:10.1046/j.1365-313x.1997.12020417.x · Cited by 175 · see citing works
Steroid hormones and plant growth and development
Geuns, J. M. C. (1978) · Phytochemistry · doi:10.1016/s0031-9422(00)89671-5 · Cited by 169 · see citing works
Biosynthetic Pathways of Brassinolide in Arabidopsis
Noguchi, T., Fujioka, S., Choe, S., Takatsuto, S., Tax, F. E., Yoshida, S., & Feldmann, K. A. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.124.1.201 · Cited by 168 · see citing works
Conservation of function between mammalian and plant steroid 5α-reductases
Li, J., Biswas, M. G., Chao, A., Russell, D. W., & Chory, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3554 · Cited by 167 · see citing works
Iwasaki, T., & Shibaoka, H. (1991) · Plant and Cell Physiology · doi:10.1093/oxfordjournals.pcp.a078163 · Cited by 152 · see citing works
Tesarik, J., Moos, J., & Mendoza, C. (1993) · Endocrinology · doi:10.1210/endo.133.1.7686481 · Cited by 152 · see citing works
Zurek, D. M., Rayle, D. L., McMorris, T. C., & Clouse, S. D. (1994) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.2.505 · Cited by 152 · see citing works
Self-citationBrassinosteroid Levels Increase Drastically Prior to Morphogenesis of Tracheary Elements
Yamamoto, R., Fujioka, S., Demura, T., Takatsuto, S., Yoshida, S., & Fukuda, H. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.125.2.556 · Cited by 152 · see citing works
Molecular physiology of brassinosteroids revealed by the analysis of mutants
Altmann, T. (1999) · Planta · doi:10.1007/s004250050528 · Cited by 127 · see citing works
Choy, L., & Derynck, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31455 · Cited by 124 · see citing works
Falkenstein, E., Heck, M., Gerdes, D., Grube, D. F., Christ, M., Weigel, M., Buddhikot, M., Meizel, S., & Wehling, M. (1999) · Endocrinology · doi:10.1210/endo.140.12.7304 · Cited by 123 · see citing works
Brassinosteroid signal transduction: still casting the actors
Schumacher, K., & Chory, J. (2000) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(99)00038-2 · Cited by 123 · see citing works
Biosynthesis and metabolism of brassinosteroids
Fujioka, S., & Sakurai, A. (1997) · Physiologia Plantarum · doi:10.1111/j.1399-3054.1997.tb03078.x · Cited by 116 · see citing works
Membrane-Initiated Steroid Actions and the Proteins that Mediate Them
Watson, C. S., & Gametchu, B. (1999) · Experimental Biology and Medicine · doi:10.3181/00379727-220-44338 · Cited by 104 · see citing works
Pien, S., Wyrzykowska, J., & Fleming, A. J. (2001) · The Plant Journal · doi:10.1046/j.1365-313x.2001.01002.x · Cited by 101 · see citing works
Catterou, M., Dubois, F., Schaller, H., Aubanelle, L., Vilcot, B., Sangwan-Norreel, B. S., & Sangwan, R. S. (2001) · Planta · doi:10.1007/s004250000467 · Cited by 100 · see citing works
Burks, E. A., Bezerra, P. P., Le, H., Gallie, D., & Browning, K. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007236200 · Cited by 95 · see citing works
Nomura, T., Sato, T., Bishop, G. J., Kamiya, Y., Takatsuto, S., & Yokota, T. (2001) · Phytochemistry · doi:10.1016/s0031-9422(00)00440-4 · Cited by 95 · see citing works
Brassinolide may control aquaporin activities in Arabidopsis thaliana
Morillón, R., Catterou, M., Sangwan, R. S., Sangwan-Norreel, B. S., & Lassalles, J.-P. (2001) · Planta · doi:10.1007/s004250000379 · Cited by 89 · see citing works
The use of antisense mRNA to inhibit the tonoplast H+ ATPase in carrot.
