Exposure to house dust mite allergens and the clinical activity of asthma

Custovic, Adnan; Taggart, Simon C.O.; Francis, Helen C.; Chapman, Martin D.; Woodcock, Ashley

doi:10.1016/s0091-6749(96)70227-0

Cited by 251Asthma and respiratory diseasesAllergic Rhinitis and SensitizationIndoor Air Quality and Microbial Exposure

Exposure to house dust mite allergens and the clinical activity of asthma

Open access

Custovic, Adnan, Taggart, Simon C.O., Francis, Helen C., Chapman, Martin D., Woodcock, Ashley·1996·Journal of Allergy and Clinical Immunology

DOI 10.1016/s0091-6749(96)70227-0

Open this paper in CoChat — free account Open PDF

Abstract

Background House dust mite allergens play an important role in inducing IgE-mediated sensitization and the development of bronchial hyperresponsiveness (BHR) and asthma. This study investigated the relationship between mite allergen exposure and the clinical activity and severity of asthma.Methods Nonsmoking adult patients with asthma (n = 53) were randomly recruited from the asthma registry of two large family practitioner surgeries. Each participant underwent skin testing with common inhalant allergens, a methacholine bronchoprovocation test, and pulmonary function testing on up to 3 separate occasions over a 4-week period. BHR was expressed both as PD20 and dose-response ratio (DRR), and the patients with patients with PD20 of less than 12.25 mumol methacholine were classified as methacholine reactors. Patients were also asked to record peak expiratory flow rate (PEFR) values at 2-hour intervals during waking hours for 1 month. Daily PEFR variability was calculated as amplitude percent mean. Dust samples were collected by vacuuming bedding, bedroom carpets and mattresses. In addition, in the homes of 32 subjects with positive skin test responses to mites, airborne samples were taken overnight for 8 hours with a personal sampler attached to each subject's pillow. Der p 1 and Der p 2 levels were determined by a two-site monoclonal antibody-based ELISA.Results No difference in mite exposure was found between subjects who were sensitive to mites and those who were not. However, mite-sensitive methacholine reactors were exposed to significantly higher concentrations of Der p 1 in beds than mite-sensitive methacholine nonreactors (13.2 micrograms/gm and 1.45 micrograms/gm, respectively; p < 0.02). Der p 1 and Der p 2 were undetectable in 30 of 32 airborne samples. In mite-sensitive patients both Der p 1 and Der p 2 in beds significantly correlated with BHR (PD20: r = -0.49, DRR, r = 0.49; PD20: r = -0.46, DRR: r = 0.43) and amplitude percent mean PEFR (r = 0.38, r = 0.41) for Der p 1 and Der p 2, respectively. There was a significant negative correlation between exposure to Der p 1 and percent predicted FEV1 (r = -0.43). The correlation between Der p 2 and percent predicted FEV1 just failed to reach a significant level but showed a clear trend ( r = -0.35, p = 0.068).Conclusions Clinical activity and severity of asthma (measured by the level of BHR, PEFR variability, and percent predicted FEV1) in mite-sensitive patients is related to exposure to mite allergens in the dust reservoir, with levels in bed being an important indicator that correlated with disease activity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/s0091-6749(96)70227-0

