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Crystal Structure of the PTEN Tumor Suppressor
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Citations
Cites
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302
Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., et al. (1997) · Science · doi:10.1126/science.275.5308.1943 · Cited by 4,785
Maehama, T., & Dixon, J. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13375 · Cited by 3,104
Self-citationA single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.
Davletov, B. A., & Südhof, T. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74326-9 · Cited by 480 · cited 1×
“In the positive control, the C2 domain of synaptotagmin bound thebers of the C2 family, such as the PKCd and synaptotagmin C2 domains (1.7 Å/85 Ca) (Pappa et al., 1998). vesicles in a Ca21-dependent manner, as reported (Dav- letov and Sudhof, 1993).”
BackgroundInfluential
Research works printed but not linked: 38
- Baraldi, 1999, Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate, Structure, 7, 449, 10.1016/S0969-2126(99)80057-4 · DOI · Paper page
- Barford, 1994, Crystal structure of human protein tyrosine phosphatase 1B, Science, 263, 1397, 10.1126/science.8128219 · DOI · Paper page
- Bittova, 1999, A structure-function study of the C2 domain of cytosolic phospholipase A2. Identification of essential calcium ligands and hydrophobic membrane binding residues, J. Biol. Chem., 274, 9665, 10.1074/jbc.274.14.9665 · DOI
- Brünger, 1998, Crystallography and NMR system, Acta Crystallogr. D Biol. Crystallogr., 54, 905, 10.1107/S0907444998003254 · DOI · Paper page
- Chapman, 1998, Direct interaction of a Ca2+-binding loop of synaptotagmin with lipid bilayers, J. Biol. Chem., 273, 13995, 10.1074/jbc.273.22.13995 · DOI · Paper page
- Chapman, 1994, Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes, Autonomous function of a single C, 2-homologous, 5735
- 1994, The CCP4 suite, Acta Crystallogr. D, 50, 760, 10.1107/S0907444994003112 · DOI · Paper page
- Davletov, 1998, Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically, J. Biol. Chem., 273, 19093, 10.1074/jbc.273.30.19093 · DOI
- Di Cristofano, 1998, Pten is essential for embryonic development and tumour suppression, Nat. Genet., 19, 348, 10.1038/1235 · DOI · Paper page
- Essen, 1996, Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta, Nature, 380, 595, 10.1038/380595a0 · DOI · Paper page
- Essen, 1997, A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-δ1, Biochemistry, 36, 2753, 10.1021/bi962466t · DOI
- Fukuda, 1996, Phospholipid composition dependence of Ca2+-dependent phospholipid binding to the C2A domain of synaptotagmin IV, J. Biol. Chem., 271, 8430, 10.1074/jbc.271.14.8430 · DOI
- Furnari, 1997, Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain, Proc. Natl. Acad. Sci. USA, 94, 12479, 10.1073/pnas.94.23.12479 · DOI · Paper page
- Furnari, 1998, The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells, Cancer Res., 58, 5002
- Georgescu, 1999, The tumor suppressor activity of PTEN is regulated by its carboxy-terminal region, Proc. Natl. Acad. Sci. USA, 96, 10182, 10.1073/pnas.96.18.10182 · DOI · Paper page
- Jia, 1995, Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B, Science, 268, 1754, 10.1126/science.7540771 · DOI · Paper page
- Jones, 1991, Improved methods for binding protein models in electron density maps and the location of errors in these models, Acta Crystallogr. A, 47, 110, 10.1107/S0108767390010224 · DOI · Paper page
- Li, 1998, PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells, Proc. Natl. Acad. Sci. USA, 95, 15406, 10.1073/pnas.95.26.15406 · DOI · Paper page
- Maehama, 1999, PTEN, Trends Cell Biol., 9, 125, 10.1016/S0962-8924(99)01519-6 · DOI · Paper page
- Miller, 1996, Protein fold recognition by sequence threading, FASEB J., 10, 171, 10.1096/fasebj.10.1.8566539 · DOI
- Myers, 1997, P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase, Proc. Natl. Acad. Sci. USA, 94, 9052, 10.1073/pnas.94.17.9052 · DOI · Paper page
