Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators
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Time and Temperature: Daily cycles in environmental temperature are an important cue for many organisms to synchronize their endogenous circadian clock. However, mammals do not respond to this cue. Studying mouse tissue, Buhr et al. (p. 379 ; see the Perspective by Edery ) find that this resistance to temperature is a feature specific to the suprachiasmatic nucleus (SCN), a region of the mammalian brain that functions as the body's master clock. In contrast, the clocks in peripheral tissues (for example, lung, liver) are fully capable of resetting in response to temperature changes and do so by a mechanism involving the heat shock pathway. The SCN drives daily rhythms in body temperature, and SCN-driven changes in temperature may synchronize the body's peripheral clocks. Without its intrinsic resistance to temperature, the SCN could be subject to disruptive feedback effects.
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The SCN becomes sensitive to ambient temperature cycles only if communication between its neurons is restricted, as in early development or with tetrodotoxin application.
“The SCN itself becomes sensitive to ambient temperature cycles only if communication between its neurons is restricted, as is the case in early development [39] or can be accomplished with application of tetrodotoxin [9].”
From Sleep, vigilance, and thermosensitivity (2012) · cites this paper as [9]
Peripheral oscillators, including those in the brain such as the cerebral cortex, can be entrained by ambient temperature cycles.
“evidence has accumulated over the last decade to indicate that peripheral oscillators, including those in the brain (e.g., cerebral cortex), can be entrained by ambient temperature cycles [8, 9, 28].”
From Sleep, vigilance, and thermosensitivity (2012) · cites this paper as [9]
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The Liver in the Eyes of a Chronobiologist
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The circadian clock control of adipose tissue physiology and metabolism
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Warming Up Your Tick-Tock: Temperature-Dependent Regulation of Circadian Clocks
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Temperatures to Communicate By
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Anatomy of the Mammalian Circadian System
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Behavioral adaptation to warm conditions via Lim1-mediated acceleration of neuronal clocks.
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- Authors
- Buhr, E. D., Yoo, S.-H., & Takahashi, J. S.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Takahashi, Joseph S.
- Venue
- Science
- Published
- 2010-10-15
- Volume
- 330
- Issue
- 6002
- Pages
- 379-385
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3625727
- OpenAlex
- W1984912966
- Cited by
- 917
- References
- 50
- Citations by year
- 2026: 34 · 2025: 59 · 2024: 61 · 2023: 54 · 2022: 65 · 2021: 71 · 2020: 57 · 2019: 54 · 2018: 49 · 2017: 59 · 2016: 68 · 2015: 62 · 2014: 52 · 2013: 74 · 2012: 47
- FWCI
- 24.42
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5p50mh074924-05, 5t32ag020418-08)
- National Institute on Aging (T32 AG 20418, T32-AG020418)
- National Institute of Mental Health (P50 MH-074924)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Computer Science › Computer Networks and Communications › Nonlinear Dynamics and Pattern Formation
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- temperature entrainment, circadian clock, suprachiasmatic nucleus, temperature compensation, body temperature rhythm, homeothermy, circadian synchronization, network interaction
- MeSH terms
- Heat Shock Transcription Factors, Animals, Arginine Vasopressin, Benzhydryl Compounds, Biological Clocks, Body Temperature, Body Temperature Regulation, Cell Communication, Circadian Rhythm, Cues, DNA-Binding Proteins, Lung, Pituitary Gland, Pyrrolidinones, Suprachiasmatic Nucleus, Temperature, Transcription Factors, Transcription, Genetic, Vasoactive Intestinal Peptide, Signal Transduction, Heat-Shock Response, Calcium Channels, L-Type, Tissue Culture Techniques, Mice
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