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The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

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Lemaitre, Bruno, Nicolas, Emmanuelle, Michaut, Lydia, Reichhart, Jean-Marc, Hoffmann, Jules A·1996·Cell

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Research works printed but not linked: 54

  1. Anderson, 1984, Information for the dorso-ventral pattern of the Drosophila embryo is stored as maternal mRNA, Nature, 311, 223, 10.1038/311223a0 · DOI · Paper page
  2. Anderson, K.V., and Nüsslein-Volhard, C. (1986). Dorsal-group genes of Drosophila. In Gametogenesis and the Early Embryo, J. Gall, ed. (New York: Alan R. Liss), pp. 177–194.
  3. Asling, 1995, Identification of early genes in the Drosophila immune response by PCR-based differential display, Insect Biochem. Mol. Biol., 25, 511, 10.1016/0965-1748(94)00091-C · DOI
  4. Beg, 1995, Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in IκBα-deficient mice, Genes Dev., 9, 2736, 10.1101/gad.9.22.2736 · DOI · Paper page
  5. Boman, 1995, Peptide antibiotics and their role in innate immunity, Annu. Rev. Immunol., 13, 61, 10.1146/annurev.iy.13.040195.000425 · DOI
  6. Broekaert, 1995, Plant defensins, Plant Physiol., 108, 1353, 10.1104/pp.108.4.1353 · DOI · Paper page
  7. Bulet, 1993, A novel inducible antibacterial peptide of Drosophila carries an O-glycosylated substitution, J. Biol. Chem., 268, 14893, 10.1016/S0021-9258(18)82417-6 · DOI · Paper page
  8. Cao, 1996, IRAK, Science, 271, 1128, 10.1126/science.271.5252.1128 · DOI · Paper page
  9. Chasan, 1989, Activation of easter, an apparent serine protease, in organizing the dorsal–ventral axis of the Drosophila embryo, Cell, 56, 391, 10.1016/0092-8674(89)90242-0 · DOI
  10. DeLotto, 1986, A gene required for the specification of the dorsal-ventral pattern in Drosophila appears to encode a serine protease, Nature, 323, 688, 10.1038/323688a0 · DOI
  11. Dimarcq, 1994, Characterization and transcriptional profile of a Drosophila gene encoding an insect defensin, Eur. J. Biochem., 221, 201, 10.1111/j.1432-1033.1994.tb18730.x · DOI
  12. Dinesh-Kumar, 1995, Transposon tagging of tobacco mosaic virus resistance gene N, Proc. Natl. Acad. Sci. USA, 92, 4175, 10.1073/pnas.92.10.4175 · DOI
  13. Engström, 1993, κB-like motifs regulate the induction of immune genes in Drosophila, J. Mol. Biol., 232, 327, 10.1006/jmbi.1993.1392 · DOI
  14. Fehlbaum, 1994, Insect immunity, J. Biol. Chem., 269, 33159, 10.1016/S0021-9258(20)30111-3 · DOI · Paper page
  15. Flyg, 1988, Drosophila genes cut and miniature are associated with the susceptibility to infection by Serratia marcescens, Genet. Res., 52, 51, 10.1017/S0016672300027300 · DOI
  16. Gay, 1991, Drosophila Toll and IL-1 receptor, Nature, 351, 355, 10.1038/351355b0 · DOI · Paper page
  17. Geisler, 1992, cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates, Cell, 71, 613, 10.1016/0092-8674(92)90595-4 · DOI
  18. Gertulla, 1988, Zygotic expression and activity of the Drosophila Toll gene, a gene required maternally for embryonic dorsal-ventral pattern formation, Genetics, 119, 123, 10.1093/genetics/119.1.123 · DOI
  19. Gross, 1996, Drosophila immunity, Nucl. Acids Res., 24, 1238, 10.1093/nar/24.7.1238 · DOI
  20. Hashimoto, 1988, The Toll gene of Drosophila, required for dorso–ventral embryonic polarity, appears to encode a transmembrane protein, Cell, 52, 269, 10.1016/0092-8674(88)90516-8 · DOI · Paper page
  21. Hecht, 1992, Extracellular proteases and embryonic pattern formation, Trends Cell Biol., 2, 197, 10.1016/0962-8924(92)90246-J · DOI
  22. Hecht, 1993, Genetic characterization of tube and pelle genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo, Genetics, 135, 405, 10.1093/genetics/135.2.405 · DOI · Paper page
  23. Heguy, 1992, Amino acids conserved in interleukin-1 receptor (IL-1R) and the Drosophila Toll protein are essential for IL-1R signal transduction, J. Biol. Chem., 267, 2604, 10.1016/S0021-9258(18)45924-8 · DOI
  24. Hetru, C., Bulet, P., Cociancich, S., Dimarq, J.L., Hoffmann, D., and Hoffmann, J.A. (1994). Antibacterial peptides/polypeptides in the insect host defense. In Perspective in Immunity: The Insect Host Defense, J.A. Hoffmann, C. Janeway, and S. Natori, eds. (Austin, Texas: R.G. Landes Company), pp. 167–181.
  25. Hoffmann, 1995, Innate immunity of insects, Curr. Opin. Immunol., 7, 4, 10.1016/0952-7915(95)80022-0 · DOI · Paper page
  26. Hultmark, 1993, Immune reactions in Drosophila and other insects, Trends Genet., 9, 178, 10.1016/0168-9525(93)90165-E · DOI · Paper page
  27. Ip, 1993, Dif, a dorsal-related gene that mediates an immune response in Drosophila, Cell, 75, 753, 10.1016/0092-8674(93)90495-C · DOI · Paper page