Gogarten, J. P., Fichmann, J., Braun, Y., Morgan, L., Styles, P., Taiz, S. L., DeLapp, K., & Taiz, L. (1992) · The Plant Cell · doi:10.1105/tpc.4.7.851 · Cited by 89 · see citing works
An alternative brassinolide biosynthetic pathway via late C-6 oxidation
Choi, Y.-H., Fujioka, S., Nomura, T., Harada, A., Yokota, T., Takatsuto, S., & Sakurai, A. (1997) · Phytochemistry · doi:10.1016/s0031-9422(96)00572-9 · Cited by 86 · see citing works
Challenges in understanding RLK function
Lease, K. A., Ingham, E., & Walker, J. C. (1998) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(98)80261-6 · Cited by 85 · see citing works
Identification of the Major Regulatory Phosphorylation Site in Sucrose-Phosphate Synthase
McMichael, R. W., Klein, R. R., Salvucci, M. E., & Huber, S. C. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1586 · Cited by 85 · see citing works
Oh, M., Romanow, W. G., Smith, R. C., Zamski, E., Sasse, J. M., & Clouse, S. D. (1998) · Plant and Cell Physiology · doi:10.1093/oxfordjournals.pcp.a029283 · Cited by 84 · see citing works
Self-citationMendoza, C., Soler, A., & Tesařík, J. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1690 · Cited by 83 · see citing works
Brassinolide affects the rate of cell division in isolated leaf protoplasts of Petunia hybrida
Oh, M., & Clouse, S. D. (1998) · Plant Cell Reports · doi:10.1007/s002990050510 · Cited by 80 · see citing works
Self-citationMayumi, K., & Shibaoka, H. (1995) · Plant and Cell Physiology · doi:10.1093/oxfordjournals.pcp.a078734 · Cited by 79 · see citing works
Physiological actions of brassinosteroids
Sasse, J. M. (1999) · Medical Entomology and Zoology · Cited by 78 · see citing works
Molecular Analysis of Brassinolide Action in Plant Growth and Development
Clouse, S. D., & Zurek, D. M. (1991) · ACS symposium series · doi:10.1021/bk-1991-0474.ch011 · Cited by 78 · see citing works
Self-citationJiang, J., & Clouse, S. D. (2001) · The Plant Journal · doi:10.1046/j.1365-313x.2001.01007.x · Cited by 74 · see citing works
Self-citationPlant development: A role for sterols in embryogenesis
Clouse, S. D. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00639-4 · Cited by 74 · see citing works
Self-citationCatterou, M., Dubois, F., Schaller, H., Aubanelle, L., Vilcot, B., Sangwan-Norreel, B. S., & Sangwan, R. S. (2001) · Planta · doi:10.1007/s004250000466 · Cited by 72 · see citing works
Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway
Jackson, S. M., Ericsson, J., & Edwards, P. A. (1997) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4615-5901-6_1 · Cited by 71 · see citing works
Gachotte, D. J., Meens, R., & Benveniste, P. (1995) · The Plant Journal · doi:10.1046/j.1365-313x.1995.08030407.x · Cited by 65 · see citing works
Wang, T. W., Cosgrove, D. J., & Arteca, R. N. (1993) · PLANT PHYSIOLOGY · doi:10.1104/pp.101.3.965 · Cited by 64 · see citing works
Husselstein, T., Gachotte, D. J., Desprez, T., Bard, M., & Benveniste, P. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00089-0 · Cited by 57 · see citing works
Molecular genetic analysis of brassinosteroid action
Clouse, S. D. (1997) · Physiologia Plantarum · doi:10.1111/j.1399-3054.1997.tb03077.x · Cited by 56 · see citing works
Self-citationNakajima, N., 志田, 篤., & Tôyama, S. (1996) · Japanese Journal of Crop Science · doi:10.1626/jcs.65.114 · Cited by 55 · see citing works
Kawata, S., Trzaskos, J. M., & Gaylor, J. L. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88825-1 · Cited by 50 · see citing works
Toroser, D., & Huber, S. C. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0740 · Cited by 48 · see citing works
