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The Role of Maternal VegT in Establishing the Primary Germ Layers in Xenopus Embryos
Open accessAbstract
VegT is a T-box transcription factor whose mRNA is synthesized during oogenesis and localized in the vegetal hemisphere of the egg and early embryo. We show that maternally expressed VegT controls the pattern of primary germ layer specification in Xenopus embryos. Reduction of the maternal store completely alters the fates of different regions of the blastula so that animal cell fate is changed from epidermis and nervous system to epidermis only, equatorial cell fate is changed from mesoderm to ectoderm, and vegetal cell fate is changed from endoderm to mesoderm and ectoderm. Vegetal cells lose their capacity both to form endoderm and to release mesoderm-inducing signals. These results show that a single maternally expressed gene controls the patterning of the Xenopus blastula.
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Cited by
Lécuyer, E., Yoshida, H., Parthasarathy, N., Alm, C., Babak, T., Cerovina, T., Hughes, T. R., Tomancak, P., & Krause, H. M. (2007) · Cell · doi:10.1016/j.cell.2007.08.003 · Cited by 967
TGF-β Superfamily Signaling in Embryonic Development and Homeostasis
Wu, M. Y., & Hill, C. S. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.012 · Cited by 746
Tao, Q., Yokota, C., Puck, H., Kofron, M., Birsoy, B., Yan, D., Asashima, M., Wylie, C. C., Lin, X., & Heasman, J. (2005) · Cell · doi:10.1016/j.cell.2005.01.013 · Cited by 510
Self-citationThe establishment of spemann's organizer and patterning of the vertebrate embryo
De Robertis, E. M., Larraín, J., Oelgeschläger, M., & Wessely, O. (2000) · Nature Reviews Genetics · doi:10.1038/35042039 · Cited by 429
Endodermal Nodal-related signals and mesoderm induction in Xenopus
Agius, E., Oelgeschläger, M., Wessely, O., Kemp, C., & Robertis, E. M. D. (2000) · Development · doi:10.1242/dev.127.6.1173 · Cited by 420
Metadata
- Authors
- Zhang, J., Houston, D. W., King, M. L., Payne, C., Wylie, C., & Heasman, J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-08
- Volume
- 94
- Issue
- 4
- Pages
- 515-524
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2068224181
- Cited by
- 470
- References
- 0
- FWCI
- 13.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: The Role of Maternal VegT in Establishing the Primary Germ Layers in Xenopus Embryos. https://app.cochat.ai/papers/10.1016/s0092-8674(00)81592-5
- The paper
- Zhang, J., Houston, D. W., King, M. L., Payne, C., Wylie, C., & Heasman, J. (1998). The Role of Maternal VegT in Establishing the Primary Germ Layers in Xenopus Embryos. Cell. https://doi.org/10.1016/s0092-8674(00)81592-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
