The DOI matches its Crossref record.
Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel
Abstract
The Drosophila gene, dorsal , is a maternal effect locus that is essential for the establishment of dorsal-ventral polarity in the developing embryo. The dorsal protein was predicted from the complementary DNA sequence; it is almost 50 percent identical, over an extensive region, to the protein encoded by the avian oncogene v- rel , its cellular homolog, c- rel , and a human c- rel fragment. The oncogene v- rel is highly oncogenic in avian lymphoid, spleen, and bone marrow cells.
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Citations
Cited by
Toll-like Receptors and the Control of Immunity
Fitzgerald, K. A., & Kagan, J. C. (2020) · Cell · doi:10.1016/j.cell.2020.02.041 · Cited by 2,168
The history of toll-like receptors - redefining innate immunity
O'Neill, L. A. J., Golenbock, D., & Bowie, A. G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3446 · Cited by 1,765
A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway
Belvin, M. P., & Anderson, K. V. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.393 · Cited by 836
Markstein, M., Markstein, P., Markstein, V., & Levine, M. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012591199 · Cited by 375
The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos.
Jiang, J., Kosman, D., Ip, Y. T., & Levine, M. (1991) · Genes & Development · doi:10.1101/gad.5.10.1881 · Cited by 365
Metadata
- Authors
- Steward, R.
- Venue
- Science
- Published
- 1987-10-30
- Volume
- 238
- Issue
- 4827
- Pages
- 692-694
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2076854746
- Cited by
- 484
- References
- 0
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel. https://app.cochat.ai/papers/10.1126/science.3118464
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- Steward, R. (1987). Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel. Science. https://doi.org/10.1126/science.3118464
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