Early Environmental Regulation of Forebrain Glucocorticoid Receptor Gene Expression: Implications for Adrenocortical Responses to Stress; pp. 49–60
Abstract
The adrenal glucocorticoids and catecholamines comprise a frontline of defense for mammalian species under conditions which threaten homeostasis (conditions commonly referred to as stress). Glucocorticoids represent the end product of the hypothalamic-pituitary-adrenal (HPA) axis and along with the catecholamines serve to mobilize the production and distribution of energy substrates during stress. The increased secretion of pituitary-adrenal hormones in response to stress is stimulated by the release of corticotropin-releasing hormone (CRH) and/or arginine vasopressin (AVP) from neurons in the nucleus paraventricularis. In this way, a neural signal associated with the stressor is transduced into a set of endocrine and sympathetic responses. The development of the HPA response to stressful stimuli is altered by early environmental events. Animals exposed to short periods of infantile stimulation or handling show decreased HPA responsivity to stress, whereas maternal separation, physical trauma and endotoxin administration enhance HPA responsivity to stress. In all cases, these effects persist throughout the life of the animal and are accompanied by increased hypothalamic levels of the mRNAs for CRH and often AVP. The inhibitory regulation of the synthesis for these ACTH releasing factors is achieved, in part, through a negative feedback loop whereby circulating glucocorticoids act at various neural sites to decrease CRH and AVP gene expression. Such inhibitory effects are initiated via an interaction between the adrenal steroid and an intracellular receptor (either the mineralocorticoid or glucocorticoid receptor). We have found that these early environmental manipulations regulate glucocorticoid receptor gene expression in the hippocampus and frontal cortex, regions that have been strongly implicated as sites for negative-feedback regulation of CRH and AVP synthesis. When the differences in glucocorticoid receptor density are transiently reversed, so too are those in HPA responses to stress. Taken together, our findings indicate that the early postnatal environment alters the differentiation of hippocampal neurons. This effect involves an altered rate of glucocorticoid receptor gene expression, resulting in changes in the sensitivity of the system to the inhibitory effects of glucocorticoids on the synthesis of CRH and AVP in hypothalamic neurons. Changes in CRH and AVP levels, in turn, determine the responsivity of the axis to subsequent stressors; increased releasing factor production is associated with increased HPA responses to stress. Thus, the early environment can contribute substantially to the development of stable individual differences in HPA responsivity to stressful stimuli. These data provide examples of early environmental programming of neural systems. One major objective of our research is to understand how such programming occurs within the brain.
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In rats, very mild stress early in life promotes resilience whereas more severe stressors exacerbate the stress response later in life.
“Similar effects have been shown to occur in rats, in which very mild stress early in life promotes resilience whereas more severe stressors exacerbate the stress response later in life125.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [125]
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- Authors
- Meaney, M. J., Diorio, J., Francis, D., Widdowson, J., LaPlante, P., Caldji, C., Sharma, S., Seckl, J. R., & Plotsky, P. M.
- Affiliations
- Douglas Mental Health University Institute (CA)
- University of Edinburgh (GB)
- Emory University (US)
- Venue
- Developmental Neuroscience
- Publisher
- S. Karger AG
- Published
- 2010-05-28
- Volume
- 18
- Issue
- 1-2
- Pages
- 49-60
- ISSN
- 0378-5866 (ISSN-L)
- 1421-9859
- OpenAlex
- W2055161357
- Cited by
- 878
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 32 · 2022: 8 · 2021: 19 · 2020: 15 · 2019: 12 · 2018: 16 · 2017: 19 · 2016: 18 · 2015: 40 · 2014: 28 · 2013: 32 · 2012: 49
- Type
- book review
- Language
- en
- Open access
- closed
- Locations
- Developmental Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- National Institute of Mental Health (MH-50113, R01MH050113)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- glucocorticoid receptor, gene expression, hypothalamic-pituitary-adrenal axis, stress response, corticotropin-releasing factor, vasopressin, negative feedback, hippocampus, frontal cortex, maternal separation, hypothalamic neurons, glucocorticoid receptor antagonist, developmental programming
- MeSH terms
- Adrenal Cortex, Animals, Environment, Gene Expression Regulation, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Receptors, Glucocorticoid, Stress, Physiological, Prosencephalon
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