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Cited by 115Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Striatal dopamine sensitization to d-amphetamine in periadolescent but not in adult rats

Laviola, Giovanni, Pascucci, Tiziana, Pieretti, Stefano·2001·Pharmacology Biochemistry and Behavior
DOI 10.1016/s0091-3057(00)00430-5
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Abstract

The neurobiological and behavioral facets of adolescence have been poorly investigated in relation to the vulnerability to psychostimulants. Periadolescent (33-43 days) and adult (>70 days) Sprague-Dawley rats underwent a 3-day treatment history with D-amphetamine (AMPH) at 0, 2, or 10 mg/kg (once a day). After a short 5-day-long withdrawal interval, freely moving animals were challenged with a 2-mg/kg AMPH dose and their behavior as well as in vivo intrastriatum dopamine (DA) release in the CNS were assessed. Microdialysis data indicated that AMPH-history periadolescent rats showed a prominent sensitization of AMPH-stimulated DA release, whereas no such change was found in adult subjects. As expected, acute AMPH administration strongly reduced time spent lying still and increased levels of cage exploration in animals of both ages. A treatment history of high AMPH dosage was associated with a marked sensitization of the exploratory behavior in adults, whereas it induced a quite opposite profile in periadolescents. The latter group only was also characterized by a compulsive involvement in the stereotyped head-bobbing response. These results indicate that differently from adults, marked alterations in neurobiological target mechanisms are observed in rats around periadolescence as a consequence of a quite mild regimen of intermittent AMPH exposure. Thus, a neurobiological substrate for an age-related increased vulnerability towards the addictive risks of these drugs is suggest…

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Crossref · 10.1016/s0091-3057(00)00430-5

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  • The incentive processing system undergoes dramatic remodeling in early adolescence, particularly with respect to the distribution and density of dopamine receptors.

    “The incentive processing system evinces dramatic remodeling in early adolescence, particularly with respect to the distribution and density of dopamine receptors (Laviola, Pascucci & Pieretti, 2001).”

    From Peers increase adolescent risk taking by enhancing activity in the brain’s reward circuitry (2011) · cites this paper as Laviola, Pascucci & Pieretti, 2001

  • The early adolescent period is uniquely sensitive to the effects of nicotine as compared to late adolescence and adulthood.

    “Another key feature of the adolescent effects of nicotine, as seen in animal studies, is the unique sensitivity of the early adolescent period as compared to late adolescence and adulthood (Laviola et al. 2001; Cao et al. 2010; Dao et al. 2011; Kawai et al. 2011).”

    From <scp>N</scp> icotine and the adolescent brain (2015) · cites this paper as Laviola et al. 2001

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Authors
Laviola, G., Pascucci, T., & Pieretti, S.
Affiliations
Istituto Superiore di Sanità (IT)
ORCID
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2001-01
Volume
68
Issue
1
Pages
115-124
ISSN
0091-3057 (ISSN-L)
DOI
10.1016/s0091-3057(00)00430-5
OpenAlex
W2054090847
Cited by
115
References
1
Citations by year
2025: 1 · 2022: 6 · 2021: 3 · 2020: 2 · 2018: 12 · 2017: 4 · 2016: 7 · 2015: 4 · 2014: 5 · 2013: 12 · 2012: 7
FWCI
2.21
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
dopamine sensitization, d-amphetamine, periadolescence, adolescence, striatum, age differences, dopamine release, exploratory behavior, drug addiction risk, microdialysis
MeSH terms
Aging, Animals, Behavior, Animal, Body Weight, Brain Chemistry, Caudate Nucleus, Chromatography, High Pressure Liquid, Dextroamphetamine, Dopamine, Dose-Response Relationship, Drug, Exploratory Behavior, Female, Homovanillic Acid, Pregnancy, Putamen, Stereotyped Behavior, 3,4-Dihydroxyphenylacetic Acid, Neostriatum, Rats, Sprague-Dawley, Microdialysis, Dopamine Uptake Inhibitors, Rats

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