Effects of Acute and Repeated Ethanol Exposures on the Locomotor Activity of BXD Recombinant Inbred Mice
Abstract
Investigations of ethanol's (EtOH's) complex response profile, including locomotor and other effects, are likely to lead to a more in‐depth understanding of the constituents of alcohol addiction. Locomotor activity responses to acute and repeated EtOH (2 g/kg, ip) exposures were measured in BXD recombinant inbred (RI) mice and their C57BL/6J (B6) and DBA/2J (D2) progenitors. Both the acute response and the change in initial EtOH response with repeated treatments were strain‐dependent. The coefficient of genetic determination was 0.38–0.49 for initial locomotor response to EtOH, and 0.29 for change in response. Changes in response were largely attributable to sensitization of locomotor stimulation. Quantitative trait loci (QTL) analyses identified significant marker associations with basal activity, acute locomotor response, and change in response. Markers were for QTL on several chromosomes, and there was only one case of overlap in marker associations among phenotypes. Acute locomotor response and locomotor sensitization were negatively correlated with 3% EtOH preference drinking data collected in BXD Rl strains. Overall, these results demonstrate locomotor sensitization induced by EtOH, suggest independence of genetic determination of locomotor responses to acute and repeated EtOH exposure, and partially support a relationship between reduced sensitivity to the locomotor stimulant/sensitizing effects of EtOH and EtOH consumption.
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The genetic variation in acute responsiveness to drugs is different to that responsible for differences in sensitization.
“There is also evidence suggesting that the genetic variation in acute responsiveness to drugs is different to that responsible for differences in sensitization (Eisener-Dorman, Grabowski-Boase, & Tarantino, 2011; Phillips, Huson, & McKinnon, 1998; Phillips, Huson, Gwiazdon, Kasch, & Shen, 1995).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Phillips, Huson, Gwiazdon, Kasch, & Shen, 1995
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- Authors
- Phillips, T. J., Huson, M., Gwiazdon, C., Burkhart‐Kasch, S., & Shen, E. H.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Phillips, Tamara J.
- ORCID
- Phillips, Tamara J.
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 1995-04
- Volume
- 19
- Issue
- 2
- Pages
- 269-278
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- OpenAlex
- W2038799057
- Cited by
- 205
- References
- 51
- Citations by year
- 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 7 · 2012: 10
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01aa008621-05)
- National Institute on Alcohol Abuse and Alcoholism (AA-08621)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- ethanol, locomotor activity, locomotor sensitization, BXD recombinant inbred mice, genetic determination, quantitative trait loci, alcohol preference, alcoholism, strain differences, acute ethanol administration
- MeSH terms
- Ethanol, Alcoholism, Animals, Association Learning, Chromosome Mapping, Conditioning, Psychological, Dose-Response Relationship, Drug, Female, Genetic Markers, Injections, Intraperitoneal, Male, Mice, Inbred Strains, Motor Activity, Phenotype, Recombination, Genetic, Species Specificity, Stereotyped Behavior, X Chromosome, Mice
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