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Exposure to dust mite allergens in sensitized individuals is strongly associated with more severe asthma symptoms.
“Exposure to dust mite allergens in sensitized individuals has been strongly associated with more severe asthma symptoms (50).”
From Indoor Allergen Interventions in Homes and Schools for Managing Asthma (2025) · cites this paper as [50]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Exposure to House-Dust Mite Allergen (<i>Der p</i>I) and the Development of Asthma in Childhood: A Prospective Study
Sporik, R., Holgate, S. T., Platts-Mills, T. A. E., & Cogswell, J. J. (1990) · New England Journal of Medicine · doi:10.1056/nejm199008233230802 · Cited by 1,648 · see citing works
Allergen‐induced increase in non‐allergic bronchial reactivity
Cockcroft, D. W., Ruffin, R. E., Dolovich, J., & Hargreave, F. E. (1977) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1977.tb01481.x · Cited by 860 · see citing works
Changes in asthma prevalence: two surveys 15 years apart.
Burr, M. L., Butland, B. K., King, S., & Vaughan‐Williams, E. (1989) · Archives of Disease in Childhood · doi:10.1136/adc.64.10.1452 · Cited by 859 · see citing works
Rapid method for measurement of bronchial responsiveness.
Yan, K., Salome, C., & Woolcock, A. J. (1983) · Thorax · doi:10.1136/thx.38.10.760 · Cited by 758 · see citing works
REDUCTION OF BRONCHIAL HYPERREACTIVITY DURING PROLONGED ALLERGEN AVOIDANCE
Platts-Mills, T. E., Mitchell, E. B., Nock, P., Tovey, E. R., Moszoro, H., & Wilkins, S. R. (1982) · The Lancet · doi:10.1016/s0140-6736(82)90709-7 · Cited by 694 · see citing works
Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma
O'Hollaren, M. T., Yunginger, J. W., Offord, K. P., Somers, M. J., O'Connell, E. J., Ballard, D. J., & Sachs, M. I. (1991) · New England Journal of Medicine · doi:10.1056/nejm199102073240602 · Cited by 694 · see citing works
Dust mite allergens and asthma: Report of a second international workshop
Platts‐Mills, T. A. E. (1992) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(92)90228-t · Cited by 621 · see citing works
Analysis of Dose-Response Curves to Methacholine: An Approach Suitable for Population Studies
O’Connor, G. T., Sparrow, D., Taylor, D., Segal, M. R., Weiss, S. T., & Eleuteri, D. (1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.6.1412 · Cited by 463 · see citing works
The house-dust mite (Dermatophagoides pteronyssinus) and the allergens it produces. Identity with the house-dust allergen
Voorhorst, R., Spieksma, F. T. M., Varekamp, H., Leupen, M. J., & Lyklema, A. W. (1967) · Journal of Allergy · doi:10.1016/0021-8707(67)90045-7 · Cited by 423 · see citing works
Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma.
Juniper, E. F., Frith, P. A., & Hargreave, F. E. (1981) · Thorax · doi:10.1136/thx.36.8.575 · Cited by 399 · see citing works
Viruses as Precipitants of Asthmatic Attacks in Children
Minor, T. E. (1974) · JAMA · doi:10.1001/jama.1974.03230160020004 · Cited by 350 · see citing works
The control of allergens of dust mites and domestic pets: a position paper
Colloff, M., Ayres, J., Carswell, F., Howarth, P., Merrett, T. G., Mitchell, E., Walshaw, M., Warner, J. A., Warner, J. A., & Woodcock, A. (1992) · Clinical and Experimental Allergy · doi:10.1111/j.1365-2222.1992.tb01763.x · Cited by 334 · see citing works
Self-citation
The distribution of dust mite allergen in the houses of patients with asthma.
Tovey, E. R., Chapman, M. D., Wells, C. W., & Platts‐Mills, T. A. E. (1981) · PubMed · doi:10.1164/arrd.1981.124.5.630 · Cited by 307 · see citing works
Self-citation
House dust mite exposure as a cause of asthma
Sporik, R. B., Chapman, M. D., & Platts‐Mills, T. A. E. (1992) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1992.tb02062.x · Cited by 284 · see citing works
Self-citation
Association of Asthma with Serum IgE and Skin Test Reactivity to Allergens among Children Living at High Altitude. Tickling the Dragon's Breath
Sporik, R. B., Ingram, J. M., Price, W., SUSSMAN, J. S., Honsinger, R. W., & Platts‐Mills, T. A. E. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.151.5.7735590 · Cited by 249 · see citing works
Monoclonal immunoassay for major dust mite (Dermatophageides) allergens, Der p I and Der f I, and quantitative analysis of the allergen content of mite and house dust extracts
Chapman, M. D., Heymann, P. W., Wilkins, S. R., Brown, M. J., & Platts‐Mills, T. A. E. (1987) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(87)90128-x · Cited by 218 · see citing works
Self-citation
Development of IgE and IgG antibodies to food and inhalant allergens in children at risk of allergic disease.
Rowntree, S., Cogswell, J. J., Platts‐Mills, T. A. E., & Mitchell, E. B. (1985) · Archives of Disease in Childhood · doi:10.1136/adc.60.8.727 · Cited by 214 · see citing works
Antigenic Analysis of Household Dust Samples
Wood, R. A., Eggleston, P. A., Lind, P., Ingemann, L., Schwartz, B., Graveson, S., Terry, D., Wheeler, B., & Adkinson, N. F. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/137.2.358 · Cited by 187 · see citing works
The association between Dermatophagoides mites and the increasing prevalence of asthma in village communities within the Papua New Guinea highlands
Dowse, G. K., Turner, K. J., Stewart, G. A., Alpers, M. P., & Woolcock, A. J. (1985) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(85)90016-8 · Cited by 179 · see citing works
The Distribution of Peak Expiratory Flow Variability in a Population Sample
Higgins, B. G., Britton, J. R., Chinn, S., Jones, T., Jenkinson, D., Burney, P., & Tattersfield, A. E. (1989) · American Review of Respiratory Disease · doi:10.1164/ajrccm/140.5.1368 · Cited by 153 · see citing works
Clinical Significance of Skin Reactions to Mite Extracts in Children with Asthma
Smith, J. M., Disney, M. E., Williams, J. D., & Goels, Z. A. (1969) · BMJ · doi:10.1136/bmj.2.5659.723 · Cited by 147 · see citing works
Measurement of airborne mite antigen in homes of asthmatic children
Price, J. A., Pollock, I., Little, S. A., Longbottom, J. L., & Warner, J. O. (1990) · The Lancet · doi:10.1016/0140-6736(90)92268-m · Cited by 140 · see citing works
Indoor Allergens—Assessing and Controlling Adverse Health Effects
Pope, A. M. (1993) · JAMA · doi:10.1001/jama.1993.03500210021010 · Cited by 127 · see citing works
Pulmonary function and bronchial hyperreactivity in asthmatic children with house dust mite allergy during prolonged stay in the Italian Alps (Misurina, 1756 m).
Al, B., Niero, E., Antolini, I., Valletta, E. A., & Gaburro, D. (1985) · PubMed · Cited by 124 · see citing works
Seasonal variation in airway hyperresponsiveness and natural exposure to house dust mite allergens in patients with asthma
der Heide, S. V., de Monchy, J. G. R., de Vries, K., Bruggink, T. M., & Kauffman, H. F. (1994) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(94)90356-5 · Cited by 116 · see citing works
Asthma and Allergy to House-dust Mites in Populations Living in High Altitudes
Charpin, D., Kleisbauer, J. P., Lanteaume, A., Razzouk, H., VERVLOET, D., Toumi, M., Faraj, F., & Charpin, J. (1988) · CHEST Journal · doi:10.1378/chest.93.4.758 · Cited by 110 · see citing works
Exposure to house dust mite allergen of children admitted to hospital with asthma
Sporik, R., Platts-Mills, T. A., & Cogswell, J. (1993) · Clinical and Experimental Allergy · doi:10.1111/j.1365-2222.1993.tb00361.x · Cited by 94 · see citing works
Monoclonal antibodies to group II Dermatophagoides spp. allergens: Murine immune response, epitope analysis, and development of a two-site ELISA
Ovsyannikova, I. G., Vailes, L. D., Li, Y., Heymann, P. W., & Chapman, M. D. (1994) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(94)90211-9 · Cited by 83 · see citing works
Self-citation
Estimation and repeatability of the response to inhaled histamine in a community survey.
Chinn, S., Britton, J. R., Burney, P., Tattersfield, A. E., & Papacosta, O. (1987) · Thorax · doi:10.1136/thx.42.1.45 · Cited by 76 · see citing works
Medication requirements and house dust mite exposure in mite‐sensitive asthmatics
VERVLOET, D., Charpin, D., Haddi, E., N'Guyen, A., Birnbaum, J., Soler, M., & van der Brempt, X. (1991) · Allergy · doi:10.1111/j.1398-9995.1991.tb00620.x · Cited by 63 · see citing works
Lymphocyte subsets in bronchoalveolar lavage fluid obtained from stable asthmatics, and their correlations with bronchial responsiveness
Kelly, C. A., Stenton, S., Ward, C., BIRD, G., Hendrick, D. J., & Walters, E. H. (1989) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1989.tb02360.x · Cited by 60 · see citing works
Allergens and Asthma
Duff, A. L., & Platts‐Mills, T. A. E. (1992) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(16)38445-0 · Cited by 52 · see citing works
Asthma and the indoor environment: Assessment of the health implications of high indoor air humidity
Andersen, I., & Korsgaard, J. (1986) · Environment International · doi:10.1016/0160-4120(86)90022-x · Cited by 43 · see citing works
Dissimilarity in Methacholine and Adenosine 5′-Monophosphate Responsiveness 3 and 24 h after Allergen Challenge
Aalbers, R., Kauffman, H. F., Koëter, G. H., Postma, D. S., de Vries, K., & de Monchy, J. G. R. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/144.2.352 · Cited by 42 · see citing works
Absence of seasonal variation in concentrations of the house dust mite allergen Der p1 in south Manchester homes.
Kalra, S., Crank, P., Hepworth, J., Pickering, C. A., & Woodcock, A. A. (1992) · Thorax · doi:10.1136/thx.47.11.928 · Cited by 36 · see citing works
Self-citation
Mite asthma in childhood: A study of the relationship between exposure to house dust mites and disease activity
Kivity, S., Solomon, A., Soferman, R., Schwarz, Y., Mumcuoğlu, K. Y., & Topilsky, M. (1993) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(93)90341-c · Cited by 34 · see citing works
Allergens and Asthma
Platts‐Mills, T. A. E. (1990) · Allergy and Asthma Proceedings · doi:10.2500/108854190778879729 · Cited by 27 · see citing works
Current assessment practices for noncancer end points.
Shoaf, C. R. (1991) · Environmental Health Perspectives · doi:10.1289/ehp.9195111 · Cited by 13 · see citing works

