The DOI matches its Crossref record; 125 of the 127 references it cites were found in a registry or an index.
The role of serotonin in human mood and social interaction
Abstract
Alterations in brain tryptophan levels cause changes in brain serotonin synthesis, and this has been used to study the implication of altered serotonin levels in humans. In the acute tryptophan depletion (ATD) technique, subjects ingest a mixture of amino acids devoid of tryptophan. This results in a transient decline in tissue tryptophan and in brain serotonin. ATD can result in lower mood and increase in irritability or aggressive responding. The magnitude of the effect varies greatly depending on the susceptibility of the subject to lowered mood or aggressivity. Unlike ATD, tryptophan can be given chronically. Tryptophan is an antidepressant in mild to moderate depression and a small body of data suggests that it can also decrease aggression. Preliminary data indicate that tryptophan also increases dominant behavior during social interactions. Overall, studies manipulating tryptophan levels support the idea that low serotonin can predispose subjects to mood and impulse control disorders. Higher levels of serotonin may help to promote more constructive social interactions by decreasing aggression and increasing dominance.
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“A substantial body of literature implicates 5-HT neurotransmission in social processing and behavior (e.g. Del-Ben et al. 2008; Young and Leyton, 2002).”
From Effects of MDMA on sociability and neural response to social threat and social reward (2009) · cites this paper as Young and Leyton, 2002
Citations
Cites
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Differences between males and females in rates of serotonin synthesis in human brain
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Tryptophan depletion causes a rapid lowering of mood in normal males
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Self-citation
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Sorted by citations
Jenkins, T., Nguyen, J., Polglaze, K., & Bertrand, P. (2016) · Nutrients · doi:10.3390/nu8010056 · Cited by 904
L -Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications
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“As with tryptophan loading, ATD had little or no effect on healthy subjects (Young and Leyton 2002; Booij et al. 2003; Fusar-Poli et al. 2006).”
BackgroundPatrick, R. P., & Ames, B. N. (2015) · The FASEB Journal · doi:10.1096/fj.14-268342 · Cited by 523
“There is an abundanceof evidence linking serotonin to social behavior (5, 6).”
BackgroundInterferon-alpha–induced changes in tryptophan metabolism
Capuron, L., Neurauter, G., Musselman, D. L., Lawson, D. H., Nemeroff, C. B., Fuchs, D., & Miller, A. H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00173-2 · Cited by 493
“These findings are in accordance with previous data supporting a role for serotonergic systems in mood regulation and aggressive/impulsive behavior (Oquendo and Mann 2000; Owens and Nemeroff 1994; Ravidran et al 1999; Young and Leyton 2002).”
Result
Metadata
- Authors
- Young, S. N., & Leyton, M.
- Affiliations
- McGill University (CA)
- Corresponding author
- Young, Simon N.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 71
- Issue
- 4
- Pages
- 857-865
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W1934200177
- Cited by
- 396
- References
- 127
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 7 · 2023: 19 · 2022: 16 · 2021: 15 · 2020: 17 · 2019: 20 · 2018: 23 · 2017: 17 · 2016: 11 · 2015: 24 · 2014: 13 · 2013: 18 · 2012: 18
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- serotonin, tryptophan, acute tryptophan depletion, mood, aggression, irritability, depression, social interaction, impulse control disorders, serotonin synthesis
- MeSH terms
- Affect, Humans, Interpersonal Relations, Serotonin, Tryptophan, Antidepressive Agents, Second-Generation
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