The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Endodermal Nodal-related signals and mesoderm induction in Xenopus
Open accessAbstract
In Xenopus, mesoderm induction by endoderm at the blastula stage is well documented, but the molecular nature of the endogenous inductive signals remains unknown. The carboxy-terminal fragment of Cerberus, designated Cer-S, provides a specific secreted antagonist of mesoderm-inducing Xenopus Nodal-Related (Xnr) factors. Cer-S does not inhibit signalling by other mesoderm inducers such as Activin, Derrière, Vg1 and BMP4, nor by the neural inducer Xnr3. In the present study we show that Cer-S blocks the induction of both dorsal and ventral mesoderm in animal-vegetal Nieuwkoop-type recombinants. During blastula stages Xnr1, Xnr2 and Xnr4 are expressed in a dorsal to ventral gradient in endodermal cells. Dose-response experiments using cer-S mRNA injections support the existence of an endogenous activity gradient of Xnrs. Xnr expression at blastula can be activated by the vegetal determinants VegT and Vg1 acting in synergy with dorsal β-catenin. The data support a modified model for mesoderm induction in Xenopus, in which mesoderm induction is mediated by a gradient of multiple Nodal-related signals released by endoderm at the blastula stage.
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Cites
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
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The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals
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Self-citationThe EGF-CFC Protein One-Eyed Pinhead Is Essential for Nodal Signaling
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Cited by
Kattman, S. J., Witty, A. D., Gagliardi, M., Dubois, N. C., Niapour, M., Hotta, A., Ellis, J., & Keller, G. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2010.12.008 · Cited by 1,159
DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN XENOPUS EMBRYOS
De Robertis, E. M., & Kuroda, H. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.011403.154124 · Cited by 671
The establishment of spemann's organizer and patterning of the vertebrate embryo
De Robertis, E. M., Larraín, J., Oelgeschläger, M., & Wessely, O. (2000) · Nature Reviews Genetics · doi:10.1038/35042039 · Cited by 429
Self-citationBorowiak, M., Maehr, R., Chen, S., Chen, A. E., Tang, W., Fox, J. L., Schreiber, S. L., & Melton, D. A. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.01.014 · Cited by 417
Conserved Patterns of Cell Movements during Vertebrate Gastrulation
Solnica-Krezel, L. (2005) · Current Biology · doi:10.1016/j.cub.2005.03.016 · Cited by 391
Metadata
- Authors
- Agius, E., Oelgeschläger, M., Wessely, O., Kemp, C., & Robertis, E. M. D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-03-15
- Volume
- 127
- Issue
- 6
- Pages
- 1173-1183
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2156212940
- Cited by
- 420
- References
- 60
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- green
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