Interaction with pups enhances dopamine release in the ventral striatum of maternal rats: A microdialysis study
Abstract
A growing body of evidence suggests that an interference with dopamine (DA) transmission disrupts maternal behavior in the rat. The present brain microdialysis study was therefore conducted to investigate whether infants can modulate ventral striatal DA release in mother rats. There was a significant rise in the extracellular concentrations DA, 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in the ventral striatum when mothers were reunited with their litters following separation overnight. Nursing was the predominant behavior during this phase of the experiment. More active behaviors were elicited by soiling pups with flowerpot earth, and this was accompanied by further increases in DA, DOPAC, HVA, and 5-HIAA. It is suggested that pup-induced stimulation of ventral striatal DA release facilitates parental responses such as pup retrieval.
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Dopamine is released naturally in the nucleus accumbens of maternal rats during interactions with pups.
“DA is released naturally in the NAC of maternal rats during interactions with pups (Hansen et al 1993).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Hansen et al 1993
Applying dopaminergic antagonists or dopaminergic neurotoxins to the nucleus accumbens interrupts mother-pup interactions.
“whereas applying dopaminergic antagonists or dopaminergic neurotoxins to the region interrupts such interactions (Hansen et al., 1993, Hansen et al., 1991a, Keer and Stern, 1999, Numan et al., 2005).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Hansen et al., 1993
Dopamine is released within the nucleus accumbens when a mother rat grooms or licks her offspring or after being reunited with her offspring after forced separation.
“Dopamine is released within the nucleus accumbens when a mother rat grooms or licks her offspring or after being reunited with her offspring after forced separation (Champagne et al., 2004, Hansen et al., 1993).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Hansen et al., 1993
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- Authors
- Hansen, S., Bergvall, Å. H., & Nyiredi, S.
- Affiliations
- University of Gothenburg (SE)
- Corresponding author
- Hansen, S.
- ORCID
- Hansen, S.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1993-07
- Volume
- 45
- Issue
- 3
- Pages
- 673-676
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2083163486
- Cited by
- 247
- References
- 35
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 3 · 2022: 9 · 2021: 6 · 2020: 39 · 2019: 2 · 2018: 8 · 2017: 6 · 2016: 3 · 2015: 14 · 2014: 9 · 2013: 16 · 2012: 9
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- maternal behavior, dopamine release, ventral striatum, pup retrieval, maternal rats, DOPAC, homovanillic acid, 5-hydroxyindoleacetic acid, extracellular dopamine
- MeSH terms
- Animals, Corpus Striatum, Dialysis, Dopamine, Extracellular Space, Female, Homovanillic Acid, Hydroxyindoleacetic Acid, Maternal Behavior, 3,4-Dihydroxyphenylacetic Acid, Rats, Wistar, Rats
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