  28. Iwanaga, 1993, The limulus clotting reaction, Curr. Opin. Immunol., 5, 74, 10.1016/0952-7915(93)90084-6 · DOI
  29. Jin, 1990, Dominant and recessive alleles of the Drosophila easter gene are point mutations at conserved sites in the serine protease catalytic domain, Cell, 60, 873, 10.1016/0092-8674(90)90100-S · DOI
  30. Kappler, 1993, Insect immunity, EMBO J., 12, 1561, 10.1002/j.1460-2075.1993.tb05800.x · DOI
  31. Kidd, 1992, Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins, Cell, 71, 623, 10.1016/0092-8674(92)90596-5 · DOI
  32. Kylsten, 1990, The cecropin locus in Drosophila, EMBO J., 9, 217, 10.1002/j.1460-2075.1990.tb08098.x · DOI · Paper page
  33. Lemaitre, 1995, A novel mutation, immune deficiency, defines two distinct control pathways in the Drosophila host defense, Proc. Natl. Acad. Sci. USA, 92, 9465, 10.1073/pnas.92.21.9465 · DOI · Paper page
  34. Lemaitre, 1995, Functional analysis and regulation of nuclear import of dorsal during the immune response of Drosphila, EMBO J., 14, 536, 10.1002/j.1460-2075.1995.tb07029.x · DOI · Paper page
  35. Letsou, 1991, Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity, Proc. Natl. Acad. Sci. USA, 88, 810, 10.1073/pnas.88.3.810 · DOI
  36. Morisato, 1994, The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsoventral pattern of the Drosophila embryo, Cell, 76, 677, 10.1016/0092-8674(94)90507-X · DOI · Paper page
  37. Morisato, 1995, Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo, Annu. Rev. Genet., 29, 371, 10.1146/annurev.genet.29.1.371 · DOI
  38. O'Connell, 1984, Sequence, structure and codon preference of the Drosophila ribosomal protein 49 gene, Nucl. Acids Res., 12, 5495, 10.1093/nar/12.13.5495 · DOI · Paper page
  39. Petersen, 1995, The dorsal-related immunity factor, Dif is a sequence-specific trans-activator of Drosophila Cecropin gene expression, EMBO J., 14, 3146, 10.1002/j.1460-2075.1995.tb07317.x · DOI
  40. Reichhart, 1993, Expression and nuclear translocation of the rel/NF-κB-related morphogen dorsal during the immune response of Drosophila, CR Acad. Sci. (Paris), 316, 1207
  41. Rosetto, 1995, Signals from the IL-1 receptor homolog, Toll, can activate an immune response in a Drosophila hemocyte cell line, Biochem. Biophys. Res. Commun., 209, 111, 10.1006/bbrc.1995.1477 · DOI
  42. Roth, 1991, cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos, Development, 112, 371, 10.1242/dev.112.2.371 · DOI
  43. Schneider, 1994, A processed form of spätzle protein defines dorso-ventral polarity in the Drosophila embryo, Development, 120, 1243, 10.1242/dev.120.5.1243 · DOI
  44. Shelton, 1993, pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo, Cell, 72, 515, 10.1016/0092-8674(93)90071-W · DOI
  45. Siebenlist, 1994, Structure, regulation and function of NF-κB, Annu. Rev. Cell Biol., 10, 405, 10.1146/annurev.cb.10.110194.002201 · DOI · Paper page
  46. Smith, 1994, Mutational analysis of the Drosophila snake protease, Genetics, 136, 1355, 10.1093/genetics/136.4.1355 · DOI
  47. Steward, 1987, Dorsal, an embryonic polarity gene in Drosophila is homologous to the vertebrate proto-oncogene, c-rel, Science, 238, 692, 10.1126/science.3118464 · DOI · Paper page
  48. Sun, 1991, Structure and expression of the attacin genes in Hyalophora cecropia, Eur. J. Biochem., 196, 247, 10.1111/j.1432-1033.1991.tb15811.x · DOI
  49. Tatei, 1995, Specificity of Rel-inhibitor interactions in Drosophila embryos, Mol. Cell. Biol., 15, 3627, 10.1128/MCB.15.7.3627 · DOI
  50. Tryselius, 1992, CecC, a cecropin gene expressed during metamorphosis in Drosophila pupae, Eur. J. Biochem., 204, 395, 10.1111/j.1432-1033.1992.tb16648.x · DOI
  51. Vey A., and Götz P. (1986). Antifungal cellular defense mechanisms in insects. In Hemocytic and Humoral Immunity in Athropods, A.P. Gupta, ed. (New York: John Wiley & Sons, Inc.), pp. 89–115.
  52. Wasserman, 1993, A conserved signal transduction pathway regulating the activity of the Rel-like proteins dorsal and NF-κB, Mol. Biol. Cell, 4, 767, 10.1091/mbc.4.8.767 · DOI
  53. Whitham, 1994, The product of the tobacco mosaic virus resistance gene N, Cell, 78, 1101, 10.1016/0092-8674(94)90283-6 · DOI · Paper page
  54. Wicker, 1990, Insect immunity, J. Biol. Chem., 265, 22493, 10.1016/S0021-9258(18)45732-8 · DOI

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Metadata

Authors
Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.-M., & Hoffmann, J. A.
Venue
Cell
Publisher
Elsevier BV
Published
1996-09
Volume
86
Issue
6
Pages
973-983
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2137590150
Cited by
4,043
References
1
FWCI
20.30
Type
journal article
Language
en
Open access
bronze
Licence

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