The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination
Abstract
V(D)J recombination is developmentally regulated in vivo by enhancer-dependent changes in the accessibility of chromosomal recombination signal sequences to the recombinase, but the molecular nature of these changes is unknown. Here histone H3 acetylation was measured along versions of a transgenic V(D)J recombination reporter and the endogenous T cell receptor α/δ locus. Enhancer activity was shown to impart long-range, developmentally regulated changes in H3 acetylation, and H3 acetylation status was tightly linked to V(D)J recombination. H3 hyperacetylation is proposed as a molecular mechanism coupling enhancer activity to accessibility for V(D)J recombination.
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Cites
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
Shinkai, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90029-c · Cited by 2,150
Histone acetylation and transcriptional regulatory mechanisms
Struhl, K. (1998) · Genes & Development · doi:10.1101/gad.12.5.599 · Cited by 1,815
ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION
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A positive role for histone acetylation in transcription factor access to nucleosomal DNA
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Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes
Shinkai, Y., Koyasu, S., Nakayama, K.-I., Murphy, K. M., Loh, D. Y., Reinherz, E. L., & Alt, F. W. (1993) · Science · doi:10.1126/science.8430336 · Cited by 401
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ACCESSIBILITY CONTROL OF ANTIGEN-RECEPTOR VARIABLE-REGION GENE ASSEMBLY: Role of cis-Acting Elements
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The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
Landry, J., Sutton, A., Tafrov, S. T., Heller, R. C., Stebbins, J., Pillus, L., & Sternglanz, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.110148297 · Cited by 970
The many faces of histone lysine methylation
Lachner, M., & Jenuwein, T. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00335-6 · Cited by 819
Replication fork stalling at natural impediments
Mirkin, E. V., & Mirkin, S. M. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00030-06 · Cited by 482
Epigenetics—An Epicenter of Gene Regulation: Histones and Histone‐Modifying Enzymes
Biel, M., Wascholowski, V., & Giannis, A. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200461346 · Cited by 316
Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R., & Desiderio, S. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.005 · Cited by 271
Metadata
- Authors
- McMurry, M. T., & Krangel, M. S.
- Venue
- Science
- Published
- 2000-01-21
- Volume
- 287
- Issue
- 5452
- Pages
- 495-498
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089836142
- Cited by
- 288
- References
- 31
- FWCI
- 13.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- McMurry, M. T., & Krangel, M. S. (2000). A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination. Science. https://doi.org/10.1126/science.287.5452.495
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
