The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Photoreceptor Cell Differentiation Requires Regulated Proteolysis of the Transcriptional Repressor Tramtrack
Open accessAbstract
The transcription repressor Tramtrack (TTK) is found in cone cells but not photoreceptor cells of the Drosophila eye. We show that down-regulation of TTK expression occurs in photoreceptor cells and is required for their fate determination. Down-regulation requires the presence of Phyllopod (PHYL), which is induced by the RAS pathway, and Seven In Absentia (SINA). Loss of either gene causes accumulation of TTK in photoreceptor cells, and TTK does not accumulate in cone cells if both PHYL and SINA are present. We report that SINA and PHYL promote ubiquitination and rapid degradation of TTK by the proteasome pathway in cell culture, and both SINA and PHYL bind to the N-terminal domain of TTK. These results argue that photoreceptor differentiation is regulated by the RAS pathway through targeted proteolysis of the TTK repressor.
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Brunner, D., Dücker, K., Oellers, N., Hafen, E., Scholzi, H., & Klambt, C. (1994) · Nature · doi:10.1038/370386a0 · Cited by 366
Dorn, R., Krauss, V, Reuter, G., & Saumweber, H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11376 · Cited by 178
Cited by
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Giot, L., Bader, J. S., Brouwer, C., Chaudhuri, A., Kuang, B., Li, Y., Hao, Y. L., Ooi, C. E., Godwin, B., Vitols, E., et al. (2003) · Science · doi:10.1126/science.1090289 · Cited by 1,863
Self-citationMdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53
Fang, S., Jensen, J. P., Ludwig, R. L., Vousden, K. H., & Weissman, A. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8945 · Cited by 1,044
A MicroRNA Imparts Robustness against Environmental Fluctuation during Development
Li, X., Cassidy, J. J., Reinke, C. A., Fischboeck, S., & Carthew, R. W. (2009) · Cell · doi:10.1016/j.cell.2009.01.058 · Cited by 431
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Kumar, J. P. (2012) · Developmental Dynamics · doi:10.1002/dvdy.23707 · Cited by 170
Metadata
- Authors
- Li, S., Li, Y., Carthew, R. W., & Lai, Z.-C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 90
- Issue
- 3
- Pages
- 469-478
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2089559354
- Cited by
- 218
- References
- 2
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, S., Li, Y., Carthew, R. W., & Lai, Z.-C. (1997). Photoreceptor Cell Differentiation Requires Regulated Proteolysis of the Transcriptional Repressor Tramtrack. Cell. https://doi.org/10.1016/s0092-8674(00)80507-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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