Signaling to Chromatin through Histone Modifications

Crystal structure of the nucleosome core particle at 2.8 Å resolution

Luger, K., Mäder, A. W., Richmond, R. K., Sargent, D. F., & Richmond, T. J. (1997) · Nature · doi:10.1038/38444 · Cited by 9,466

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438

Regulation of chromatin structure by site-specific histone H3 methyltransferases

Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z.-W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., et al. (2000) · Nature · doi:10.1038/35020506 · Cited by 2,845

Chromatin Structure: A Repeating Unit of Histones and DNA

Kornberg, R. D. (1974) · Science · doi:10.1126/science.184.4139.868 · Cited by 2,662

Signaling—2000 and Beyond

Hunter, T. (2000) · Cell · doi:10.1016/s0092-8674(00)81688-8 · Cited by 2,586

IAP family proteins---suppressors of apoptosisPreprint

Deveraux, Q. L., & Reed, J. C. (1999) · Genes & Development · doi:10.1101/gad.13.3.239 · Cited by 2,535

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.905 · Cited by 2,422

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals

Shaywitz, A. J., & Greenberg, M. E. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.821 · Cited by 2,133

Phosphorylated CREB binds specifically to the nuclear protein CBP

Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R., & Goodman, R. H. (1993) · Nature · doi:10.1038/365855a0 · Cited by 2,052

Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation

Hendzel, M. J., Wei, Y., Mancini, M. A., Hooser, A. A. V., Ranalli, T. A., Brinkley, B. R., Bazett‐Jones, D. P., & Allis, C. D. (1997) · Chromosoma · doi:10.1007/s004120050256 · Cited by 1,860

Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome

Kornberg, R. D., & Lorch, Y. (1999) · Cell · doi:10.1016/s0092-8674(00)81958-3 · Cited by 1,833

Structure and ligand of a histone acetyltransferase bromodomain

Dhalluin, C., Carlson, J. E., Zeng, L., He, C., Aggarwal, A. K., Zhou, M.-M., & Zhou, M.-M. (1999) · Nature · doi:10.1038/20974 · Cited by 1,732

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.Preprint

Grant, P. A., Duggan, L. J., Côté, J., Roberts, S. M., Brownell, J. E., Candau, R., Ohba, R., Owen‐Hughes, T., Allis, C. D., Winston, F., et al. (1997) · Genes & Development · doi:10.1101/gad.11.13.1640 · Cited by 1,087

Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes

Hsu, J.-Y., Sun, Z., Li, X., Reuben, M., Tatchell, K., Bishop, D. K., Grushcow, J. M., Brame, C. J., Caldwell, J., Hunt, D. F., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00034-9 · Cited by 878

Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles

Roberts, C. J., Nelson, B., Marton, M. J., Stoughton, R. B., Meyer, M. R., Bennett, H. A., He, Y. D., Dai, H. A., Walker, W. L., Hughes, T. R., et al. (2000) · Science · doi:10.1126/science.287.5454.873 · Cited by 855

Structure and Function of a Human TAF II 250 Double Bromodomain Module

Jacobson, R. H., Ladurner, A. G., King, D., & Tjian, R. (2000) · Science · doi:10.1126/science.288.5470.1422 · Cited by 845

Synergistic Coupling of Histone H3 Phosphorylation and Acetylation in Response to Epidermal Growth Factor Stimulation

Cheung, P., Tanner, K. G., Cheung, W. L., Sassone‐Corsi, P., Denu, J. M., & Allis, C. D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80256-7 · Cited by 803

The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix.

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The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity

Mizzen, C. A., Yang, X., Kokubo, T., Brownell, J. E., Bannister, A. J., Owen‐Hughes, T., Workman, J. L., Wang, L., Berger, S. L., Kouzarides, T., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81821-8 · Cited by 724

Initiation of DNA Fragmentation during Apoptosis Induces Phosphorylation of H2AX Histone at Serine 139

Rogakou, E. P., Nieves‐Neira, W., Boon, C., Pommier, Y. G., & Bonner, W. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9390 · Cited by 721

Phosphorylation of Histone H3 Is Required for Proper Chromosome Condensation and Segregation

Wei, Y., Yu, L., Bowen, J. K., Gorovsky, M. A., & Allis, C. D. (1999) · Cell · doi:10.1016/s0092-8674(00)80718-7 · Cited by 719

ATP-dependent remodeling and acetylation as regulators of chromatin fluidityPreprint

Kingston, R. E., & Narlikar, G. J. (1999) · Genes & Development · doi:10.1101/gad.13.18.2339 · Cited by 702

Rad6-Dependent Ubiquitination of Histone H2B in Yeast

Robzyk, K., Recht, J., & Osley, M. A. (2000) · Science · doi:10.1126/science.287.5452.501 · Cited by 666

