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Initiation of Protein Synthesis from the A Site of the Ribosome
Open accessAbstract
Positioning of the translation initiation complex on mRNAs requires interaction between the anticodon of initiator Met-tRNA, associated with eIF2-GTP and 40S ribosomal subunit, and the cognate start codon of the mRNA. We show that an internal ribosome entry site located in the genome of cricket paralysis virus can form 80S ribosomes without initiator Met-tRNA, eIF2, or GTP hydrolysis, with a CCU triplet in the ribosomal P site and a GCU triplet in the A site. P-site mutagenesis revealed that the P site was not decoded, and protein sequence analysis showed that translation initiates at the triplet in the A site. Translational initiation from the A site of the ribosome suggests that the repertoire of translated open reading frames in eukaryotic mRNAs may be greater than anticipated.
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Gray, N. K., & Hentze, M. W. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06699.x · Cited by 276
Cited by
The mechanism of eukaryotic translation initiation and principles of its regulation
Jackson, R. J., Hellen, C. U. T., & Pestova, T. V. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2838 · Cited by 2,759
Self-citationLu, P. D., Harding, H. P., & Ron, D. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408003 · Cited by 1,006
Internal ribosome entry sites in eukaryotic mRNA molecules
Hellen, C. U. T., & Sarnow, P. (2001) · Genes & Development · doi:10.1101/gad.891101 · Cited by 986
Self-citationImpact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action
García, M. A., Gil, J., Ventoso, I., Guerra, S., Domingo, E., Rivas, C., & Esteban, M. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00027-06 · Cited by 818
Gene-Specific Regulation by General Translation Factors
Dever, T. E. (2002) · Cell · doi:10.1016/s0092-8674(02)00642-6 · Cited by 719
Metadata
- Authors
- Wilson, J. E., Pestova, T. V., Hellen, C. U. T., & Sarnow, P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 102
- Issue
- 4
- Pages
- 511-520
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2109009498
- Cited by
- 430
- References
- 1
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wilson, J. E., Pestova, T. V., Hellen, C. U. T., & Sarnow, P. (2000). Initiation of Protein Synthesis from the A Site of the Ribosome. Cell. https://doi.org/10.1016/s0092-8674(00)00055-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