Flagged first, then by citations

Research works printed but not linked: 5

[4]4. Sporik R, Holgate S, Platts Mills TAE, Cogswell J. Expo- sure to house dust mite allergen (Der p I) and the development of asthma in childhood. N Engl J Med 1990;323:502-7.
[5]5. Dowse GK, Turner KJ, Stewart GA, Alpers MP, Woolcock AJ. The association between Derrnatophagoides mites and the increasing prevalence of asthma. J Allergy Clin Immu- nol 1985;75:75-83.
[13]13. Yan K, Salome C, Woolcock AJ. Rapid method of mea- surement of bronchial hyperreactivity. Thorax 1983;38: 760-5.
[34]34. Price JA, Pollock J, Little SA, Longbottom JL, Warner JO. Measurement of airborne mite allergen in homes of asth- matic children. Lancet 1990;336:895-7.
[36]36. Marks G, Tovey E, Woolcock A. In subjects with asthma the concentration of Der p I in beds correlates with the severity of bronchial hyperresponsiveness and symptoms [Abstract]. Am Rev Respir Dis 1993;147:A458.

Sorted by citations

Indoor allergens and asthma:Report of the Third International Workshop
Platts‐Mills, T. A. E., VERVLOET, D., Thomas, W. R., Aalberse, R. C., & Chapman, M. D. (1997) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(97)70292-6 · Cited by 723 · see citing works
Self-citation
Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study
Lau, S., Illi, S., Sommerfeld, C., Niggemann, B., Bergmann, R. L., von Mutius, E., & Wahn, U. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02842-7 · Cited by 701 · see citing works
Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study
Green, R. M., Custovic, A., Sanderson, G., Hunter, J., Johnston, S. L., & Woodcock, A. (2002) · BMJ · doi:10.1136/bmj.324.7340.763 · Cited by 356 · see citing works
Self-citation
Effects of damp and mould in the home on respiratory health: a review of the literature
Peat, J. K., Dickerson, J., & Li, J. J. (1998) · Allergy · doi:10.1111/j.1398-9995.1998.tb03859.x · Cited by 346 · see citing works
Characterization and Immunobiology of House Dust Mite Allergens
Thomas, W. R., Smith, W.-A., Hales, B. J., Mills, K. L., & O’Brien, R. M. (2002) · International Archives of Allergy and Immunology · doi:10.1159/000065179 · Cited by 347 · see citing works
Dust Mite Proteolytic Allergens Induce Cytokine Release from Cultured Airway Epithelium
King, C., Brennan, S., Thompson, P. J., & Stewart, G. A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3645 · Cited by 323 · see citing works
Effect of Cat and Dog Ownership on Sensitization and Development of Asthma among Preteenage Children
Perzanowski, M. S., Rönmark, E., Platts‐Mills, T. A. E., & Lundbäck, B. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2201035 · Cited by 301 · see citing works
The role of dust mites in allergy
Miller, J. D. (2019) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-018-8693-0 · Cited by 250 · see citing works
Reversing the trend: Reducing the prevalence of asthma
Peat, J. K., & Li, J. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70517-8 · Cited by 196 · see citing works
House‐dust‐mite allergens
Thomas, W. R., & Smith, W.-A. (1998) · Allergy · doi:10.1111/j.1398-9995.1998.tb03987.x · Cited by 188 · see citing works
Allergen avoidance in the treatment of asthma and atopic disorders.
Custovic, A., Simpson, A., Chapman, M., & Woodcock, A. (1998) · Thorax · doi:10.1136/thx.53.1.63 · Cited by 189 · see citing works
Self-citation
Exposure and sensitization to indoor allergens: association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma
Langley, S. J., Goldthorpe, S., Craven, M., Morris, J., Woodcock, A., & Custovic, A. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1654 · Cited by 171 · see citing works
Self-citation
Allergens, Viruses, and Asthma Exacerbations
Murray, C. S., Simpson, A., & Čustović, A. (2004) · Proceedings of the American Thoracic Society · doi:10.1513/pats.2306027 · Cited by 160 · see citing works
Environmental assessment and exposure control of dust mites: a practice parameter
Portnoy, J. M., Miller, J. D., Williams, P. B., Chew, G. L., Miller, J. D., Zaitoun, F. H., Phipatanakul, W., Kennedy, K., Barnes, C. S., Grimes, C., et al. (2013) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2013.09.018 · Cited by 161 · see citing works
Association of asthma symptoms and severity with indoor bioaerosols
Ross, M. A., Curtis, L., Scheff, P. A., Hryhorczuk, D. O., Ramakrishnan, V., Wadden, R. A., & Persky, V. W. (2000) · Allergy · doi:10.1034/j.1398-9995.2000.00551.x · Cited by 154 · see citing works
Domestic allergens in public places III: house dust mite, cat, dog and cockroach allergens in British hospitals
Custovic, Fletcher, Pickering, Francis, Green, Smith, Chapman, & Woodcock (1998) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1998.00183.x · Cited by 146 · see citing works
Self-citation
The role of cats and dogs in asthma and allergy – a systematic review
Chen, C.-M., Tischer, C., Schnappinger, M., & Heinrich, J. (2010) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2009.12.003 · Cited by 133 · see citing works
Exercise induced bronchospasm in Ghana: differences in prevalence between urban and rural schoolchildren
Addo‐Yobo, E. O. D., Čustović, A., Taggart, S., Asafo-Agyei, A. P., & Woodcock, A. A. (1997) · Thorax · doi:10.1136/thx.52.2.161 · Cited by 139 · see citing works
Self-citation
International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem
Sánchez‐Borges, M., Fernández‐Caldas, E., Thomas, W. R., Chapman, M. D., Lee, B. W., Caraballo, L. R., Acevedo, N., Chew, F. T., Ansotegui, I. J., Behrooz, L., et al. (2017) · World Allergy Organization Journal · doi:10.1186/s40413-017-0145-4 · Cited by 136 · see citing works
Self-citation
The impact of poor housing and indoor air quality on respiratory health in children
Holden, K. A., Lee, A. R., Hawcutt, D. B., & Sinha, I. P. (2023) · Breathe · doi:10.1183/20734735.0058-2023 · Cited by 130 · see citing works
Benefits of high altitude allergen avoidance in atopic adolescents with moderate to severe asthma, over and above treatment with high dose inhaled steroids
Grootendorst, D. C., Dahlén, S., Bos, J. W. V. D., Duiverman, E. J., Veselic‐Charvat, M., Vrijlandt, E. J. L. E., O’Sullivan, S., Kumlin, M., Sterk, P. J., & Roldaan, A. C. (2001) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2001.01022.x · Cited by 123 · see citing works
Sensitivity and exposure to indoor allergens in adults with differing asthma severity
Tunnicliffe, W. S., Fletcher, T., Hammond, K., Roberts, K., Čustović, A., Simpson, A., Woodcock, A. A., & Ayres, J. G. (1999) · European Respiratory Journal · doi:10.1183/09031936.99.13365499 · Cited by 119 · see citing works
Self-citation
The Childhood Asthma Prevention Study (CAPS)
Mihrshahi, S., Peat, J. K., Webb, K., Tovey, E. R., Marks, G. B., Mellis, C. M., & Leeder, S. (2001) · Controlled Clinical Trials · doi:10.1016/s0197-2456(01)00112-x · Cited by 113 · see citing works