Griffiths, P. G., Sasse, J. M., Yokota, T., & Cameron, D. W. (1995) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.59.956 · Cited by 48 · see citing works
Husselstein, T., Schaller, H., Gachotte, D. J., & Benveniste, P. (1999) · Plant Molecular Biology · doi:10.1023/a:1006113919172 · Cited by 46 · see citing works
Fujioka, S., Choi, Y.-H., Takatsuto, S., Yokota, T., Li, J., Chory, J., & Sakurai, A. (1996) · Plant and Cell Physiology · doi:10.1093/oxfordjournals.pcp.a029074 · Cited by 45 · see citing works
Studies on the Δ5-Desaturation in Ergosterol Biosynthesis in Yeast
Osumi, T., Nishino, T., & Katsuki, H. (1979) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a132396 · Cited by 42 · see citing works
The Role of Cytochrome b5in 4α-Methyl-Oxidation and C5(6) Desaturation of Plant Sterol Precursors
Rahier, A., Smith, M., & Taton, M. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6974 · Cited by 36 · see citing works
Tominaga, R., Sakurai, N., & Kuraishi, S. (1994) · Plant and Cell Physiology · doi:10.1093/oxfordjournals.pcp.a078700 · Cited by 26 · see citing works
Choe, S., Dilkes, B. P., Fujioka, S., Takatsuto, S., Sakurai, A., & Feldmann, K. A. (1998) · The Plant Cell · doi:10.2307/3870701 · Cited by 22 · see citing works
U.S. Department of Agriculture Brassins Project: 1970—1980
Steffens, G. L. (1991) · ACS symposium series · doi:10.1021/bk-1991-0474.ch001 · Cited by 21 · see citing works
Cell lineage, cell signaling and the control of plant morphogenesis
Irish, V. F., & Jenik, P. D. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00213-6 · Cited by 20 · see citing works
The Use of Antisense mRNA to Inhibit the Tonoplast H + ATPase in Carrot
Gogarten, J. P., Fichmann, J., Braun, Y., Morgan, L., Styles, P., Taiz, S. L., DeLapp, K., & Taiz, L. (1992) · The Plant Cell · doi:10.2307/3869400 · Cited by 11 · see citing works
Stein, G. S., van Wijnen, A. J., Stein, J. L., Lian, J. B., McNeil, S. M., & Pockwinse, S. M. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(1999)75:32+ · Cited by 9 · see citing works
Sorauf, J. E. (1988) · Science · doi:10.1126/science.240.4852.667 · Cited by 2 · see citing works
Flagged first, then by citations
8 of the 134 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
PP2A activates brassinosteroid-responsive gene expression and plant growth by dephosphorylating BZR1
Tang, W., Yuan, M., Wang, R., Yang, Y., Wang, C., Osés-Prieto, J. A., Kim, T., Zhou, H., Deng, Z., Gampala, S. S. L., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2151 · Cited by 499 · see citing works
Grapes on Steroids. Brassinosteroids Are Involved in Grape Berry Ripening
Symons, G. M., Davies, C., Shavrukov, Y. N., Dry, I. B., Reid, J. B., & Thomas, M. R. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.070706 · Cited by 378 · see citing works
Symons, G. M., & Reid, J. B. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.043034 · Cited by 191 · see citing works
Samuel, M. A., Mudgil, Y., Salt, J. N., Delmas, F., Ramachandran, S., Chilelli, A., & Goring, D. R. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.123380 · Cited by 174 · see citing works
Mitotic and Postmitotic Senescence in Plants
Gan, S. (2003) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2003.38.re7 · Cited by 95 · see citing works
Saravanan, R. S., Slabaugh, E., Singh, V. R., Lapidus, L. J., Haas, T. A., & Brandizzí, F. (2009) · The Plant Journal · doi:10.1111/j.1365-313x.2009.03815.x · Cited by 78 · see citing works
Evolution of growth-promoting plant hormones
Ross, J. J., & Reid, J. B. (2010) · Functional Plant Biology · doi:10.1071/fp10063 · Cited by 76 · see citing works
