The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Mesenchymal to Epithelial Conversion in Rat Metanephros Is Induced by LIF
Open accessAbstract
Inductive signals cause conversion of mesenchyme into epithelia during the formation of many organs. Yet a century of study has not revealed the inducing molecules. Using a standard model of induction, we found that ureteric bud cells secrete factors that convert kidney mesenchyme to epithelia that, remarkably, then form nephrons. Purification and sequencing of one such factor identified it as leukemia inhibitory factor (LIF). LIF acted on epithelial precursors that we identified by the expression of Pax2 and Wnt4. Other IL-6 type cytokines acted like LIF, and deletion of their shared receptor reduced nephron development. In situ, the ureteric bud expressed LIF, and metanephric mesenchyme expressed its receptors. The data suggest that IL-6 cytokines are candidate regulators of mesenchymal to epithelial conversion during kidney development.
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An Iron Delivery Pathway Mediated by a Lipocalin
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Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development
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Metadata
- Authors
- Barasch, J., Yang, J., Ware, C. B., Taga, T., Yoshida, K., Erdjument-Bromage, H., Tempst, P., Parravicini, E., Malach, S., Aranoff, T., & Oliver, J. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 99
- Issue
- 4
- Pages
- 377-386
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1965785388
- Cited by
- 272
- References
- 62
- FWCI
- 7.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Mesenchymal to Epithelial Conversion in Rat Metanephros Is Induced by LIF. https://app.cochat.ai/papers/10.1016/s0092-8674(00)81524-x
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- Barasch, J., Yang, J., Ware, C. B., Taga, T., Yoshida, K., Erdjument-Bromage, H., Tempst, P., Parravicini, E., Malach, S., Aranoff, T., & Oliver, J. A. (1999). Mesenchymal to Epithelial Conversion in Rat Metanephros Is Induced by LIF. Cell. https://doi.org/10.1016/s0092-8674(00)81524-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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