Cited by 64Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchAlcohol Consumption and Health Effects

Behavioral sensitization to ethanol in rats: evidence from the Sprague–Dawley strain

Hoshaw, Brian A, Lewis, Michael J·2001·Pharmacology Biochemistry and Behavior

Abstract

Although it has been shown with other drugs of abuse, behavioral sensitization has not been shown with ethanol in rats. One possible reason for the negative previous findings may be due to the doses of ethanol employed in the different phases of sensitization. In the current experiment, outbred Sprague-Dawley rats were divided into either high or low responders to novelty. They were pretreated for 15 days with intraperitoneal injections of either saline or 1.0 g/kg ethanol, and then given a challenge dose of 0.25 g/kg ethanol after a 3-week period. During the first 10 min after the challenge dose, rats high in response to novelty pretreated with ethanol displayed higher locomotor activity scores relative to the other three groups. These data demonstrated evidence for behavioral sensitization with ethanol in outbred rats.

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Crossref · 10.1016/s0091-3057(01)00489-0

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Authors
Hoshaw, B. A., & Lewis, M. J.
Affiliations
Temple University (US)
Corresponding author
Lewis, Michael J
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2001-04
Volume
68
Issue
4
Pages
685-690
ISSN
0091-3057 (ISSN-L)
OpenAlex
W1971284141
Cited by
64
References
36
Citations by year
2025: 1 · 2024: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2018: 4 · 2017: 3 · 2016: 4 · 2014: 3 · 2013: 1 · 2012: 2
FWCI
1.22
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Kenan Institute for Engineering, Technology and Science
  • National Institute on Drug Abuse (DA 07237)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
ethanol, behavioral sensitization, novelty response, locomotor activity, Sprague-Dawley rats, outbred rats, ethanol pretreatment
MeSH terms
Ethanol, Animals, Central Nervous System Depressants, Exploratory Behavior, Male, Motor Activity, Rats, Sprague-Dawley, Rats

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