Effects of dopamine receptor antagonists on ongoing maternal behavior in rats
Abstract
The effects of different peripheral doses of four dopamine (DA) receptor antagonists on general activity and maternal behavior were examined in lactating female rats. Administration of the classic D1-like and D2-like DA receptor blocker haloperidol (0.1 and 0.05 mg/kg) disrupted pup retrieval and nest-building behaviors and reduced motor activity. Pimozide (0.5 and 0.2 mg/kg), which has more affinity for DA D2-like receptors, mildly disrupted pup retrieval while showing no significant influence on open-field behaviors. The putative DA D(4) receptor blocker, clozapine (1.5 and 1.0 mg/kg) reduced motor activity significantly, while only 1.0 mg/kg dose significantly decreased percent of rats displaying nest building. The DA D1-like receptor blocker SKF-83566 (0.2 and 0.1 mg/kg) significantly reduced pup retrieval, nest building and motor activity. These results suggest a role for DA receptors in ongoing maternal behavior that correlates directly with general activity.
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D2R also seems to be necessary for maternal behavior, though the site of action has not been determined.
“D2R also seems to be necessary for maternal behavior, though the site of action has not been determined (Silva et al 2001).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Silva et al 2001
Cites
The Pharmacological Basis of Therapeutics
(1976) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/33.4.373a · Cited by 9,216 · see citing works
The Physiology of Reproduction
Legendre, M., & Jalabert, B. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-2-176_1 · Cited by 7,879 · see citing works
MAEDA, K., OHKURA, S., & Tsukamura, H. (2000) · Elsevier eBooks · doi:10.1016/b978-012426400-7/50048-0 · Cited by 2,135 · see citing works
Seeman, P. M. (1980) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06839-5 · Cited by 1,888 · see citing works
Genetics of Mouse Behavior: Interactions with Laboratory Environment
Crabbe, J. C., Wahlsten, D., & Dudek, B. C. (1999) · Science · doi:10.1126/science.284.5420.1670 · Cited by 1,666 · see citing works
Dopamine: A Prolactin-Inhibiting Hormone*
Ben‐Jonathan, N. (1985) · Endocrine Reviews · doi:10.1210/edrv-6-4-564 · Cited by 739 · see citing works
Oates, J. A., Wood, A. J. J., Baldessarini, R. J., & Frankenburg, F. R. (1991) · New England Journal of Medicine · doi:10.1056/nejm199103143241107 · Cited by 689 · see citing works
Drugs and the treatment of psychiatric disorders
Baldessarini, R. J. (1996) · Medical Entomology and Zoology · Cited by 686 · see citing works
The pharmacological basis of therapeutics
(1977) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(77)80405-7 · Cited by 427 · see citing works
Central prolactin infusions stimulate maternal behavior in steroid-treated, nulliparous female rats.
Bridges, R. S., Numan, M. J., Ronsheim, P. M., MANN, P., & Lupini, C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.20.8003 · Cited by 349 · see citing works
DETERMINANTS OF EMOTIONALITY IN RAT
Broadhurst, P. L. (1957) · British Journal of Psychology · doi:10.1111/j.2044-8295.1957.tb00594.x · Cited by 344 · see citing works
Obligatory D-1/D-2 receptor interaction in the generation of dopamine agonist related behaviors
Braun, A. R., & Chase, T. N. (1986) · European Journal of Pharmacology · doi:10.1016/0014-2999(86)90588-1 · Cited by 322 · see citing works
Novel dopamine receptors half a decade later
Sokoloff, P., & Schwartz, J.-C. (1995) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)89044-6 · Cited by 295 · see citing works
Prolactin Stimulation of Maternal Behavior in Female Rats
Bridges, R. S., DiBiase, R., Loundes, D. D., & DOHERTY, P. C. (1985) · Science · doi:10.1126/science.3969568 · Cited by 289 · see citing works
Genetic Variation in Susceptibility to Endocrine Disruption by Estrogen in Mice
Spearow, J. L., Doemeny, P., Sera, R., Leffler, R., & Barkley, M. S. (1999) · Science · doi:10.1126/science.285.5431.1259 · Cited by 254 · see citing works
Sex differences in striatal dopamine: in vivo microdialysis and behavioral studies
