The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
A Sonic Hedgehog–Independent, Retinoid-Activated Pathway of Neurogenesis in the Ventral Spinal Cord
Open accessAbstract
Sonic hedgehog (Shh) is thought to control the generation of motor neurons and interneurons in the ventral CNS. We show here that a Shh-independent pathway of interneuron generation also operates in the ventral spinal cord. Evidence for this parallel pathway emerged from an analysis of the induction of ventral progenitors that express the Dbx homeodomain proteins and of Evx1/2 (V0) and En1 (V1) neurons. Shh signaling is sufficient to induce Dbx cells and V0 and V1 neurons but is not required for their generation in vitro or in vivo. Retinoids appear to mediate this parallel pathway. These findings reveal an unanticipated Shh-independent signaling pathway that controls progenitor cell identity and interneuron diversity in the ventral spinal cord.
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A series of normal stages in the development of the chick embryo
Hamburger, V., & Hamilton, H. L. (1951) · Journal of Morphology · doi:10.1002/jmor.1050880104 · Cited by 12,234
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062
Self-citationSonic hedgehog mediates the polarizing activity of the ZPA
Riddle, R. D., Johnson, R. L., Laufer, E., & Tabin, C. (1993) · Cell · doi:10.1016/0092-8674(93)90626-2 · Cited by 2,307
Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154
Erratum: Mouse Small eye results from mutation in a paired-like homebox-containing gene
Hill, R. E., Favor, J., Hogan, B. L. M., Ton, C. C. T., Saunders, G. F., Hanson, I. M., Prosser, J., Jordan, T., Hastie, N. D., & van Heyningen, V. (1992) · Nature · doi:10.1038/355750a0 · Cited by 1,270
Mouse Small eye results from mutations in a paired-like homeobox-containing gene
Hill, R. E., Favor, J., Hogan, B. L. M., Ton, C. C. T., Saunders, G. F., Hanson, I. M., Prosser, J., Jordan, T., Hastie, N. D., & Heyningen, V. V. (1991) · Nature · doi:10.1038/354522a0 · Cited by 1,158
Schaeren-Wiemers, N., & Gerfin-Moser, A. (1993) · Histochemistry · doi:10.1007/bf00267823 · Cited by 1,157
Patterning the Vertebrate Neuraxis
Lumsden, A., & Krumlauf, R. (1996) · Science · doi:10.1126/science.274.5290.1109 · Cited by 1,146
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
Niederreither, K., Subbarayan, V., Dollé, P., & Chambon, P. (1999) · Nature Genetics · doi:10.1038/7788 · Cited by 1,077
Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
Liem, K. F., Tremml, G., Roelink, H., & Jessell, T. M. (1995) · Cell · doi:10.1016/0092-8674(95)90276-7 · Cited by 1,071
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Cited by
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Self-citationHedgehog: functions and mechanisms
Varjosalo, M., & Taipale, J. (2008) · Genes & Development · doi:10.1101/gad.1693608 · Cited by 1,217
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Novitch, B. G., Chen, A. I., & Jessell, T. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00407-x · Cited by 615
Self-citationLippmann, E. S., Al-Ahmad, A., Azarin, S. M., Palecek, S. P., & Shusta, E. V. (2014) · Scientific Reports · doi:10.1038/srep04160 · Cited by 508
Metadata
- Authors
- Pierani, A., Brenner-Morton, S., Chiang, C., & Jessell, T. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-06
- Volume
- 97
- Issue
- 7
- Pages
- 903-915
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2151892983
- Cited by
- 363
- References
- 51
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pierani, A., Brenner-Morton, S., Chiang, C., & Jessell, T. M. (1999). A Sonic Hedgehog–Independent, Retinoid-Activated Pathway of Neurogenesis in the Ventral Spinal Cord. Cell. https://doi.org/10.1016/s0092-8674(00)80802-8
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