The effectiveness of measures to change the indoor environment in the treatment of allergic rhinitis and asthma: ARIA update (in collaboration with GA<sup>2</sup>LEN)
Custovic, A., & van Wijk, R. G. (2005) · Allergy · doi:10.1111/j.1398-9995.2005.00934.x · Cited by 113 · see citing works
Environmental Issues in Managing Asthma
Diette, G. B., McCormack, M. C., Hansel, N. N., Breysse, P. N., & Matsui, E. C. (2008) · Respiratory Care · doi:10.4187/respcare.08530602 · Cited by 111 · see citing works
Asthma control or severity: that is the question
Humbert, M. J. C., Holgate, S. T., Boulet, L., & Bousquet, J. (2007) · Allergy · doi:10.1111/j.1398-9995.2006.01308.x · Cited by 99 · see citing works
The non‐proteolytic house dust mite allergen Der p 2 induce NF‐κB and MAPK dependent activation of bronchial epithelial cells
Österlund, C., Grönlund, H., Polović, N., Sundström, S., Gafvelin, G., & Bucht, A. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03284.x · Cited by 95 · see citing works
Environmental allergens and asthma in urban elementary schools
Amr, S., Bollinger, M. E., Myers, M. F., Hamilton, R. G., Weiss, S. R., Rossman, M. J., Osborne, L., Timmins, S., KIMES, D. S., Levine, E. R., et al. (2003) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)63611-3 · Cited by 90 · see citing works
The importance of allergens in the development of asthma and the persistence of symptoms
Nelson, H. S. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.106154 · Cited by 90 · see citing works
House dust mite avoidance for children with asthma in homes of low-income families
Shapiro, G. G., Wighton, T. G., Chinn, T., Zuckrman, J., Eliassen, A. H., Picciano, J. F., & Platts‐Mills, T. A. E. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70181-8 · Cited by 88 · see citing works
House dust mite allergy: The importance of house dust mite allergens for diagnosis and immunotherapy
Huang, H., Sarzsinszky, E., & Vrtala, S. (2023) · Molecular Immunology · doi:10.1016/j.molimm.2023.04.008 · Cited by 89 · see citing works
Monitoring of occupational and environmental aeroallergens – EAACI Position Paper
Raulf, M., Buters, J., Chapman, M. D., Cecchi, L., Frederic de, B. L. A. Y., Doekes, G., Eduard, W., Heederik, D. J. J., Jeebhay, M. F., Kespohl, S., et al. (2014) · Allergy · doi:10.1111/all.12456 · Cited by 86 · see citing works
Self-citation
House Dust Mite Der p 1 Downregulates Defenses of the Lung by Inactivating Elastase Inhibitors
Brown, A., Farmer, K., MacDonald, L., Kalsheker, N. A., Pritchard, D., Haslett, C., Lamb, J. R., & Sallenave, J. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0060oc · Cited by 82 · see citing works
Importance of indoor allergens in the induction of allergy and elicitation of
Čustović, A., Simpson, A., & Woodcock, A. A. (1998) · Allergy · doi:10.1111/j.1398-9995.1998.tb05011.x · Cited by 82 · see citing works
Self-citation
To what extent is allergen exposure a risk factor for the development of allergic disease?
Custovic, A. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12450 · Cited by 79 · see citing works
Mouldy houses influence symptoms of asthma among atopic individuals
Dharmage, S. C., Bailey, M., Raven, J. M., Abeyawickrama, K., Cao, D., Guest, D. I., Rolland, J. M., Forbes, A. B., Thien, F. C. K., Abramson, M. J., et al. (2002) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2002.01371.x · Cited by 79 · see citing works
Respiratory symptoms in relation to indoor exposure to mite and cat allergens and endotoxins
Gehring, U., Heinrich, J., Jacob, B., Richter, K. R., Fahlbusch, B., Schlenvoigt, G., Bischof, W., & Wichmann, H. ‐. (2001) · European Respiratory Journal · doi:10.1183/09031936.01.00096801 · Cited by 79 · see citing works
Changes in indoor allergen and fungal levels predict changes in asthma activity among young adults
Matheson, M. C., Abramson, M. J., Dharmage, S. C., Forbes, A. B., Raven, J. M., Thien, F. C. K., & Walters, E. H. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02272.x · Cited by 77 · see citing works
Chemical Respiratory Allergy: Opportunities for Hazard Identification and Characterisation
Kimber, I., Agius, R. M., Basketter, D. A., Corsini, E., Cullinan, P., Dearman, R. J., Giménez‐Arnau, E., Greenwell, L. L., Härtung, T., Kuper, C. F., et al. (2007) · Alternatives to Laboratory Animals · doi:10.1177/026119290703500212 · Cited by 74 · see citing works
Current Indoor Allergen Levels of Fungi and Cats, But Not House Dust Mites, Influence Allergy and Asthma in Adults with High Dust Mite Exposure
Dharmage, S. C., Bailey, M., Raven, J. M., Mitakakis, T. Z., CHENG, A., Guest, D. I., Rolland, J. M., Forbes, A. B., Thien, F. C. K., Abramson, M. J., et al. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.1.9911066 · Cited by 77 · see citing works
Controlling indoor allergens.
Custovic, A., Murray, C., Gore, R., & Woodcock, A. (2002) · Annals of Allergy, Asthma & Immunology · doi:10.1016/s1081-1206(10)62378-2 · Cited by 63 · see citing works
Self-citation
Relationship between exposure to domestic allergens and bronchial hyperresponsiveness in non-sensitised, atopic asthmatic subjects
Langley, S. J. (2005) · Thorax · doi:10.1136/thx.2004.027839 · Cited by 74 · see citing works
Utility of Peak Expiratory Flow Monitoring
Jain, P., Kavuru, M. S., Emerman, C. L., & Ahmad, M. (1998) · CHEST Journal · doi:10.1378/chest.114.3.861 · Cited by 72 · see citing works
Stringent environmental control in pregnancy and early life: the long‐term effects on mite, cat and dog allergen
Simpson, A., Simpson, B., Čustović, A., Craven, M., & Woodcock, A. A. (2003) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2745.2003.01679.x · Cited by 71 · see citing works
Self-citation
Allergen avoidance is associated with a fall in exhaled nitric oxide in asthmatic children☆☆☆★
PIACENTINI, G. L., Bodini, A., Costella, S., Vicentini, L. M., Peroni, D. G., Zanolla, L., & Boner, A. L. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70031-x · Cited by 71 · see citing works
HLA and asthma phenotypes/endotypes: A review
Kontakioti, E., Domvri, K., Papakosta, D., & Daniilidis, M. (2014) · Human Immunology · doi:10.1016/j.humimm.2014.06.022 · Cited by 70 · see citing works
Respiratory immunotoxicity: An in vitro assessment
Roggen, E., Soni, N. K., & Verheyen, G. R. (2006) · Toxicology in Vitro · doi:10.1016/j.tiv.2006.03.009 · Cited by 70 · see citing works
Effects of Physical Interventions on House Dust Mite Allergen Levels in Carpet, Bed, and Upholstery Dust in Low-Income, Urban Homes
Vojta, P. J., Randels, S. P., Stout, J., Muilenberg, M. L., Burge, H. A., Lynn, H., Mitchell, H., O’Connor, G. T., & Zeldin, D. C. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109815 · Cited by 68 · see citing works
