Akhurst, Rosemary J.

TGF-β Signaling in Tumor Suppression and Cancer Progression

Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics

TGF-β signaling in diseasesMechanisms of cancer metastasis

Cited by 2,275

Targeting the TGFβ signalling pathway in disease

Akhurst, R. J., & Hata, A. (2012) · Nature Reviews Drug Discovery

TGF-β signaling in diseasesConnective tissue disorders research

Cited by 1,466

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., & Akhurst, R. J. (1995) · Development

TGF-β signaling in diseasesDevelopmental Biology and Gene Regulation

Cited by 1,029

TGFβ biology in cancer progression and immunotherapy

Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology

TGF-β signaling in diseasesCancer Immunotherapy and Biomarkers

Cited by 944

TGF- β signaling in cancer – a double-edged sword

Akhurst, R. J., & Derynck, R. (2001) · Trends in Cell Biology

TGF-β signaling in diseasesMechanisms of cancer metastasis

Cited by 756

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

Cui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A., & Akhurst, R. J. (1996) · Cell

TGF-β signaling in diseasesCancer Cells and Metastasis

Cited by 628

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

Dodagatta-Marri, E., Meyer, D. S., Reeves, M. Q., Paniagua, R., To, M. D., Binnewies, M., Broz, M. L., Mori, H., Wu, D., Adoumie, M., et al. (2019) · Journal for ImmunoTherapy of Cancer

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 177

Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice

Bonyadi, M., Rusholme, S. A. B., Cousins, F. M., Su, H. C., Biron, C. A., Farrall, M., & Akhurst, R. J. (1997) · Nature Genetics

TGF-β signaling in diseasesGenetic Associations and Epidemiology

Cited by 166

Outgrowth of Drug-Resistant Carcinomas Expressing Markers of Tumor Aggression after Long-term TβRI/II Kinase Inhibition with LY2109761

Connolly, E. C., Saunier, E. F., Quigley, D., Luu, M. T., De Sapio, A., Hann, B., Yingling, J. M., & Akhurst, R. J. (2011) · Cancer Research

TGF-β signaling in diseasesCancer Cells and Metastasis

Cited by 82

Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy

Dodagatta-Marri, E., Ma, H.-Y., Liang, B., Li, J., Meyer, D. S., Sun, K.-H., Ren, X., Zivak, B., Rosenblum, M. D., Headley, M. B., et al. (2020) · Cell Reports

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 70

Matters of context guide future research in TGFβ superfamily signaling

Akhurst, R. J., & Padgett, R. W. (2015) · Science Signaling

TGF-β signaling in diseasesDevelopmental Biology and Gene Regulation

Cited by 52

Genetic variants of Adam17 differentially regulate TGFβ signaling to modify vascular pathology in mice and humans

Kawasaki, K., Freimuth, J., Meyer, D. S., Lee, M. M., Tochimoto-Okamoto, A., Benzinou, M., Clermont, F. F., Wu, G., Roy, R., Letteboer, T. G. W., et al. (2014) · Proceedings of the National Academy of Sciences

TGF-β signaling in diseasesVascular Anomalies and Treatments

Cited by 47