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TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice
Open accessAbstract
TGFbeta1 has been implicated in cell cycle control and carcinogenesis. To address the exact function of TGFbeta1 in skin carcinogenesis in vivo, mice with TGFbeta1 expression targeted to keratinocytes were subjected to long-term chemical carcinogenesis treatment. TGFbeta1 showed biphasic action during multistage skin carcinogenesis, acting early as a tumor suppressor but later enhancing the malignant phenotype. The transgenics were more resistant to induction of benign skin tumors than controls, but the malignant conversion rate was vastly increased. There was also a higher incidence of spindle cell carcinomas, which expressed high levels of endogenous TGFbeta3, suggesting that TGFbeta1 elicits an epithelial-mesenchymal transition in vivo and that TGFbeta3 might be involved in maintenance of the spindle cell phenotype. The action of TGFbeta1 in enhancing malignant progression may mimic its proposed function in modulating epithelial cell plasticity during embryonic development.
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“However, TGF-β3 is clearly expressed by stromal CAFs and mesenchymal tumor cells41,70,247”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [41]
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Cites
Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U., Liotta, L. A., Falanga, V., & Kehrl, J. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4167 · Cited by 2,867
Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability
Markowitz, S. D., Wang, J., Myeroff, L. L., Parsons, R. E., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., et al. (1995) · Science · doi:10.1126/science.7761852 · Cited by 2,267
Kaartinen, V., Voncken, J. W., Shuler, C. F., Warburton, D., Bu, D., Heisterkamp, N., & Groffen, J. (1995) · Nature Genetics · doi:10.1038/ng1295-415 · Cited by 1,042
Miettinen, P. J., Ebner, R., Lopez, A. R., & Derynck, R. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.6.2021 · Cited by 939
Transforming growth factor–β3 is required for secondary palate fusion
Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J., & Doetschman, T. (1995) · Nature Genetics · doi:10.1038/ng1295-409 · Cited by 908
Derynck, R., Goeddel, D. V., Ullrich, A., Gutterman, J. U., Williams, R. D., Bringman, T. S., & Berger, W. H. (1987) · PubMed · Cited by 898
Kimelman, D., & Kirschner, M. W. (1987) · Cell · doi:10.1016/0092-8674(87)90110-3 · Cited by 872
The Transforming Growth Factor-βs
Roberts, A. B., & Sporn, M. B. (1991) · Springer eBooks · doi:10.1007/978-1-4612-3210-0_8 · Cited by 869
The Transforming Growth Factor-βs
Roberts, A. B., & Sporn, M. B. (1990) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-49295-2_8 · Cited by 744
Ansari, B., Coates, P. J., Greenstein, B., & Hall, P. A. (1993) · The Journal of Pathology · doi:10.1002/path.1711700102 · Cited by 578
Research works printed but not linked: 11
- Arteaga, 1990, Growth stimulation of human breast cancer cells with anti-transforming growth factor β antibodies, Cell Growth Differ., 1, 367
- Caulin, 1995, Chronic exposure of cultured transfected mouse epidermal cells to TGFβ1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype, Cell Growth Differ., 6, 1027
- Cui, W., and Akhurst, R.J. (1996). Transforming growth factors β: biochemistry and biology in vitro and in vivo. In Growth Factors and Cytokines in Health and Disease, C. Bondy and D. LeRoith, eds. (Greenwich, Connecticut: JAI Press), in press.
- Cui, 1994, Lack of TGFβ1 expression in benign skin tumours of p53 null mice is prognostic for a high risk of malignant conversion, Cancer Res., 54, 5831
- Dlugosz, 1995, Autocrine transforming growth factor α is dispensible for v-ras-Ha-induced epidermal neoplasia, Cancer Res., 55, 1883
- Fowlis, 1992, Discordant TGFβ1 RNA and protein localisations during chemical carcinogenesis of the skin, Cell Growth Differ., 3, 81
- Fowlis, 1996, Altered epidermal growth control in vivo in transgenic mice expressing TGFβ1 from an inducible keratin gene promoter, Cell Growth Differ., 7, 679
- Gomella, 1989, Expression of transforming growth factor α in normal adult kidney and enhanced expression of transforming growth factors α and β in renal cell carcinoma, Cancer Res., 49, 6972
- Manning, 1991, Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor β (TGF-β), Oncogene, 6, 1471
- Steiner, 1992, Transforming growth factor-β-1 overproduction in prostate cancer, Mol. Endocrinol., 6, 15
- Tennenbaum, 1992, Extracellular matrix receptors and mouse skin carcinogenesis, Cancer Res., 52, 2966
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Chua, D. T. T., Fasching, P. A., Ma, B. B. Y., Thongprasert, S., & Wirth, L. J. (2009) · Journal of Oncology · doi:10.1155/2009/157964 · Cited by 2
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Crescenzo, G. D., Chao, H., Zwaagstra, J. C., Durocher, Y., & O'Connor‐McCourt, M. D. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-293-9_40 · Cited by 2
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Goh, N. L. L.-A., Rahim, N. J. A., Bhatt, R., Ong, S. E., Lim, K. Y., Gandini, A., Zeng, Z., Kumari, S., & Gabrielli, B. G. (2025) · Cancers · doi:10.3390/cancers17111817 · Cited by 1
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Kerkelä, E. (2001) · Työväentutkimus Vuosikirja
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Diez-Cuñado, M. (2010) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
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Tan, E. (2013) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Qing, J., & Derynck, R. (2005) · The Cancer Handbook · doi:10.1002/0470025077.chap13
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Jensen, L. D. (2010) · Figshare
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Pinkas, J., & Teicher, B. A. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-035-5_25
Perturbation of EGF-induced MAP kinase activation by TGF-ß1
Wenner, C. E., & Yan, S. (1999) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1999000700004
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Wendt, M. K., & Schiemann, W. P. (2011) · Springer eBooks · doi:10.1007/978-94-007-2558-4_5
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Heldin, C. H. (2001) · Springer eBooks · doi:10.1007/978-3-662-04645-6_1
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Bornstein, S., Han, G., Hoot, K. E., Lu, S., & Wang, X. (2009) · Springer eBooks · doi:10.1007/978-4-431-88663-1_5
Amiri, M. (2014) · Scholarship@Western (Western University)
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Franzén, Å. (2002) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Glick, A. B., Bae, D., Liu, X., & Vijayachandra, K. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-292-2_19
McCutcheon, L. J. G. (2009) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
TGFβ signal transduction in endothelial cells.