- Myers, 1998, The lipid phosphatase activity of PTEN is critical for its tumor supressor function, Proc. Natl. Acad. Sci. USA, 95, 13513, 10.1073/pnas.95.23.13513 · DOI · Paper page
- Ogg, 1998, The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway, Mol. Cell, 2, 887, 10.1016/S1097-2765(00)80303-2 · DOI · Paper page
- Pappa, 1998, Crystal structure of the C2 domain from protein kinase C-δ, Structure, 6, 885, 10.1016/S0969-2126(98)00090-2 · DOI
- Perisic, 1998, Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2, J. Biol. Chem., 273, 1596, 10.1074/jbc.273.3.1596 · DOI · Paper page
- Podsypanina, 1999, Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems, Proc. Natl. Acad. Sci. USA, 96, 1563, 10.1073/pnas.96.4.1563 · DOI · Paper page
- Rizo, 1998, C2-domains, structure and function of a universal Ca2+-binding domain, J. Biol. Chem., 273, 15879, 10.1074/jbc.273.26.15879 · DOI · Paper page
- Singer, 1997, Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D, Annu. Rev. Biochem., 66, 475, 10.1146/annurev.biochem.66.1.475 · DOI · Paper page
- Stambolic, 1998, Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN, Cell, 95, 29, 10.1016/S0092-8674(00)81780-8 · DOI · Paper page
- Steck, 1997, Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers, Nat. Genet., 15, 356, 10.1038/ng0497-356 · DOI · Paper page
- Stuckey, 1994, Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate, Nature, 370, 571, 10.1038/370571a0 · DOI · Paper page
- Sun, 1999, PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway, Proc. Natl. Acad. Sci. USA, 96, 6199, 10.1073/pnas.96.11.6199 · DOI · Paper page
- Sutton, 1998, Structure of the protein kinase Cβ phospholipid-binding C2 domain complexed with Ca2+, Structure, 6, 1395, 10.1016/S0969-2126(98)00139-7 · DOI · Paper page
- Suzuki, 1998, High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice, Curr. Biol., 8, 1169, 10.1016/S0960-9822(07)00488-5 · DOI · Paper page
- Tamura, 1998, Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN, Science, 280, 1614, 10.1126/science.280.5369.1614 · DOI · Paper page
- Teng, 1997, MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines, Cancer Res., 57, 5221
- Wang, 1999, Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II, Cell, 98, 47, 10.1016/S0092-8674(00)80605-4 · DOI · Paper page
- Yuvaniyama, 1996, Crystal structure of the dual specificity protein phosphatase VHR, Science, 272, 1328, 10.1126/science.272.5266.1328 · DOI · Paper page
Cited by
The functions and regulation of the PTEN tumour suppressor
Song, M. S., Salmena, L., & Pandolfi, P. P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3330 · Cited by 1,926
Self-citationPhosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Synthesis and Function of 3-Phosphorylated Inositol Lipids
Vanhaesebroeck, B., Leevers, S. J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P. C., Woscholski, R., Parker, P. J., & Waterfield, M. D. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.535 · Cited by 1,535
The Multiple Roles of PTEN in Tumor Suppression
Di Cristofano, A., & Pandolfi, P. P. (2000) · Cell · doi:10.1016/s0092-8674(00)80674-1 · Cited by 1,182
Self-citationMicroenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
Zhang, L., Zhang, S., Yao, J., Lowery, F. J., Zhang, Q., Huang, W.-C., Li, P., Li, M., Wang, X., Zhang, C., et al. (2015) · Nature · doi:10.1038/nature15376 · Cited by 1,175
Metadata
- Authors
- Lee, J.-O., Yang, H., Georgescu, M.-M., Di Cristofano, A., Maehama, T., Shi, Y., Dixon, J. E., Pandolfi, P., & Pavletich, N. P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 99
- Issue
- 3
- Pages
- 323-334
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1939083266
- Cited by
- 1,014
- References
- 4
- FWCI
- 11.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 5038 d)
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- Lee, J.-O., Yang, H., Georgescu, M.-M., Di Cristofano, A., Maehama, T., Shi, Y., Dixon, J. E., Pandolfi, P., & Pavletich, N. P. (1999). Crystal Structure of the PTEN Tumor Suppressor. Cell. https://doi.org/10.1016/s0092-8674(00)81663-3
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