Cited by 396Neurotransmitter Receptor Influence on BehaviorTryptophan and brain disordersStress Responses and Cortisol

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The role of serotonin in human mood and social interaction

Young, Simon N., Leyton, Marco·2002·Pharmacology Biochemistry and Behavior

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Abstract

Alterations in brain tryptophan levels cause changes in brain serotonin synthesis, and this has been used to study the implication of altered serotonin levels in humans. In the acute tryptophan depletion (ATD) technique, subjects ingest a mixture of amino acids devoid of tryptophan. This results in a transient decline in tissue tryptophan and in brain serotonin. ATD can result in lower mood and increase in irritability or aggressive responding. The magnitude of the effect varies greatly depending on the susceptibility of the subject to lowered mood or aggressivity. Unlike ATD, tryptophan can be given chronically. Tryptophan is an antidepressant in mild to moderate depression and a small body of data suggests that it can also decrease aggression. Preliminary data indicate that tryptophan also increases dominant behavior during social interactions. Overall, studies manipulating tryptophan levels support the idea that low serotonin can predispose subjects to mood and impulse control disorders. Higher levels of serotonin may help to promote more constructive social interactions by decreasing aggression and increasing dominance.

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Sorted by citations

Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis
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“As with tryptophan loading, ATD had little or no effect on healthy subjects (Young and Leyton 2002; Booij et al. 2003; Fusar-Poli et al. 2006).”
Background
Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior
Patrick, R. P., & Ames, B. N. (2015) · The FASEB Journal · doi:10.1096/fj.14-268342 · Cited by 523
“There is an abundanceof evidence linking serotonin to social behavior (5, 6).”
Background
Interferon-alpha–induced changes in tryptophan metabolism
Capuron, L., Neurauter, G., Musselman, D. L., Lawson, D. H., Nemeroff, C. B., Fuchs, D., & Miller, A. H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00173-2 · Cited by 493
“These findings are in accordance with previous data supporting a role for serotonergic systems in mood regulation and aggressive/impulsive behavior (Oquendo and Mann 2000; Owens and Nemeroff 1994; Ravidran et al 1999; Young and Leyton 2002).”
Result

See all 396

Authors: Young, S. N., & Leyton, M.
Affiliations: McGill University (CA)
Corresponding author: Young, Simon N.
ORCID: Young, Simon N.
Leyton, Marco
Venue: Pharmacology Biochemistry and Behavior
Publisher: Elsevier BV
Published: 2002-04
Volume: 71
Issue: 4
Pages: 857-865
ISSN: 0091-3057 (ISSN-L)
DOI: 10.1016/s0091-3057(01)00670-0
OpenAlex: W1934200177
Cited by: 396
References: 127
Citations by year: 2026: 8 · 2025: 19 · 2024: 7 · 2023: 19 · 2022: 16 · 2021: 15 · 2020: 17 · 2019: 20 · 2018: 23 · 2017: 17 · 2016: 11 · 2015: 24 · 2014: 13 · 2013: 18 · 2012: 18
FWCI: 1.31
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology Biochemistry and Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: serotonin, tryptophan, acute tryptophan depletion, mood, aggression, irritability, depression, social interaction, impulse control disorders, serotonin synthesis
MeSH terms: Affect, Humans, Interpersonal Relations, Serotonin, Tryptophan, Antidepressive Agents, Second-Generation

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The role of serotonin in human mood and social interaction

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