Behavioral sensitization to ethanol in rats: evidence from the Sprague–Dawley strain
Abstract
Although it has been shown with other drugs of abuse, behavioral sensitization has not been shown with ethanol in rats. One possible reason for the negative previous findings may be due to the doses of ethanol employed in the different phases of sensitization. In the current experiment, outbred Sprague-Dawley rats were divided into either high or low responders to novelty. They were pretreated for 15 days with intraperitoneal injections of either saline or 1.0 g/kg ethanol, and then given a challenge dose of 0.25 g/kg ethanol after a 3-week period. During the first 10 min after the challenge dose, rats high in response to novelty pretreated with ethanol displayed higher locomotor activity scores relative to the other three groups. These data demonstrated evidence for behavioral sensitization with ethanol in outbred rats.
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In animals, repeated alcohol consumption leading to sensitization results in increased dopaminergic reactivity to alcohol and greater behavioral responsivity.
“In animals, recent findings have shown that repeated alcohol consumption leading to sensitization results in increased dopaminergic reactivity to alcohol (Didone, Masson, Quoilin, Seutin, & Quertemont, 2014), and greater behavioral responsivity (Hoshaw & Lewis, 2001).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Hoshaw & Lewis, 2001
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“In animals, recent findings have shown that repeated alcohol consumption leading to sensitization results in increased dopaminergic reactivity to alcohol (Didone, Masson, Quoilin, Seutin, & Quertemont, 2014), and greater behavioral responsivity (Hoshaw & Lewis, 2001).”
- Authors
- Hoshaw, B. A., & Lewis, M. J.
- Affiliations
- Temple University (US)
- Corresponding author
- Lewis, Michael J
- ORCID
- Lewis, Michael J
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 68
- Issue
- 4
- Pages
- 685-690
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W1971284141
- Cited by
- 64
- References
- 36
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2018: 4 · 2017: 3 · 2016: 4 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kenan Institute for Engineering, Technology and Science
- National Institute on Drug Abuse (DA 07237)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- ethanol, behavioral sensitization, novelty response, locomotor activity, Sprague-Dawley rats, outbred rats, ethanol pretreatment
- MeSH terms
- Ethanol, Animals, Central Nervous System Depressants, Exploratory Behavior, Male, Motor Activity, Rats, Sprague-Dawley, Rats
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