The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Thermally Regulated Translational Control of FRQ Mediates Aspects of Temperature Responses in the Neurospora Circadian Clock
Open accessAbstract
Two forms of FRQ, a central component of the Neurospora circadian clock, arise through alternative in-frame initiation of translation. Either form alone suffices for a functional clock at some temperatures, but both are always necessary for robust rhythmicity. Temperature regulates the ratio of FRQ forms by favoring different initiation codons at different temperatures; when either initiation codon is eliminated, the temperature range permissive for rhythmicity is demonstrably reduced. This temperature-influenced choice of translation-initiation site represents a novel adaptive mechanism that extends the physiological temperature range over which clocks function. Additionally, a temperature-dependent threshold level of FRQ is required to establish the feedback loop comprising the oscillator. These data may explain how temperature limits permissive for rhythmicity are established, thus providing a molecular understanding for a basic characteristic of circadian clocks.
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Self-citation
Cited by
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Metadata
- Authors
- Liu, Y., Garceau, N. Y., Loros, J. J., & Dunlap, J. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-05
- Volume
- 89
- Issue
- 3
- Pages
- 477-486
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2056296605
- Cited by
- 255
- References
- 40
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Liu, Y., Garceau, N. Y., Loros, J. J., & Dunlap, J. C. (1997). Thermally Regulated Translational Control of FRQ Mediates Aspects of Temperature Responses in the Neurospora Circadian Clock. Cell. https://doi.org/10.1016/s0092-8674(00)80228-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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