Khripach, V. A., Zhabinskii, V. N., & Khripach, N. B. (2003) · Springer eBooks · doi:10.1007/978-94-017-0948-4_9 · Cited by 66 · see citing works
Molecular Mechanisms of Brassinosteroid-Mediated Responses to Changing Environments in Arabidopsis
Lv, M., & Li, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082737 · Cited by 58 · see citing works
Anabolic effect of plant brassinosteroid
Esposito, D., Komarnytsky, S., Shapses, S., & Raskin, I. (2011) · The FASEB Journal · doi:10.1096/fj.11-181271 · Cited by 44 · see citing works
Lima, M. D. R., Barros, U. D. O., Batista, B. L., & Lobato, A. K. D. S. (2018) · Trees · doi:10.1007/s00468-018-1743-7 · Cited by 38 · see citing works
Wu, X., Knapp, S., Stamp, A. L., STAMMERS, D. K., Jörnvall, H., Dellaporta, S. L., & Oppermann, U. C. T. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05642.x · Cited by 38 · see citing works
Oxysterol binding proteins (OSBPs) and their encoding genes in Arabidopsis and rice
Umate, P. (2011) · Steroids · doi:10.1016/j.steroids.2011.01.007 · Cited by 38 · see citing works
3-Keto-22-epi-28-nor-cathasterone, a brassinosteroid-related metabolite from Cystoseira myrica
Hamdy, A. A., Aboutabl, E. A., Sameer, S., Hussein, A. A., Díaz‐Marrero, A. R., Dárias, J., & Cueto, M. (2009) · Steroids · doi:10.1016/j.steroids.2009.06.008 · Cited by 38 · see citing works
dos Santos, L. R., Paula, L. D. S., Pereira, Y. C., da Silva, B. R. S., Batista, B. L., Alsahli, A. A., & Lobato, A. K. D. S. (2020) · Journal of Plant Growth Regulation · doi:10.1007/s00344-020-10232-y · Cited by 36 · see citing works
Pereira-Netto, A. B., Roessner, U., Fujioka, S., Bacic, A., Asami, T., Yoshida, S., & Clouse, S. D. (2009) · Tree Physiology · doi:10.1093/treephys/tpn052 · Cited by 23 · see citing works
Self-citationXue, S., Zou, J., Liu, Y., Wang, M., Zhang, C., & Le, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092339 · Cited by 23 · see citing works
Esposito, D., Rathinasabapathy, T., Poulev, A., Komarnytsky, S., & Raskin, I. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200028h · Cited by 22 · see citing works
Zahid, A., Jaber, R., Laggoun, F., Lehner, A., Rémy‐Jouet, I., Pamlard, O., Beaupierre, S., Leprince, J., Follet‐Gueye, M., Vicré‐Gibouin, M., et al. (2017) · Planta · doi:10.1007/s00425-017-2755-z · Cited by 16 · see citing works
INTERACTION OF LIGHT AND HORMONE SIGNALLING TO MEDIATE PHOTOMORPHOGENESIS
Neff, M. M., Street, I. H., Turk, E. M., & Ward, J. (2006) · Springer eBooks · doi:10.1007/1-4020-3811-9_21 · Cited by 16 · see citing works
Hypoglycemic effects of brassinosteroid in diet-induced obese mice
Esposito, D., Kizelsztein, P., Komarnytsky, S., & Raskin, I. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00024.2012 · Cited by 14 · see citing works
Xu, F., Luan, L.-Y., Zhang, Z., Huo, S.-S., Gao, X., Fang, Y., & Xi, Z. (2014) · Molecules · doi:10.3390/molecules190710189 · Cited by 14 · see citing works
The BES1/BZR1 family transcription factor as critical regulator of plant stress resilience
Li, L., Mu, T., Zhang, R., Zhang, G., Lv, J. C., Liu, Z., Luo, S., & Yu, J. (2024) · Plant Stress · doi:10.1016/j.stress.2024.100730 · Cited by 11 · see citing works
Characterization of Endogenous Levels of Brassinosteroids and Related Genes in Grapevines
Parada, F., Oklešťková, J., & Arce‐Johnson, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031827 · Cited by 10 · see citing works
Metabolic Conversion of Castasterone and Brassinolide into Their Glucosides in Higher Plants
Soeno, K., Fujioka, S., Hiranuma, S., Seto, H., & Yoshida, S. (2006) · Journal of Plant Growth Regulation · doi:10.1007/s00344-006-0005-x · Cited by 10 · see citing works