Prevention of asthma
Peat, J. K. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09071545 · Cited by 67 · see citing works
Clinical evaluation of the effect of anti-allergic mattress covers in patients with moderate to severe asthma and house dust mite allergy: a randomised double blind placebo controlled study
Rijssenbeek‐Nouwens, L. H. (2002) · Thorax · doi:10.1136/thorax.57.9.784 · Cited by 65 · see citing works
Allergen‐avoidance measures in homes of house‐dust‐mite‐allergic asthmatic patients: effects of acaricides and mattress encasings
der Heide, S. V., Kauffman, H. F., Dubois, A. E. J., & de Monchy, J. G. R. (1997) · Allergy · doi:10.1111/j.1398-9995.1997.tb01252.x · Cited by 65 · see citing works
The role of inhalant allergens in allergic airways disease.
Čustović, A., & Simpson, A. (2012) · PubMed · Cited by 61 · see citing works
Determinants of endotoxin levels in carpets in New Zealand homes
Wickens, K. L., Douwes, J. E., Siebers, R. W. L., Fitzharris, P., Wouters, I. M., Doekes, G., Mason, K., Hearfield, M., Cunningham, M. J., & Crane, J. (2003) · Indoor Air · doi:10.1034/j.1600-0668.2003.00187.x · Cited by 61 · see citing works
Individual allergens as risk factors for asthma and bronchial hyperresponsiveness in Chinese children
Wong, G., Li, S. T., Hui, D. S. C., Fok, T. F., Zhong, N., Chen, Y. Z., & Lai, C.-Y. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.002319.02 · Cited by 60 · see citing works
Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations
Hunninghake, G. M., Soto-Quirós, M. E., Lasky-Su, J. A., Ávila, L., Ly, N. P., Liang, C., Klanderman, B. J., Raby, B. A., Gold, D. R., Weiss, S. T., et al. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.03.015 · Cited by 59 · see citing works
House dust mite allergen (Der p 1) accumulation on new synthetic and feather pillows
Rains, Siebers, R. W. L., Crane, & Fitzharris (1999) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1999.00470.x · Cited by 59 · see citing works
Focus on Cat Allergen (Fel d 1): Immunological and Aerodynamic Characteristics, Modality of Airway Sensitization and Avoidance Strategies
Liccardi, G., D'Amato, G., Russo, M., Canonica, G., D'Amato, L., Martino, M. D., & Passalacqua, G. (2003) · International Archives of Allergy and Immunology · doi:10.1159/000073259 · Cited by 58 · see citing works
Effects of house dust mite avoidance measures on Der p 1 concentrations and clinical condition of mild adult house dust mite‐allergic asthmatic patients, using no inhaled steroids
Cloosterman, Schermer, T. R., Bijl‐Hofland, van der Heide, Brunekreef, B., Elshout, V. D., Herwaarden, V., & van Schayck (1999) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1999.00627.x · Cited by 57 · see citing works
Early sensitisation and development of allergic airway disease – risk factors and predictors
Halken, S. (2003) · Paediatric Respiratory Reviews · doi:10.1016/s1526-0542(03)00026-5 · Cited by 56 · see citing works
A randomized controlled trial of mite allergen‐impermeable bed covers in adult mite‐sensitized asthmatics
Luczynska, C. M., Tredwell, E., Smeeton, N., & Burney, P. (2003) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2003.01729.x · Cited by 56 · see citing works
High‐altitude treatment: a therapeutic option for patients with severe, refractory asthma?
Rijssenbeek‐Nouwens, L. H., & Bel, E. H. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03733.x · Cited by 53 · see citing works
Asthma Severity According to Global Initiative for Asthma and Its Determinants: An International Study
Cazzoletti, L., Marcon, A., Corsico, A. G., Janson, C., Jarvis, D., Pin, I., Accordini, S., Bugiani, M., Cerveri, I., Gíslason, D., et al. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000232572 · Cited by 50 · see citing works
Changing Prevalence of Asthma and Allergic Diseases among Kuwaiti Children
Owayed, A., Behbehani, N., & Al-Momen, J. (2008) · Medical Principles and Practice · doi:10.1159/000129607 · Cited by 50 · see citing works
Update on House Dust Mite Allergen Avoidance Measures for Asthma
Zuiani, C., & Čustović, A. (2020) · Current Allergy and Asthma Reports · doi:10.1007/s11882-020-00948-y · Cited by 48 · see citing works
Can asthma be prevented? Evidence from epidemiological studies of children in Australia and New Zealand in the last decade
Peat (1998) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1998.00203.x · Cited by 47 · see citing works
A rapid test for detection of mite allergens in homes
Tsay, A., Williams, L. H., Mitchell, E. B., & Chapman, M. D. (2002) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2002.01533.x · Cited by 46 · see citing works
Self-citation
Evidence driven indoor air quality improvement: An innovative and interdisciplinary approach to improving indoor air quality
Lovrić, M., Gajski, G., Fernández-Agüera, J., Pöhlker, M. L., Gursch, H., Borg, A., Switters, J., & Mureddu, F. (2024) · BioFactors · doi:10.1002/biof.2126 · Cited by 44 · see citing works
Allergen avoidance in asthma: What do we do now?
O’Connor, G. T. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.02.013 · Cited by 44 · see citing works
A Cohort Study of Indoor Nitrogen Dioxide and House Dust Mite Exposure in Asthmatic Children
Nitschke, M., Pilotto, L., Attewell, R. G., Smith, B. J., Pisaniello, D., Martin, J. M., Ruffin, R. E., & Hiller, J. E. (2006) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000215802.43229.62 · Cited by 44 · see citing works
IgE‐Mediated Asthma and Rhinitis I: A Role of Allergen Exposure?
Nielsen, G. D., Hansen, J. S., Lund, R. M., Bergqvist, M., Larsen, S. T., Clausen, S. K., Thygesen, P., & Poulsen, O. M. (2002) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2002.900502.x · Cited by 45 · see citing works
Allergen-Specific CD4+ T Cells in Human Asthma
Ling, M. F., & Luster, A. D. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201507-431mg · Cited by 42 · see citing works
Indoor environment, atopy and the risk of asthma in children in New Zealand
Wickens, K. L., Pearce, N. E., Siebers, R. W. L., Ellis, I., Patchett, K., Sawyer, G., Stone, L., Tohill, S., Kennedy, J., Slater, T., et al. (1999) · Pediatric Allergy and Immunology · doi:10.1034/j.1399-3038.1999.00033.x · Cited by 42 · see citing works
Exposure to a high concentration of mite allergen in early infancy is a risk factor for developing atopic dermatitis: A 3‐year follow‐up study
Huang, J., Chen, C., Kuo, M., & Hsieh, K. (2001) · Pediatric Allergy and Immunology · doi:10.1034/j.1399-3038.2001.012001011.x · Cited by 41 · see citing works
Metabolomics Reveals Inflammatory-Linked Pulmonary Metabolic Alterations in a Murine Model of House Dust Mite-Induced Allergic Asthma
Ho, W. E., Xu, Y., Chang, C. K., Peh, H. Y., Tannenbaum, S. R., Wong, W. S. F., & Ong, C. N. (2014) · Journal of Proteome Research · doi:10.1021/pr5003615 · Cited by 38 · see citing works
