The DOI matches its Crossref record; 97 of the 98 references it cites were found in a registry or an index.
TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice
Open accessAbstract
TGFbeta1 has been implicated in cell cycle control and carcinogenesis. To address the exact function of TGFbeta1 in skin carcinogenesis in vivo, mice with TGFbeta1 expression targeted to keratinocytes were subjected to long-term chemical carcinogenesis treatment. TGFbeta1 showed biphasic action during multistage skin carcinogenesis, acting early as a tumor suppressor but later enhancing the malignant phenotype. The transgenics were more resistant to induction of benign skin tumors than controls, but the malignant conversion rate was vastly increased. There was also a higher incidence of spindle cell carcinomas, which expressed high levels of endogenous TGFbeta3, suggesting that TGFbeta1 elicits an epithelial-mesenchymal transition in vivo and that TGFbeta3 might be involved in maintenance of the spindle cell phenotype. The action of TGFbeta1 in enhancing malignant progression may mimic its proposed function in modulating epithelial cell plasticity during embryonic development.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, TGF-β3 is clearly expressed by stromal CAFs and mesenchymal tumor cells41,70,247”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [41]
Citations
Cites
Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U., Liotta, L. A., Falanga, V., & Kehrl, J. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4167 · Cited by 2,867
Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability
Markowitz, S. D., Wang, J., Myeroff, L. L., Parsons, R. E., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., et al. (1995) · Science · doi:10.1126/science.7761852 · Cited by 2,267
Kaartinen, V., Voncken, J. W., Shuler, C. F., Warburton, D., Bu, D., Heisterkamp, N., & Groffen, J. (1995) · Nature Genetics · doi:10.1038/ng1295-415 · Cited by 1,042
Miettinen, P. J., Ebner, R., Lopez, A. R., & Derynck, R. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.6.2021 · Cited by 939
Transforming growth factor–β3 is required for secondary palate fusion
Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J., & Doetschman, T. (1995) · Nature Genetics · doi:10.1038/ng1295-409 · Cited by 908
Derynck, R., Goeddel, D. V., Ullrich, A., Gutterman, J. U., Williams, R. D., Bringman, T. S., & Berger, W. H. (1987) · PubMed · Cited by 898
Kimelman, D., & Kirschner, M. W. (1987) · Cell · doi:10.1016/0092-8674(87)90110-3 · Cited by 872
The Transforming Growth Factor-βs
Roberts, A. B., & Sporn, M. B. (1991) · Springer eBooks · doi:10.1007/978-1-4612-3210-0_8 · Cited by 869
The Transforming Growth Factor-βs
Roberts, A. B., & Sporn, M. B. (1990) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-49295-2_8 · Cited by 744
Ansari, B., Coates, P. J., Greenstein, B., & Hall, P. A. (1993) · The Journal of Pathology · doi:10.1002/path.1711700102 · Cited by 578
Research works printed but not linked: 11
- Arteaga, 1990, Growth stimulation of human breast cancer cells with anti-transforming growth factor β antibodies, Cell Growth Differ., 1, 367
- Caulin, 1995, Chronic exposure of cultured transfected mouse epidermal cells to TGFβ1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype, Cell Growth Differ., 6, 1027
- Cui, W., and Akhurst, R.J. (1996). Transforming growth factors β: biochemistry and biology in vitro and in vivo. In Growth Factors and Cytokines in Health and Disease, C. Bondy and D. LeRoith, eds. (Greenwich, Connecticut: JAI Press), in press.