Hormone Distribution and Transport
Ross, J. J., Symons, G. M., Abas, L., Reid, J. B., & Luschnig, C. (2006) · Wiley eBooks · doi:10.1002/9780470988800.ch9 · Cited by 10 · see citing works
Galigniana, M. D., & Pilipuk, G. P. (2004) · Vitamins and hormones · doi:10.1016/s0083-6729(04)69002-9 · Cited by 6 · see citing works
Genomic and non-genomic events involved in the brassinosteroid-promoted plant cell growth
Pereira-Netto, A. B. (2010) · Springer eBooks · doi:10.1007/978-94-007-0189-2_8 · Cited by 5 · see citing works
Trautwein, E. A., & Duchateau, G. S. M. J. E. (2005) · Nutrition and disease prevention · doi:10.1201/9781420026399.pt4 · Cited by 4 · see citing works
Zhang, X., Chen, K., Zhang, Q., Wang, W., Liu, G., & Jiang, J. (2025) · Physiologia Plantarum · doi:10.1111/ppl.70080 · Cited by 3 · see citing works
Zhao, R., Zhang, Z., Liu, F., Xing, Q., Xu, N., Yan, W., & Gao, X. (2025) · Aquaculture · doi:10.1016/j.aquaculture.2025.742515 · Cited by 1 · see citing works
Yaprak Senesensi: Fizyolojik ve Moleküler Düzenlenmesine Bakış
Sağlam, N. G. (2015) · International Journal of Advances in Engineering and Pure Sciences · doi:10.7240/mufbed.73178 · Cited by 1 · see citing works
Aldosterone Receptors and Their Renal Effects: Molecular Biology and Gene Regulation
Gómez-Sánchez, C. E., Gómez-Sánchez, E. P., & Galigniana, M. D. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-373870-7.00022-3 · Cited by 1 · see citing works
Effect of Growth Regulators in Production and Rooting of Coffea arabica L. Minicuttings
Filho, P. F. M. C., Baitelle, D. C., Freitas, S. D. J., da Silva, W. S., dos Santos, P. C., Rodrigues, W. P., Freitas, S. D. P., Júnior, I. F. F., Locatelli, T., Filho, A. C. V., et al. (2018) · American Journal of Plant Sciences · doi:10.4236/ajps.2018.94049 · Cited by 1 · see citing works
Demirer, G. S., Gibson, D. J., Yue, X., Pan, K., Elishav, E., Khandal, H., Horev, G., Tarkowská, D., Cantó‐Pastor, A., Kong, S., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.21.508943 · Cited by 1 · see citing works
Hormone Distribution and Transport
Ross, J. J., Symons, G. M., Abas, L., Reid, J. B., & Luschnig, C. (2017) · Wiley eBooks · doi:10.1002/9781119312994.apr0250
Gutiérrez‐Rebolledo, G. A., Pérez-González, M. Z., Sánchez‒Ramos, M., & Cruz‐Sosa, F. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-23998-4.00010-5
Role of Brassinosteroids in Berry Quality: A Case of Three Table Grape Cultivars
Karabulut, S. A., & Altıncı, N. T. (2025) · HortScience · doi:10.21273/hortsci18952-25
- Authors
- Clouse, S. D.
- Affiliations
- North Carolina State University (US)
- Corresponding author
- Clouse, Steven D
- Venue
- Vitamins & Hormones
- Publisher
- Elsevier
- Published
- 2002
- Volume
- 65
- Pages
- 195-223
- ISSN
- 0083-6729 (ISSN-L)
- OpenAlex
- W1550083831
- Cited by
- 40
- References
- 134
- Citations by year
- 2025: 4 · 2024: 1 · 2022: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 3.09
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Vitamins and hormones (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Reproductive Biology
- Keywords
- brassinosteroids, plant steroid hormones, campesterol, brassinosteroid biosynthesis, brassinosteroid receptor, gene expression regulation, plant growth and development, plant hormone signaling
- MeSH terms
- Animals, Cell Differentiation, Cell Division, Cholestanols, Cholesterol, Mevalonic Acid, Phytosterols, Plants, Squalene, Steroids, Steroids, Heterocyclic, Triterpenes, Signal Transduction, Brassinosteroids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review