The stress-activated protein kinase pathways

Tibbles, L. A., & Woodgett, J. R. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050369 · Cited by 641

Phosphorylation of Serine 10 in Histone H3 Is Functionally Linked In Vitro and In Vivo to Gcn5-Mediated Acetylation at Lysine 14

Lo, W., Trievel, R. C., Rojas, J. R., Duggan, L. J., Hsu, J.-Y., Allis, C. D., Marmorstein, R., & Berger, S. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80257-9 · Cited by 573

Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena

Strahl, B. D., Ohba, R., Cook, R. G., & Allis, C. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14967 · Cited by 491

Requirement of Rsk-2 for Epidermal Growth Factor-Activated Phosphorylation of Histone H3

Sassone‐Corsi, P., Mizzen, C. A., Cheung, P., Crosio, C., Monaco, L., Jacquot, S., Hanauer, A., & Allis, C. D. (1999) · Science · doi:10.1126/science.285.5429.886 · Cited by 485

NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM‐related cofactor Tra1p

Allard, S., Utley, R. T., Savard, J., Clarke, A. S., Grant, P. A., Brandl, C. J., Pillus, L., Workman, J. L., & Côté, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5108 · Cited by 471

Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors

Mahadevan, L. C., Willis, A. C., & Barratt, M. J. (1991) · Cell · doi:10.1016/0092-8674(91)90385-c · Cited by 468

Identification of a Novel Phosphorylation Site on Histone H3 Coupled with Mitotic Chromosome Condensation

Goto, H., Kosako, H., Tomono, Y., Ajiro, K., Fujita, M., Sakurai, M., Okawa, K., Iwamatsu, A., Okigaki, T., Takahashi, T., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25543 · Cited by 458

The nucleosomal response associated with immediate‐early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG‐14 kinase

Thomson, S., Clayton, A. L., Hazzalin, C. A., Rose, S., Barratt, M. J., & Mahadevan, L. C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4779 · Cited by 451

Promoter targeting and chromatin remodeling by the SWI/SNF complex

Peterson, C. L., & Workman, J. L. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00068-x · Cited by 438

Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast

Kayne, P. S., Kim, U. J., Han, M., Mullen, J. R., Yoshizaki, F., & Grunstein, M. R. (1988) · Cell · doi:10.1016/0092-8674(88)90006-2 · Cited by 436

New Insights into the Control of MAP Kinase Pathways

English, J. M., Pearson, G. W., Wilsbacher, J. L., Swantek, J. L., Karandikar, M. S., Xu, S., & Cobb, M. H. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4687 · Cited by 434

Phosphorylation of histone H3 at serine 10 is correlated with chromosome condensation during mitosis and meiosis in Tetrahymena

Wei, Y., Mizzen, C. A., Cook, R. G., Gorovsky, M. A., & Allis, C. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7480 · Cited by 427

Phosphoacetylation of histone H3 on c‐fos‐ and c‐jun‐associated nucleosomes upon gene activation

Clayton, A. L., Rose, S., Barratt, M. J., & Mahadevan, L. C. (2000) · The EMBO Journal · doi:10.1093/emboj/19.14.3714 · Cited by 419

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeastPreprint

Biggins, S., Severin, F. F., Bhalla, N., Sassoon, I., Hyman, A. A., & Murray, A. W. (1999) · Genes & Development · doi:10.1101/gad.13.5.532 · Cited by 401

An Enzymatic Activity in the Yeast Sir2 Protein that Is Essential for Gene Silencing

Tanny, J. C., Dowd, G. J., Huang, J., Hilz, H., & Moazed, D. (1999) · Cell · doi:10.1016/s0092-8674(00)81671-2 · Cited by 391

Whole-genome expression analysis of snf/swi mutants of Saccharomyces cerevisiae

Sudarsanam, P., Iyer, V. R., Brown, P. O., & Winston, F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3364 · Cited by 389

Reversible histone modification and the chromosome cell cycle

Bradbury, E. M. (1992) · BioEssays · doi:10.1002/bies.950140103 · Cited by 367

Use of selectively trypsinized nucleosome core particles to analyze the role of the histone “tails” in the stabilization of the nucleosome

Ausió, J., Dong, F., & Holde, K. E. V. (1989) · Journal of Molecular Biology · doi:10.1016/0022-2836(89)90493-2 · Cited by 334

Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase

Osmani, S. A., Pu, R. T., & Morris, N. R. (1988) · Cell · doi:10.1016/0092-8674(88)90385-6 · Cited by 328

MITOTIC CHROMOSOME CONDENSATION

Koshland, D. E., & Strunnikov, A. V. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.305 · Cited by 323

Signaling routes to CREM and CREB: plasticity in transcriptional activation

Cesare, D. D., Fimia, G. M., & Sassone‐Corsi, P. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01414-0 · Cited by 310

Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c- fos gene

Cesare, D. D., Jacquot, S., Hanauer, A., & Sassone‐Corsi, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12202 · Cited by 309

Regulation of the mRNA levels of nimA, a gene required for the G2-M transition in Aspergillus nidulans.