Castner, S. A., Li, X., & Becker, J. B. (1993) · Brain Research · doi:10.1016/0006-8993(93)91225-h · Cited by 253 · see citing works
Keer, S. E., & Stern, J. M. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00116-x · Cited by 250 · see citing works
Cholecystokinin-dopamine intearctions
Crawley, J. N. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90558-a · Cited by 249 · see citing works
Hansen, S., Bergvall, Å. H., & Nyiredi, S. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90523-v · Cited by 247 · see citing works
Forebrain expression of c-fos due to active maternal behaviour in lactating rats
Lonstein, J. S., Simmons, D. A., Swann, J. M., & Stern, J. M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00283-2 · Cited by 237 · see citing works
Sex differences in the rapid and acute effects of estrogen on striatal D2 dopamine receptor binding
Bazzett, T. J., & Becker, J. B. (1994) · Brain Research · doi:10.1016/0006-8993(94)91229-7 · Cited by 222 · see citing works
Hansen, S., Harthon, C., Waslin, E., Löfberg, L., & al, E. (1991) · Behavioral Neuroscience · doi:10.1037//0735-7044.105.4.588 · Cited by 211 · see citing works
The cerebral cortex: a case for a common site of action of antipsychotics
Lidow, M. S., Williams, G. V., & Goldman‐Rakic, P. S. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(98)01186-9 · Cited by 206 · see citing works
Fleming, A. S., Korsmit, M., & Deller, M. (1994) · Psychobiology · doi:10.3758/bf03327079 · Cited by 186 · see citing works
Hansen, S., Harthon, C., Wallin, E., et al. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.4.588 · Cited by 186 · see citing works
In rats, the behavioral profile of CCK-8 related peptides resembles that of antipsychotic agents
van Ree, J. M., Gaffori, O., & de Wied, D. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90031-6 · Cited by 184 · see citing works
ŒSTROGENS AND EXTRAPYRAMIDAL SYSTEM
Bédard, P. J., Langelier, P., & Villeneuve, A. (1977) · The Lancet · doi:10.1016/s0140-6736(77)90429-9 · Cited by 179 · see citing works
Prospects for pharmacotherapy of schizophrenia
Pickar, D. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90469-7 · Cited by 167 · see citing works
Hansen, S., Harthon, C., Wallin, E., Löfberg, L., & Svensson, K. A. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90399-m · Cited by 156 · see citing works
Hansen, S. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90034-5 · Cited by 132 · see citing works
Biochemical Basis of Parental Behavior in the Rat
Bridges, R. S. (1996) · Advances in the study of behavior · doi:10.1016/s0065-3454(08)60334-4 · Cited by 123 · see citing works
Haloperidol-induced disruption of retrieval behavior and reversal with apomorphine in lactating rats
Giordano, A. L., Johnson, A. E., & Rosenblatt, J. S. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90288-f · Cited by 123 · see citing works
Stern, J. M., & Taylor, L. A. (1991) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1991.tb00323.x · Cited by 99 · see citing works
McCullough, L. D., Cousins, M. S., & Salamone, J. D. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90547-7 · Cited by 95 · see citing works
Effects of single and long-term haloperidol administration on open field behavior of rats
Bernardi, M. M., Souza, H. D., & Neto, J. P. (1981) · Psychopharmacology · doi:10.1007/bf00429212 · Cited by 93 · see citing works
Self-citationMaternal motivation of lactating rats is disrupted by low dosages of haloperidol
Stern, J. M., & Keer, S. E. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00108-9 · Cited by 84 · see citing works
Cocaine alters the onset and maintenance of maternal behavior in lactating rats
Kinsley, C. H., Turco, D., Bauer, A., Beverly, M. F., Wellman, J., & Graham, A. L. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90288-7 · Cited by 78 · see citing works
Bernardi, M. M., & Neto, J. P. (1979) · Psychopharmacology · doi:10.1007/bf00492211 · Cited by 61 · see citing works
Self-citationFelício, L. F., Mann, P. E., & Bridges, R. S. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90422-x · Cited by 52 · see citing works