Valdimarsdóttir, G. (2004) · Uppsala University Publications (Uppsala University)
Shiou, S. (2006) · Europe PMC (PubMed Central)
Novel aspects of TGFβ in human CD4 + T cell biology
Bonn, R. F.-W.-U. (2008)
TGFβ Receptor Signaling in Cancer and Metastasis
Oft, M. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48399-8_9
Brett, A. (2012) · OhioLink ETD Center (Ohio Library and Information Network)
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Fonsatti, E., & Maio, M. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-292-2_25
Becker‐Santos, D. D. (2011) · Open Collections · doi:10.14288/1.0071651
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Family, H. D. (2012)
Current state of the evolving MMMN cancer progression models of cancer
Thiagalingam, S. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9780511979811.022
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Inglese, C. N. (2016) · QSpace (Queen's University Library)
to the extracellular matrix and effects on cell adhesion
Hyytiäinen, M. M. (2004)
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Carrière, C., & Korc, M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00310-7
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Herzig, M., & Christofori, G. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-313-2_13
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Singh, G. (2010) · Publikationsserver (Universitat Marburg) · doi:10.17192/z2010.0267
Molecular Organization of Cells
Ahlstrom, J. D. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385942-6.00006-8
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Matise, L. A. (2012)
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Bjerke, G. A. (2013) · doi:10.18130/v39z2h
TGFβ Signaling in Head and Neck Cancer Development and Metastases
Malkoski, S. P., Lighthall, J. G., & Wang, X.-J. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0775-2_8
AP-1 regulation during malignant progression of mouse keratinocyte cells
Joseloff, E. (1997) · UA Campus Repository (The University of Arizona)
Rees, J. L. (2004) · Wiley eBooks · doi:10.1002/9780470750520.ch8
Molecular Organization of Cells
Ahlstrom, J. D., & Erickson, C. A. (2008) · Elsevier eBooks · doi:10.1016/b978-012369410-2.50006-1
Molecular Organization of Cells
Ahlstrom, J. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809880-6.00001-1
Hesketh, R. (1997) · Elsevier eBooks · doi:10.1016/b978-012344548-3/50088-1
Tumor Microenvironment: Coconspirator in Tumorigenesis
Wang, Z. (2022) · Springer eBooks · doi:10.1007/978-3-030-93084-4_3
Andarawewa, K. L., Erickson, A., Chou, W. S., Costes, S. V., Gascard, P. D., Mott, J. D., Bissell, M. J., & Barcellos‐Hoff, M. H. (2023) · doi:10.1158/0008-5472.c.6496256.v1
Andarawewa, K. L., Erickson, A., Chou, W. S., Costes, S. V., Gascard, P. D., Mott, J. D., Bissell, M. J., & Barcellos‐Hoff, M. H. (2023) · doi:10.1158/0008-5472.c.6496256
Kanies, C. L., Smith, J. J., Kis, C., Schmidt, C. R., Levy, S., Khabar, K. S. A., Morrow, J. D., Deane, N. G., Dixon, D. A., & Beauchamp, R. D. (2023) · doi:10.1158/1541-7786.c.6542217
Markell, L. M., Masiuk, K. E., Blazanin, N., & Glick, A. B. (2023) · doi:10.1158/1541-7786.c.6541939
Markell, L. M., Masiuk, K. E., Blazanin, N., & Glick, A. B. (2023) · doi:10.1158/1541-7786.c.6541939.v1
Metadata
- Authors
- Cui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A., & Akhurst, R. J.
- Affiliations
- University of Glasgow (GB)
- Corresponding author
- Akhurst, Rosemary J
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-08
- Volume
- 86
- Issue
- 4
- Pages
- 531-542
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2026460094
- Cited by
- 628
- References
- 98
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 10 · 2023: 20 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 13 · 2017: 12 · 2016: 9 · 2015: 15 · 2014: 22 · 2013: 22 · 2012: 26
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
- Keywords
- TGF-β1, skin carcinogenesis, sarcomatoid carcinoma, keratinocytes, tumor suppressor, malignant progression, TGF-beta3, epithelial-mesenchymal transition, chemical carcinogenesis, transgenic mice, epithelial cell plasticity
- MeSH terms
- Animals, Carcinoma, Carcinoma, Squamous Cell, Cells, Cultured, Female, Immunologic Techniques, Keratins, Mice, Transgenic, Papilloma, Skin Neoplasms, Integrins, Transforming Growth Factor beta, Mice
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