The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cell Type–Specific Chromatin Structure Determines the Targeting of V(D)J Recombinase Activity In Vitro
Open accessAbstract
A common V(D)J recombinase that recognizes a conserved recombination signal sequence (RSS) mediates the assembly of immunoglobulin (Ig) and T cell receptor (TCR) genes in B and T cell precursors. The rearrangement of particular Ig and TCR gene segments, however, is tightly regulated with respect to cell lineage and developmental stage. Using an in vitro system, we analyzed recombinase cleavage of RSSs flanking Ig and TCR gene segments in nuclei. We found that both the lineage-specificity and temporal ordering of gene rearrangement is reflected in the accessibility of RSSs within chromatin to in vitro cleavage.
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Citations
Cites
Somatic generation of antibody diversity
Tonegawa, S. (1983) · Nature · doi:10.1038/302575a0 · Cited by 4,005
Ordered rearrangement of immunoglobulin heavy chain variable region segments
Alt, F. W., Yancopoulos, G. D., Blackwell, T. K., Wood, C., Thomas, E., Boss, M., Coffman, R., Rosenberg, N., Tonegawa, S., & Baltimore, D. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb01955.x · Cited by 733
Cited by
Recombination centres and the orchestration of V(D)J recombination
Schatz, D. G., & Ji, Y. (2011) · Nature Reviews Immunology · doi:10.1038/nri2941 · Cited by 658
MECHANISM AND CONTROL OF V(D)J RECOMBINATION AT THE IMMUNOGLOBULIN HEAVY CHAIN LOCUS
Jung, D., Giallourakis, C., Mostoslavsky, R., & Alt, F. W. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115830 · Cited by 578
Pax5 induces V -to- DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene
Fuxa, M., Skok, J., Souabni, A., Salvagiotto, G., Roldan, E., & Busslinger, M. (2004) · Genes & Development · doi:10.1101/gad.291504 · Cited by 414
CTCF and Cohesin: Linking Gene Regulatory Elements with Their Targets
Merkenschlager, M., & Odom, D. T. (2013) · Cell · doi:10.1016/j.cell.2013.02.029 · Cited by 345
A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination
McMurry, M. T., & Krangel, M. S. (2000) · Science · doi:10.1126/science.287.5452.495 · Cited by 288
Metadata
- Authors
- Stanhope-Baker, P., Hudson, K. M., Shaffer, A. L., Constantinescu, A., & Schlissel, M. S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-06
- Volume
- 85
- Issue
- 6
- Pages
- 887-897
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2099719096
- Cited by
- 299
- References
- 2
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Stanhope-Baker, P., Hudson, K. M., Shaffer, A. L., Constantinescu, A., & Schlissel, M. S. (1996). Cell Type–Specific Chromatin Structure Determines the Targeting of V(D)J Recombinase Activity In Vitro. Cell. https://doi.org/10.1016/s0092-8674(00)81272-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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