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Early deprivation and behavioral and physiological responses to social separation/novelty in the marmoset
Abstract
Long-term effects of adverse early environment on neurobehavioral development have been reported for rodents and primates. The present study used daily early deprivation (ED), a paradigm developed for rats, for the first time in a nonhuman primate, the common marmoset, and investigated its effects on the behavioral and physiological responses to social separation/novelty (SSN) challenge tests in juveniles. On postnatal days (PNDs) 2-28, infants (n=5 twin pairs) were removed from the parents and placed alone in an isolation chamber for 30-120 min (9 h/week). Parents and control subjects (n=5 twin pairs) were briefly restrained (CON). At Weeks 18-20, behavioral responses of ED and CON juveniles to six 60-min SSN tests in an isolated cage, comprising 45 min alone and 15 min reunion with the father, were measured. Baseline and post-test urine samples were collected for measurement of cortisol. ED subjects exhibited significantly lower basal SSN urinary cortisol than CON, whilst SSN response cortisol values were similar in ED and CON. When alone, ED subjects were significantly less mobile and emitted significantly less contact calls than CON. Following reunion, ED subjects were significantly less in contact with or being carried by the father than CON and demonstrated significantly more tail piloerection. Although they require validation by additional parameters (e.g. cardiovascular), these data strongly suggest that early-life stress alters endocrine and behavioral responsiveness…
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“This difference may reflect the effects of total social deprivation (in the case of early deprivation: Dettling et al., 2002) versus parental deprivation (in the case of peer-reared macaque monkeys: Higley et al., 1992; or marmoset offspring born to high IR mothers and fathers: current study).”
From Quality of maternal and paternal care predicts later stress reactivity in the cooperatively-breeding marmoset (Callithrix geoffroyi) (2013) · cites this paper as Dettling et al., 2002
In the citing paper
“infant marmosets (Callithrix jacchus) that were repeatedly separated from their caregivers (30 to 120 minutes) between 2 and 28 days of life showed lower baseline levels of urinary cortisol as juveniles than control animals (Dettling et al., 2002), but no differences were found in cortisol responses during social separation challenges.”
From Quality of maternal and paternal care predicts later stress reactivity in the cooperatively-breeding marmoset (Callithrix geoffroyi) (2013) · cites this paper as Dettling et al., 2002
In the citing paper
“empirical evidence suggests that marmoset HPA stress response styles are sensitive to variation in early environments.”
From Quality of maternal and paternal care predicts later stress reactivity in the cooperatively-breeding marmoset (Callithrix geoffroyi) (2013) · cites this paper as Dettling et al., 2002
In the citing paper
“In addition, and most similar to our findings, Dettling et al. (2002) also found no sex differences in HPA stress responses among young (18 weeks) marmosets, whether early-deprived or normally-reared.”
From Quality of maternal and paternal care predicts later stress reactivity in the cooperatively-breeding marmoset (Callithrix geoffroyi) (2013) · cites this paper as Dettling et al., 2002
In the citing paper
“Contrast this with the findings of Dettling et al., (2002), in which, compared to normally-reared controls, early deprived marmosets showed lower basal plasma cortisol levels, but similar cortisol responses to social stress.”
From Quality of maternal and paternal care predicts later stress reactivity in the cooperatively-breeding marmoset (Callithrix geoffroyi) (2013) · cites this paper as Dettling et al., 2002
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Metadata
- Authors
- Dettling, A. C., Feldon, J., & Pryce, C. R.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 73
- Issue
- 1
- Pages
- 259-269
- ISSN
- 0091-3057
- Cited by
- 95
- References
- 4
- Language
- en
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