- Cui, 1994, Lack of TGFβ1 expression in benign skin tumours of p53 null mice is prognostic for a high risk of malignant conversion, Cancer Res., 54, 5831
- Dlugosz, 1995, Autocrine transforming growth factor α is dispensible for v-ras-Ha-induced epidermal neoplasia, Cancer Res., 55, 1883
- Fowlis, 1992, Discordant TGFβ1 RNA and protein localisations during chemical carcinogenesis of the skin, Cell Growth Differ., 3, 81
- Fowlis, 1996, Altered epidermal growth control in vivo in transgenic mice expressing TGFβ1 from an inducible keratin gene promoter, Cell Growth Differ., 7, 679
- Gomella, 1989, Expression of transforming growth factor α in normal adult kidney and enhanced expression of transforming growth factors α and β in renal cell carcinoma, Cancer Res., 49, 6972
- Manning, 1991, Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor β (TGF-β), Oncogene, 6, 1471
- Steiner, 1992, Transforming growth factor-β-1 overproduction in prostate cancer, Mol. Endocrinol., 6, 15
- Tennenbaum, 1992, Extracellular matrix receptors and mouse skin carcinogenesis, Cancer Res., 52, 2966
Cited by
Sorted by citations
The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196
Epithelial–mesenchymal transitions in tumour progression
Thiery, J. P. (2002) · Nature reviews. Cancer · doi:10.1038/nrc822 · Cited by 6,767
TGF-β signalling from cell membrane to nucleus through SMAD proteins
Heldin, C., Miyazono, K., & ten Dijke, P. (1997) · Nature · doi:10.1038/37284 · Cited by 3,697
TGF-β-induced epithelial to mesenchymal transition
Xu, J., Lamouille, S., & Derynck, R. (2009) · Cell Research · doi:10.1038/cr.2009.5 · Cited by 2,804
Role of Transforming Growth Factor β in Human Disease
Blobe, G. C., Schiemann, W. P., & Lodish, H. F. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421807 · Cited by 2,453
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
Massagué, J., Blain, S. W., & Lo, R. S. (2000) · Cell · doi:10.1016/s0092-8674(00)00121-5 · Cited by 2,391
TGF-β Signaling in Tumor Suppression and Cancer Progression
Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275
Self-citationCytostatic and apoptotic actions of TGF-β in homeostasis and cancer
Siegel, P. M., & Massagué, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1208 · Cited by 1,626
TGF-β and epithelial-to-mesenchymal transitions
Zavadil, J., & Böttinger, E. P. (2005) · Oncogene · doi:10.1038/sj.onc.1208927 · Cited by 1,628
Regulation of matrix metalloproteinase expression in tumor invasion
Westermarck, J. K., & Kähäri, V. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.8.781 · Cited by 1,494
Targeting the TGFβ signalling pathway in disease
Akhurst, R. J., & Hata, A. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3810 · Cited by 1,466
Self-citationTGFβ: the molecular Jekyll and Hyde of cancer
Bierie, B., & Moses, H. L. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1926 · Cited by 1,291
TGF-β signaling in health, disease and therapeutics
Deng, Z., Fan, T. T., Chu, X., Tian, H., Zheng, Y., Li, C., & He, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01764-w · Cited by 1,360
Cyclosporine induces cancer progression by a cell-autonomous mechanism
Hojo, M., Morimoto, T., Maluccio, M. A., Asano, T., Morimoto, K., Lagman, M., Shimbo, T., & Suthanthiran, M. (1999) · Nature · doi:10.1038/17401 · Cited by 1,148
Regulation of matrix metalloproteinases: An overview
Chakraborti, S., Mandal, M., Das, S. K., Mandal, A., & Chakraborti, T. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1026028303196 · Cited by 1,123
Role of tissue stroma in cancer cell invasion
De Wever, O., & Mareel, M. (2003) · The Journal of Pathology · doi:10.1002/path.1398 · Cited by 1,042
Bhowmick, N., Ghiassi, M., Bakin, A. V., Aakre, M., Lundquist, C., Engel, M., Arteaga, C., & Moses, H. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.1.27 · Cited by 1,087
A mechanism of repression of TGFbeta / Smad signaling by oncogenic RasPreprint
Kretzschmar, M., Doody, J. F., Timokhina, I., & Massagué, J. (1999) · Genes & Development · doi:10.1101/gad.13.7.804 · Cited by 997
Bakin, A. V., Tomlinson, A. K., Bhowmick, N. A., Moses, H. L., & Arteaga, C. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005912200 · Cited by 1,008
Yin, J. J., Selander, K. S., Chirgwin, J. M., Dallas, M., Grubbs, B. G., Wieser, R., Massagué, J., Mundy, G. R., & Guise, T. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci3523 · Cited by 988
TGFβ biology in cancer progression and immunotherapy
Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944
Self-citationSnail blocks the cell cycle and confers resistance to cell deathPreprint
Vega, S., Morales, A. V., Ocaña, O. H., Valdés, F., Fabregat, I., & Nieto, M. A. (2004) · Genes & Development · doi:10.1101/gad.294104 · Cited by 866
