The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
The Drosophila Gene brinker Reveals a Novel Mechanism of Dpp Target Gene Regulation
Open accessAbstract
decapentaplegic (dpp), a Drosophila member of the TGFbeta family of secreted molecules, functions as a long-range morphogen in patterning of the embryo and the adult appendages. Dpp signals via the SMAD proteins Mad and Medea. Here we show that in the absence of brinker (brk), Mad is not required for the activation of Dpp target genes that depend on low levels of Dpp. brk encodes a novel protein with features of a transcriptional repressor. brk itself is negatively regulated by Dpp. Dpp signaling might relieve brk's repression of low-level target genes either by transcriptional repression of brk or by antagonizing a repressor function of brk at the target gene promoters.
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Cites
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
Brand, A. H., & Perrimon, N. (1993) · Development · doi:10.1242/dev.118.2.401 · Cited by 9,612
Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,556
TGF-β signalling from cell membrane to nucleus through SMAD proteins
Heldin, C.-H., Miyazono, K., & ten Dijke, P. (1997) · Nature · doi:10.1038/37284 · Cited by 3,696
Tautz, D., & Pfeifle, C. (1989) · Chromosoma · doi:10.1007/bf00291041 · Cited by 2,523
A short amino acid sequence able to specify nuclear location
Kalderon, D., Roberts, B. L., Richardson, W. D., & Smith, A. E. (1984) · Cell · doi:10.1016/0092-8674(84)90457-4 · Cited by 2,507
Analysis of genetic mosaics in developing and adult Drosophila tissues
Xu, T., & Rubin, G. M. (1993) · Development · doi:10.1242/dev.117.4.1223 · Cited by 2,041
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
Nakao, A., Afrakhte, M., Morn, A., Nakayama, T., Christian, J. L., Heuchel, R., Itoh, S., Kawabata, M., Heldin, N.-E., Heldin, C.-H., et al. (1997) · Nature · doi:10.1038/39369 · Cited by 1,809
Dennler, S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3091 · Cited by 1,793
Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y.-Y., Grinnell, B. W., Richardson, M. A., Topper, J. N., Gimbrone, M. A., Wrana, J. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80303-7 · Cited by 1,334
Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators
Zawel, L., Le Dai, J., Buckhaults, P., Zhou, S., Kinzler, K. W., Vogelstein, B., & Kern, S. E. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80061-1 · Cited by 939
Cited by
A Smad Transcriptional Corepressor
Wotton, D., Lo, R. S., Lee, S., & Massagué, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80712-6 · Cited by 561
Dpp Gradient Formation in the Drosophila Wing Imaginal Disc
Teleman, A. A., & Cohen, S. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00199-9 · Cited by 454
Moreno, E., Basler, K., & Morata, G. (2002) · Nature · doi:10.1038/416755a · Cited by 451
Chen, D., & McKearin, D. M. (2003) · Development · doi:10.1242/dev.00325 · Cited by 447
Self-Enhanced Ligand Degradation Underlies Robustness of Morphogen Gradients
Eldar, A., Rosin, D., Shilo, B.-Z., & Barkai, N. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00292-2 · Cited by 289
Metadata
- Authors
- Jaźwińska, A., Kirov, N., Wieschaus, E., Roth, S., & Rushlow, C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-02
- Volume
- 96
- Issue
- 4
- Pages
- 563-573
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2003038417
- Cited by
- 269
- References
- 63
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Jaźwińska, A., Kirov, N., Wieschaus, E., Roth, S., & Rushlow, C. (1999). The Drosophila Gene brinker Reveals a Novel Mechanism of Dpp Target Gene Regulation. Cell. https://doi.org/10.1016/s0092-8674(00)80660-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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