House dust mite allergen avoidance and self-management in allergic patients with asthma: randomised controlled trial.
de Vries, M. P., van den Bemt, L., Aretz, K., Thoonen, B. P. A., Muris, J. W. M., Kester, A. D. M., Cloosterman, S. G. M., & van Schayck, O. C. P. (2007) · PubMed Central · Cited by 38 · see citing works
An exploration of the skills needed for inhalation therapy in schoolchildren with asthma in Taiwan
Chen, S., Yin, T. J. C., & Huang, J. (2002) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61960-6 · Cited by 38 · see citing works
Risk levels for mite allergens. Are they meaningful?
Čustović, A., & Chapman, M. D. (1998) · Allergy · doi:10.1111/j.1398-9995.1998.tb05002.x · Cited by 38 · see citing works
Self-citation
Antiallergic Cromones Inhibit Neutrophil Recruitment Onto Vascular Endothelium via Annexin-A1 Mobilization
Yazid, S., Leoni, G., Getting, S. J., Cooper, D., Solito, E., Perretti, M., & Flower, R. J. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.209536 · Cited by 37 · see citing works
Home allergen monitoring and control – improving clinical practice and patient benefits
Chapman, M. D., Tsay, A., & Vailes, L. D. (2001) · Allergy · doi:10.1034/j.1398-9995.2001.00049.x · Cited by 37 · see citing works
Self-citation
House dust mite exposure as a risk factor for asthma: benefits of avoidance
Marks, G. B. (1998) · Allergy · doi:10.1111/j.1398-9995.1998.tb05010.x · Cited by 35 · see citing works
Mimotopes identify conformational B-cell epitopes on the two major house dust mite allergens Der p 1 and Der p 2
Szalai, K., Fuhrmann, J., Pavkov‐Keller, T., Scheidl, M., Wallmann, J., Brämswig, K. H., Vrtala, S., Scheiner, O., Keller, W., Saint‐Remy, J., et al. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.09.012 · Cited by 33 · see citing works
Environmental Factors and Childhood Asthma
Phipatanakul, W. (2006) · Pediatric Annals · doi:10.3928/0090-4481-20060901-08 · Cited by 33 · see citing works
Intranasal air sampling in homes: Relationships among reservoir allergen concentrations and asthma severity
Gore, R. B., Curbishley, L., Truman, N. J., Hadley, E., Woodcock, A. A., Langley, S. J., & Čustović, A. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.12.1351 · Cited by 33 · see citing works
Self-citation
Allergen avoidance in the secondary and tertiary prevention of allergic diseases: does it work?
Marinho, S., Simpson, A., & Čustović, A. (2006) · Primary Care Respiratory Journal · doi:10.1016/j.pcrj.2006.02.005 · Cited by 32 · see citing works
Mite and mite allergen removal during machine washing of laundry
Arlian, L. G., Vyszenski-Moher, D. L., & Morgan, M. S. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1547 · Cited by 32 · see citing works
Role of the indoor environment in determining the severity of asthma
Woodcock, A. A., & Čustović, A. (1998) · Thorax · doi:10.1136/thx.53.2008.s47 · Cited by 32 · see citing works
Self-citation
The effect of anti‐allergic mattress encasings on house dust mite‐induced early‐ and late‐airway reactions in asthmatic patients. A double‐blind, placebo‐controlled study
Rijssenbeek‐Nouwens, L. H., Oosting, A. J., de Monchy, J. G. R., Bregman, I., Postma, D. S., & de Bruin-Weller, M. S. (2002) · Clinical & Experimental Allergy · doi:10.1046/j.0022-0477.2001.01256.x · Cited by 32 · see citing works
A Model for the Determination of Pollen Count Using Google Search Queries for Patients Suffering from Allergic Rhinitis
König, V., & Mösges, R. (2014) · Journal of Allergy · doi:10.1155/2014/381983 · Cited by 31 · see citing works
Comparison of two dust collection methods for reservoir indoor allergens and endotoxin on carpets and mattresses
Wickens, K. L., Lane, J. M., Siebers, R. W. L., Ingham, T. R., & Crane, J. (2004) · Indoor Air · doi:10.1111/j.1600-0668.2004.00253.x · Cited by 31 · see citing works
Domestic control of house dust mite allergen in children’s beds
Vanlaar, C. H., Peat, J. K., Marks, G. B., Rimmer, J., & Tovey, E. R. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.106213 · Cited by 31 · see citing works
House dust mite allergen levels in German day-care centers
Engelhart, S., Bieber, T. R. M., & Exner, M. (2002) · International Journal of Hygiene and Environmental Health · doi:10.1078/1438-4639-00192 · Cited by 30 · see citing works
Environmental allergen reduction in asthma management: an overview
Pham, D. L., Le, K., Truong, D. D. K., Le, H. T. T., & Trinh, H. K. T. (2023) · Frontiers in Allergy · doi:10.3389/falgy.2023.1229238 · Cited by 29 · see citing works
Genome-wide interaction study of dust mite allergen on lung function in children with asthma
Forno, E., Sordillo, J. E., Brehm, J. M., Chen, W., Benos, T., Yan, Q., Ávila, L., Soto-Quirós, M., Cloutier, M. M., Colón‐Semidey, A., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.12.967 · Cited by 29 · see citing works
Mite allergen exposure, sensitisation and clinical symptoms in Valdivia, Chile.
Calvo, M. A., Fernández-Caldas, E., Pérez-Arellano, J.-L., Marín, F., Carnés, J., & Hormaechea, A. (2005) · PubMed · Cited by 29 · see citing works
Indoor allergen exposure in the development of allergy and asthma
Arshad, S. H. (2003) · Current Allergy and Asthma Reports · doi:10.1007/s11882-003-0023-8 · Cited by 29 · see citing works
Pets and cockroaches: two increasing causes of respiratory allergy in indoor environments. Characteristics of airways sensitization and prevention strategies
Liccardi, G., Cazzola, M., D’Amato, M., & D’Amato, G. (2000) · Respiratory Medicine · doi:10.1053/rmed.2000.0922 · Cited by 29 · see citing works
Determinants of airway hyperresponsiveness in mild asthma
Currie, G. P., Jackson, C. M., Lee, D. K. C., & Lipworth, B. J. (2003) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61851-0 · Cited by 28 · see citing works
Association Between Nonspecific Airway Hyperresponsiveness and Arg16Gly β 2 -Adrenergic Receptor Gene Polymorphism in Asymptomatic Healthy Japanese Subjects
Fukui, Y., Hizawa, N., Takahashi, D., MAEDA, Y. Y., Jinushi, E., Konno, S., & Nishimura, M. (2006) · CHEST Journal · doi:10.1378/chest.130.2.449 · Cited by 28 · see citing works
Biologic pollution in infant bedding in New Zealand: High allergen exposure during a vulnerable period
Sawyer, G., Kemp, T., Shaw, R., Patchett, K., Siebers, R. W. L., Lewis, S., Beasley, R. W., Crane, J., & Fitzharris, P. (1998) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(98)70016-8 · Cited by 28 · see citing works
Daily Vacuuming of Mattresses Significantly Reduces House Dust Mite Allergens, Bacterial Endotoxin, and Fungal β-Glucan
Wu, F. F.-S., Wu, M.-W., Pierse, N., Crane, J., & Siebers, R. W. L. (2012) · Journal of Asthma · doi:10.3109/02770903.2011.654023 · Cited by 27 · see citing works