Padua, D. M., & Massagué, J. (2008) · Cell Research · doi:10.1038/cr.2008.316 · Cited by 828
Moustakas, A., & Heldin, C. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00550.x · Cited by 798
A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis
Adorno, M., Cordenonsi, M., Montagner, M., Dupont, S., Wong, C., Hann, B. C., Solari, A., Bobisse, S., Rondina, M. B., Guzzardo, V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.01.039 · Cited by 794
Self-citationT he P athogenesis of O ral L ichen P lanus
Sugerman, P. B., Savage, N. W., Walsh, L. J., Zhao, Z. Z., Zhou, X. J., Khan, A., Seymour, G. J., & Bigby, M. E. (2002) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130201300405 · Cited by 780
Integration of TGF‐β/Smad and Jagged1/Notch signalling in epithelial‐to‐mesenchymal transition
Zavadil, J., C̆ermák, L., Soto-Nieves, N., & Böttinger, E. P. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600069 · Cited by 742
TGF-β Superfamily Signaling in Embryonic Development and Homeostasis
Wu, M., & Hill, C. S. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.012 · Cited by 743
Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity
Pepper, M. S. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(96)00048-2 · Cited by 737
Massagué, J., & Gomis, R. R. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.033 · Cited by 741
Role of Transforming Growth Factor Beta in Human Cancer
Elliott, R. L., & Blobe, G. C. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.047 · Cited by 717
Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis
Janda, E., Lehmann, K. E., Killisch, I., Jechlinger, M., Herzig, M., Downward, J., Beug, H., & Grünert, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200109037 · Cited by 702
Mechanisms of Immune Evasion by Tumors
Drake, C. G., Jaffee, E. M., & Pardoll, D. M. (2006) · Advances in immunology · doi:10.1016/s0065-2776(06)90002-9 · Cited by 716
Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis
Grünert, S., Jechlinger, M., & Beug, H. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1175 · Cited by 682
Voulgari, A., & Pintzas, A. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.03.002 · Cited by 683
Transforming Growth Factor β-1 Induces Snail Transcription Factor in Epithelial Cell Lines
Peinado, H., Quintanilla, M., & Cano, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211304200 · Cited by 642
Razani, B., Zhang, X. L., Bitzer, M., von Gersdorff, G., Böttinger, E. P., & Lisanti, M. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008340200 · Cited by 640
TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
Oft, M., Heider, K., & Beug, H. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00533-7 · Cited by 624
Valcourt, U., Kowanetz, M., Niimi, H., Heldin, C., & Moustakas, A. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0658 · Cited by 631
Development of TGF-β signalling inhibitors for cancer therapy
Yingling, J. M., Blanchard, K. L., & Sawyer, J. S. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1580 · Cited by 557
Barcellos‐Hoff, M. H., & Ravani, S. A. (2000) · PubMed · Cited by 536
Alterations in components of the TGF-β superfamily signaling pathways in human cancer
LEVY, L., & HILL, C. (2006) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.09.009 · Cited by 539
Genetic programs of epithelial cell plasticity directed by transforming growth factor-β
Zavadil, J., Bitzer, M., Liang, D., Yang, Y.-C., Massimi, A. B., Kneitz, S., Piek, E., & Böttinger, E. P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111614398 · Cited by 534
Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
Pardali, K., & Moustakas, A. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.06.004 · Cited by 549
TGF- : Duality of Function Between Tumor Prevention and Carcinogenesis
Principe, D. R., Doll, J. A., Bauer, J. I., Jung, B., Munshi, H. G., Bartholin, L., Pasche, B., Lee, C., & Grippo, P. J. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt369 · Cited by 537
Transforming growth factor-β in cancer and metastasis
Jakowlew, S. B. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-9006-2 · Cited by 529
TGF-β – an excellent servant but a bad master
Kubiczkova, L., Sedlarikova, L., Hajek, R., & Sevcikova, S. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-183 · Cited by 511
Regulation of EMT by TGFβ in cancer
Heldin, C., Vanlandewijck, M., & Moustakas, A. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.02.037 · Cited by 502
Khan, R., & Sheppard, R. J. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02336.x · Cited by 505
Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases
Muraoka, R. S., Dumont, N., Ritter, C. A., Dugger, T. C., Brantley, D. M., Chen, J., Easterly, E., Roebuck, L. R., Ryan, S. T., Gotwals, P. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15234 · Cited by 522
TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma
Oshimori, N., Oristian, D., & Fuchs, E. (2015) · Cell · doi:10.1016/j.cell.2015.01.043 · Cited by 471
Derynck, R., & Feng, X. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(97)00017-6 · Cited by 440
Bakin, A. V., Rinehart, C., Tomlinson, A. K., & Arteaga, C. L. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.15.3193 · Cited by 429
Piek, E., Moustakas, A., Kurisaki, A., Heldin, C., & ten Dijke, P. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.24.4557 · Cited by 427
The influence of the microenvironment on the malignant phenotype
Park, C. C., Bissell, M. J., & Barcellos-Hoff, M. H. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(00)01756-1 · Cited by 398
TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression
Tang, B., Vu, M. A., Booker, T., Santner, S. J., Miller, F. R., Anver, M. R., & Wakefield, L. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18899 · Cited by 394
N-Glycans in cancer progression
Lau, K. S., & Dennis, J. W. (2008) · Glycobiology · doi:10.1093/glycob/cwn071 · Cited by 390
The dynamic roles of TGF‐β in cancer
Meulmeester, E., & ten Dijke, P. (2010) · The Journal of Pathology · doi:10.1002/path.2785 · Cited by 399
Maeda, M., Johnson, K. R., & Wheelock, M. J. (2005) · Journal of Cell Science · doi:10.1242/jcs.01634 · Cited by 393
Poltavets, V., Kochetkova, M., Pitson, S. M., & Samuel, M. S. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00431 · Cited by 377
Metastasis is driven by sequential elevation of H-ras and Smad2 levels
Oft, M., Akhurst, R. J., & Balmain, A. (2002) · Nature Cell Biology · doi:10.1038/ncb807 · Cited by 377
Self-citationAutocrine PDGFR signaling promotes mammary cancer metastasis
Jechlinger, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24652 · Cited by 381
Deckers, M., van Dinther, M., Buijs, J., Que, I., Löwik, C., van der Pluijm, G., & ten Dijke, P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3560 · Cited by 379
Tse, J. C., & Kalluri, R. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21215 · Cited by 381
Thuault, S., Tan, E., Peinado, H., Cano, A., Heldin, C., & Moustakas, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802016200 · Cited by 365
Ellenrieder, V., Hendler, S. F., Boeck, W., Seufferlein, T., Menke, A., Ruhland, C., Adler, G., & Gress, T. M. (2001) · PubMed · Cited by 361
Latent TGF-β Binding Proteins: Extracellular Matrix Association and Roles in TGF-β Activation
Hyytiäinen, M. M., Penttinen, C., & Keski‐Oja, J. (2004) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360490460933 · Cited by 351
Complexities of TGF-β Targeted Cancer Therapy
Connolly, E. C., Freimuth, J., & Akhurst, R. J. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4564 · Cited by 354
Self-citationTumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?
Micke, P., & tman, A. (2004) · Lung Cancer · doi:10.1016/j.lungcan.2004.07.977 · Cited by 346
Lévy, L., & Hill, C. S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8108-8125.2005 · Cited by 354
TGF-beta in CAF-mediated tumor growth and metastasis
Calon, A., Tauriello, D. V. F., & Batlle, E. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.12.008 · Cited by 342
Cellular and molecular mechanisms of action of bisphosphonates
Rogers, M. J., Gordon, S., Benford, H. L., Coxon, F. P., Luckman, S. P., Mönkkönen, J., & Frith, J. C. (2000) · Cancer · doi:10.1002/1097-0142(20000615)88:12+ · Cited by 982
Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency
Tang, B., Böttinger, E. P., Jakowlew, S. B., Bagnall, K. M., Mariano, J. M., Anver, M. R., Letterio, J. J., & Wakefield, L. M. (1998) · Nature Medicine · doi:10.1038/nm0798-802 · Cited by 315
Epithelial–mesenchymal transition in ovarian cancer
Vergara, D., Merlot, B., Lucot, J.-P., Collinet, P., Vinatier, D., Fournier, I., & Salzet, M. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.09.017 · Cited by 307
Stem cells: the intestinal stem cell as a paradigm
Bach, S. P., Renehan, A. G., & Potten, C. S. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.469 · Cited by 236
Freudlsperger, C., Bian, Y., Wise, S. C., Burnett, J., Coupar, J. F., Yang, X., Chen, Z., & Waes, C. V. (2012) · Oncogene · doi:10.1038/onc.2012.171 · Cited by 290
Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas
Braun, J., Hoang‐Vu, C., Dralle, H., & Hüttelmaier, S. (2010) · Oncogene · doi:10.1038/onc.2010.169 · Cited by 281
Guasch, G., Schöber, M., Pasolli, H. A., Conn, E. B., Polak, L., & Fuchs, E. V. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.020 · Cited by 271
PIN1, the cell cycle and cancer
Yeh, E. S., & Means, A. R. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2107 · Cited by 268
Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression
Taniguchi, S., Elhance, A., Duzer, A. V., Kumar, S., Leitenberger, J. J., & Oshimori, N. (2020) · Science · doi:10.1126/science.aay1813 · Cited by 266
The emerging role of TGF-β superfamily coreceptors in cancer
Bernabéu, C., López-Novoa, J. M., & Quintanilla, M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.07.003 · Cited by 264
Barcellos‐Hoff, M. H., & Brooks, A. L. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)156[0618:esttma]2.0.co;2 · Cited by 251
Transforming growth factor-β and the hallmarks of cancer
Tian, M., Neil, J. R., & Schiemann, W. P. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.10.015 · Cited by 254
Th1 cytokines in oral lichen planus
Khan, A., Farah, C. S., Savage, N. W., Walsh, L. J., Harbrow, D. J., & Sugerman, P. B. (2003) · Journal of Oral Pathology and Medicine · doi:10.1034/j.1600-0714.2003.00077.x · Cited by 243
Targeting the TGFβ signaling network in human neoplasia
Dumont, N., & Arteaga, C. L. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00135-1 · Cited by 243
Genealogy, expression, and cellular function of transforming growth factor-β
Govinden, R., & Bhoola, K. D. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00035-4 · Cited by 248
Role of Rho family GTPases in epithelial morphogenesis.Preprint
Aelst, L. V., & Symons, M. (2002) · Genes & Development · doi:10.1101/gad.978802 · Cited by 247
Chen, F., Mrock, L. K., & Ireland, M. E. (2001) · Journal of Cellular Physiology · doi:10.1002/1097-4652(200002)186:2 · Cited by 11
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds
Ang, H. L., Mohan, C. D., Shanmugam, M. K., Leong, H. C., Makvandi, P., Rangappa, K. S., Bishayee, A., Kumar, A. P., & Sethi, G. (2023) · Medicinal Research Reviews · doi:10.1002/med.21948 · Cited by 234
GATA3 Inhibits Breast Cancer Metastasis through the Reversal of Epithelial-Mesenchymal Transition
Yan, W., Cao, Q. J., Arenas, R. B., Bentley, B., & Shao, R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.105262 · Cited by 227
Seton-Rogers, S. E., Lu, Y., Hines, L. M., Koundinya, M., LaBaer, J., Muthuswamy, S. K., & Brugge, J. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308090100 · Cited by 224
Han, G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24399 · Cited by 224
TGF β Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis
Papageorgis, P. (2015) · Journal of Oncology · doi:10.1155/2015/587193 · Cited by 228
TGF- β signaling in cancer – a double-edged sword
Akhurst, R. J., & Derynck, R. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02130-4 · Cited by 756
Self-citationGrände, M., Franzén, Å., Karlsson, J.-O., Ericson, L. E., Heldin, N., & Nilsson, M. (2002) · Journal of Cell Science · doi:10.1242/jcs.00091 · Cited by 215
Szweras, M., Liu, D., Partridge, E. A., Pawling, J., Sukhu, B., Clokie, C. M. L., Jahnen‐Dechent, W., Tenenbaum, H. C., Swallow, C. J., Grynpas, M. D., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112234200 · Cited by 214
Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression
Wendt, M. K., Tian, M., & Schiemann, W. P. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1199-1 · Cited by 215
Taipale, J., Saharinen, J., & Keski‐Oja, J. (1998) · Advances in cancer research · doi:10.1016/s0065-230x(08)60740-x · Cited by 209
Integrin-mediated activation of latent transforming growth factor β
Sheppard, D. (2005) · Cancer and Metastasis Reviews · doi:10.1007/s10555-005-5131-6 · Cited by 213
The TGF-β Paradox in Human Cancer: An Update
Tian, M., & Schiemann, W. P. (2009) · Future Oncology · doi:10.2217/14796694.5.2.259 · Cited by 200
Metadata
- Authors
- Cui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A., & Akhurst, R. J.
- Affiliations
- University of Glasgow (GB)
- Corresponding author
- Akhurst, Rosemary J
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-08
- Volume
- 86
- Issue
- 4
- Pages
- 531-542
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2026460094
- Cited by
- 628
- References
- 98
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 10 · 2023: 20 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 13 · 2017: 12 · 2016: 9 · 2015: 15 · 2014: 22 · 2013: 22 · 2012: 26
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
- Keywords
- TGF-β1, skin carcinogenesis, sarcomatoid carcinoma, keratinocytes, tumor suppressor, malignant progression, TGF-beta3, epithelial-mesenchymal transition, chemical carcinogenesis, transgenic mice, epithelial cell plasticity
- MeSH terms
- Animals, Carcinoma, Carcinoma, Squamous Cell, Cells, Cultured, Female, Immunologic Techniques, Keratins, Mice, Transgenic, Papilloma, Skin Neoplasms, Integrins, Transforming Growth Factor beta, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
