DNA Transposition by the RAG1 and RAG2 Proteins

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

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The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining

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Sequences at the somatic recombination sites of immunoglobulin light-chain genes

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Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

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HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer

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The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative Analyses

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TRANSPOSITIONAL RECOMBINATION: Mechanistic Insights from Studies of Mu and Other Elements

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Reversal of Integration and DNA Splicing Mediated by Integrase of Human Immunodeficiency Virus

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Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease

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RAG1 and RAG2 Form a Stable Postcleavage Synaptic Complex with DNA Containing Signal Ends in V(D)J Recombination

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TARGET SITE SELECTION IN TRANSPOSITION

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The RAG1 and RAG2 Proteins Establish the 12/23 Rule in V(D)J Recombination

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Similarities Between Initiation of V(D)J Recombination and Retroviral Integration

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Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript.

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Disruption of the Human SCL Locus by "Illegitimate" V-(D)-J Recombinase Activity

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New insights into V(D)J recombination and its role in the evolution of the immune system

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Chromosomal Translocations In Lymphoid Malignancies Reveal Novel Proto-Oncogenes

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Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners.

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Assembly of a 12/23 Paired Signal Complex: A Critical Control Point in V(D)J Recombination

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A Stable RAG1–RAG2–DNA Complex That Is Active in V(D)J Cleavage

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Recent Advances in Understanding V(D)J Recombination

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Inversion of the phosphate chirality at the target site of Mu DNA strand transfer: Evidence for a one-step transesterification mechanism

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Polynucleotidyl transfer reactions in transpositional DNA recombination.

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Formation and resolution of double-strand break intermediates in V(D)J rearrangement.Preprint

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The hobo transposable element of Drosophila can be cross-mobilized in houseflies and excises like the Ac element of maize.

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Cell-free V(D)J recombination

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Chromosomal translocations in lymphoid neoplasia: a reappraisal of the recombinase model.

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V(D)J Recombination in Ku86-Deficient Mice: Distinct Effects on Coding, Signal, and Hybrid Joint Formation

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The human T cell receptor genes are targets for chromosomal abnormalities in T cell tumors

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Rejoining of DNA by the RAG1 and RAG2 Proteins

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Polynucleotidyl transfer reactions in site‐specific DNA recombination

Mizuuchi, K. (1997) · Genes to Cells · doi:10.1046/j.1365-2443.1997.970297.x · Cited by 100 · see citing works

Mechanism of V(D)J recombination

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Mu Transpositional Recombination: Donor DNA Cleavage and Strand Transfer in trans by the Mu Transposase

Savilahti, H., & Mizuuchi, K. (1996) · Cell · doi:10.1016/s0092-8674(00)81103-4 · Cited by 96 · see citing works

The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo

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RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition.Preprint

Sadofsky, M. J., Hesse, J. E., van Gent, D. C., & Gellert, M. F. (1995) · Genes & Development · doi:10.1101/gad.9.17.2193 · Cited by 69 · see citing works

Ku86 Is Not Required for Protection of Signal Ends or for Formation of Nonstandard V(D)J Recombination Products

Han, J.-O., Steen, S. B., & Roth, D. B. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.2226 · Cited by 61 · see citing works

Extensive, Nonrandom Diversity of Excision Footprints Generated by Ds -Like Transposon Ascot-1 Suggests New Parallels with V(D)J Recombination

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Structural and Functional Chimerism Results from Chromosomal Translocation in Lymphoid Tumors

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UPDATE: V(D)J Recombination and Transposition: Closer Than Expected

Craig, N. L. (1996) · Science · doi:10.1126/science.271.5255.1512 · Cited by 29 · see citing works

Innate immune recognition

Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394 · see citing works

Genetic instabilities in human cancers

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RAG1 Core and V(D)J Recombination Signal Sequences Were Derived from Transib Transposons

Kapitonov, V. V., & Jurka, J. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030181 · Cited by 521 · see citing works

Frequent chromosomal translocations induced by DNA double-strand breaks

Richardson, C., & Jasin, M. (2000) · Nature · doi:10.1038/35015097 · Cited by 517 · see citing works

Transposition of hAT elements links transposable elements and V(D)J recombination

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Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

Landree, M. A., Wibbenmeyer, J. A., & Roth, D. B. (1999) · Genes & Development · doi:10.1101/gad.13.23.3059 · Cited by 209 · see citing works

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

Kim, D. R., Dai, Y., Mundy, C. L., Yang, W., & Oettinger, M. A. (1999) · Genes & Development · doi:10.1101/gad.13.23.3070 · Cited by 199 · see citing works

Our Conflict with Transposable Elements and Its Implications for Human Disease

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The role of genes domesticated from LTR retrotransposons and retroviruses in mammals

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Definition of Minimal Domains of Interaction Within the Recombination-Activating Genes 1 and 2 Recombinase Complex

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A classification of possible routes of Darwinian evolution

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V(D)J Recombination

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Updating the definition of V(D)J recombination signal sequences with high-throughput recombination assays

Hoolehan, W., & Rodgers, K. K. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.210.supp.83.21

Molecular Mechanisms of DNA Sequence Selectivity in V(D)J Recombination

Hoolehan, W., Harris, J. C., & Rodgers, K. K. (2023) · ACS Omega · doi:10.1021/acsomega.3c05601 · Cited by 7 · see citing works

Molecular Mechanism Underlying RAG1/RAG2 Synaptic Complex Formation

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The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination

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