Effect of current exposure to Der p 1 on asthma symptoms, airway inflammation, and bronchial hyperresponsiveness in mite‐allergic asthmatics
Alvarez, M. J., Olaguibel, J. M., Acero, S., García, B. E., Tabar, A. I., & Urbiola, E. (2000) · Allergy · doi:10.1034/j.1398-9995.2000.00398.x · Cited by 15 · see citing works
Low domestic exposure to house dust mite allergens (Der p 1) is associated with a reduced non‐specific bronchial hyper‐responsiveness in mite‐sensitized asthmatic subjects under optimal drug treatment
Maestrelli, P., Zanolla, L., Puccinelli, P., Pozzan, M., & Fabbri, L. M. (2001) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2001.01020.x · Cited by 20 · see citing works
Mite allergen content in mattress dust of Dermatophagoides‐allergic asthmatics/rhinitics and matched controls
Pauli, G., Quoix, É., Hédelin, G., Bessot, J. C., Ott, M., & Dietemann, A. (1993) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1993.tb00901.x · Cited by 33 · see citing works
Mite asthma in childhood: A study of the relationship between exposure to house dust mites and disease activity
Kivity, S., Solomon, A., Soferman, R., Schwarz, Y., Mumcuoğlu, K. Y., & Topilsky, M. (1993) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(93)90341-c · Cited by 34 · see citing works
The effect of changes in house dust mite allergen exposure on the severity of asthma
Marks, G. B., Tovey, E. R., GREEN, W., Shearer, M., Salome, C. M., & Woolcock, A. J. (1995) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1995.tb01015.x · Cited by 59 · see citing works