Cruz‐Casallas, P. E., Nasello, A. G., Hucke, E. E. T. S., & Felício, L. F. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00021-9 · Cited by 47 · see citing works
Frussa‐Filho, R., & Palermo‐Neto, J. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90663-2 · Cited by 46 · see citing works
Mann, P. E., Felício, L. F., & Bridges, R. S. (1995) · Hormones and Behavior · doi:10.1006/hbeh.1995.1027 · Cited by 42 · see citing works
Lévy, F., Meurisse, M., Ferreira, G., Thibault, J., & Tillet, Y. (1999) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(99)00005-8 · Cited by 42 · see citing works
Dopaminergic supersensitivity after long-term bromopride treatment
Felício, L. F., Nasello, A. G., & Palermo-Neto, J. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90077-1 · Cited by 38 · see citing works
Felício, L. F., & Bridges, R. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)90122-p · Cited by 38 · see citing works
Norman, P., Abram, T. S., Kluender, H. C. E., et al. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90456-0 · Cited by 33 · see citing works
Frussa‐Filho, R., & Palermo-Neto, J. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90024-i · Cited by 33 · see citing works
Miranda‐Paiva, C. M., & Felício, L. F. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00117-3 · Cited by 32 · see citing works
Tieppo, C. A., Ferreira, F. S., Sassatani, A. S., et al. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00782-7 · Cited by 16 · see citing works
Modulation of apomorphine-induced stereotyped behavior by cholecystokinin
Tieppo, C. A., Nasello, A. G., & Felício, L. F. (1997) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(97)00041-9 · Cited by 14 · see citing works
Effects of chronic domperidone treatment on rat conditioned avoidance behavior.
Vanzeler, M. L. A., Felício, L. F., & Nasello, A. G. (1990) · PubMed · Cited by 13 · see citing works
A Comparison of Bromopride and Domperidone Effects on Rat Conditioned Avoidance and Motor Activity
Nasello, A. G., Vanzeler, M. L. A., & Felício, L. F. (1991) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1991.tb01206.x · Cited by 10 · see citing works
Tieppo, C. A., Silva, A. M. P., Palermo‐Neto, J., et al. (1995) · PubMed · Cited by 10 · see citing works
Lithium effects on estrogen-induced dopaminergic supersensitivity in rats
Dorce, V. A. C., & Palermo‐Neto, J. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90032-s · Cited by 8 · see citing works
A system for halothane anesthesia in experimental surgery
Taylor, E. M. (1969) · Physiology & Behavior · doi:10.1016/0031-9384(69)90205-4 · Cited by 3 · see citing works
Acute bromopride treatments: effects on general activity and inhibitory avoidance in rats.
Nasello, A. G., & Felício, L. F. (1988) · PubMed · Cited by 3 · see citing works
Bailey (1999) · doi:10.1002/(sici)1098-2302(199909)35:2
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Johns, J. M., Joyner, P. W., McMurray, M. S., Elliott, D. L., Hofler, V. E., Middleton, C. L., Knupp, K., Greenhill, K. W., Lomas, L. M., & Walker, C. H. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.06.001 · Cited by 78 · see citing works
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- Authors
- Silva, M. R. P., Bernardi, M. M., & Felicio, L. F.
- Affiliations
- Universidade de São Paulo (BR)
- ORCID
- Bernardi, Maria M.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 68
- Issue
- 3
- Pages
- 461-468
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2005096597
- Cited by
- 82
- References
- 57
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 6
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine antagonists, maternal behavior, lactating rats, pup retrieval, nest building, haloperidol, pimozide, clozapine, D1-like receptors, D2-like receptors, dopamine D4 receptor, motor activity, open field behavior
- MeSH terms
- Adult, Blood Pressure, Cocaine, Epinephrine, Heart Rate, Humans, Injections, Intravenous, Male, Norepinephrine, Dopamine Uptake Inhibitors, Cocaine-Related Disorders
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