Osmani, S. A., May, G. S., & Morris, N. R. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.104.6.1495 · Cited by 297

The Human Homologue of the Yeast Proteins Skb1 and Hsl7p Interacts with Jak Kinases and Contains Protein Methyltransferase Activity

Pollack, B. P., Kotenko, S. V., He, W., Izotova, L. S., Barnoski, B. L., & Pestka, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31531 · Cited by 290

The bromodomain: a chromatin-targeting module?

Winston, F., & Allis, C. D. (1999) · Nature Structural Biology · doi:10.1038/10640 · Cited by 282

The bromodomain revisited

Jeanmougin, F. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01042-6 · Cited by 279

Increased Ser-10 Phosphorylation of Histone H3 in Mitogen-stimulated and Oncogene-transformed Mouse Fibroblasts

Chadee, D. N., Hendzel, M. J., Tylipski, C. P., Allis, C. D., Bazett‐Jones, D. P., Wright, J. A., & Davie, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24914 · Cited by 276

Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation.

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The Signal-Dependent Coactivator CBP Is a Nuclear Target for pp90RSK

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The Survivin-like C. elegans BIR-1 Protein Acts with the Aurora-like Kinase AIR-2 to Affect Chromosomes and the Spindle Midzone

Speliotes, E. K., Uren, A. G., Vaux, D. L., & Horvitz, H. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00023-x · Cited by 249

Global Role for Chromatin Remodeling Enzymes in Mitotic Gene Expression

Krebs, J. E., Fry, C. J., Samuels, M. L., & Peterson, C. L. (2000) · Cell · doi:10.1016/s0092-8674(00)00081-7 · Cited by 237

MAP kinase-mediated signalling to nucleosomes and immediate-early gene induction

Thomson, S., Mahadevan, L. C., & Clayton, A. L. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1999.0302 · Cited by 225

NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1

Helps, N. R., Luo, X., Barker, H. M., & Cohen, P. T. W. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3490509 · Cited by 214

A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae.Preprint

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Mitotic Histone H3 Phosphorylation by the NIMA Kinase in Aspergillus nidulans

Souza, C. P. C. D., Osmani, A. H., Wu, L.-P., Spotts, J. L., & Osmani, S. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00035-0 · Cited by 158

Mitogen-stimulated phosphorylation of histone H3 is targeted to a small hyperacetylation-sensitive fraction.

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BIRinging Chromosomes through Cell Division—And Survivin' the Experience

Reed, J. C., & Bischoff, J. R. (2000) · Cell · doi:10.1016/s0092-8674(00)00076-3 · Cited by 151

Patterns of histone acetylation.

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The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases.

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Role of histone tails in nucleosome remodeling by Drosophila NURF

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Identification of a non‐basic domain in the histone H4 N‐terminus required for repression of the yeast silent mating loci.

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Histone H2B Phosphorylation in Mammalian Apoptotic Cells

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Localization of the sites along nucleosome DNA which interact with NH2-terminal histone regions.

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The bromodomain of Gcn5p interacts in vitro with specific residues in the N terminus of histone H4 1 1Edited by T. Richmond

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Phosphorylation of Linker Histone H1 Regulates Gene Expression In Vivo by Creating a Charge Patch

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Histone structure and function

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Hsl7p, the Yeast Homologue of Human JBP1, Is a Protein Methyltransferase

Lee, J., Cook, J. R., Pollack, B. P., Kinzy, T. G., Norris, D., & Pestka, S. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3049 · Cited by 59

Chromatin (Springer Series in Molecular Biology)

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Studies of Nucleosome StructurePreprint

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Kinase Activity and Phosphorylation of the Largest Subunit of TFIIF Transcription Factor

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hSWI/SNF Disrupts Interactions between the H2A N-Terminal Tail and Nucleosomal DNA

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Phosphorylation of histones in cells treated with hypertonic and acidic media.

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Translating the Histone Code

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., & Jenuwein, T. (2001) · Nature · doi:10.1038/35065132 · Cited by 2,868

Active Genes Are Tri-Methylated at K4 of Histone H3

Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C. T., Schreiber, S. L., Mellor, J., & Kouzarides, T. (2002) · Nature · doi:10.1038/nature01080 · Cited by 2,138

Histone Acetyltransferases

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The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

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Signal transduction from cell surface to nucleus in development and disease

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Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

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Signal transduction and gene control

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Histone Phosphorylation

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Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors

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