Authors: Custovic, A., Taggart, S. C. O., Francis, H. C., Chapman, M. D., & Woodcock, A.
Affiliations: Wythenshawe Hospital (GB)
ORCID: Chapman, Martin D.
Woodcock, Ashley
Venue: Journal of Allergy and Clinical Immunology
Publisher: Elsevier BV
Published: 1996-07
Volume: 98
Issue: 1
Pages: 64-72
ISSN: 0091-6749 (ISSN-L)
DOI: 10.1016/s0091-6749(96)70227-0
OpenAlex: W2163112340
Cited by: 251
References: 38
Citations by year: 2025: 3 · 2024: 4 · 2023: 6 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 4 · 2014: 11 · 2013: 4 · 2012: 7
FWCI: 11.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Allergy and Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Funders: National Institutes of Health (5r01ai032557-08)
National Institute of Allergy and Infectious Diseases (AI34607, AI 32557)
Topics: Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Keywords: house dust mite allergens, asthma, airway hyperresponsiveness, Der p 1, Der p 2, indoor allergen exposure, peak expiratory flow variability, asthma severity, IgE sensitization, house dust mite allergy, FEV1 decline
MeSH terms: Adult, Allergens, Animals, Asthma, Dust, Female, Glycoproteins, Humans, Male, Mites, Air Pollution, Indoor, Antigens, Dermatophagoides

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Exposure to house dust mite allergens and the clinical activity of asthma

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks