The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
REGULATION OF EUKARYOTIC PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C AND PHOSPHOLIPASE D
Abstract
This review focuses on two phospholipase activities involved in eukaryotic signal transduction. The action of the phosphatidylinositol-specific phospholipase C enzymes produces two well-characterized second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. This discussion emphasizes recent advances in elucidation of the mechanisms of regulation and catalysis of the various isoforms of these enzymes. These are especially related to structural information now available for a phospholipase C δ isozyme. Phospholipase D hydrolyzes phospholipids to produce phosphatidic acid and the respective head group. A perspective of selected past studies is related to emerging molecular characterization of purified and cloned phospholipases D. Evidence for various stimulatory agents (two small G protein families, protein kinase C, aand phosphoinositides) suggests complex regulatory mechanisms, and some studies suggest a role for this enzyme activity in intracellular membrane traffic.
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Cites
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Cited by
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046
Signaling Mechanisms Underlying the Vascular Myogenic Response
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Multiple roles of phosphoinositide-specific phospholipase C isozymes
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Rho-Kinase–Mediated Contraction of Isolated Stress Fibers
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Mammalian phospholipase D structure and regulation
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Metadata
- Authors
- Singer, W. D., Brown, H. A., & Sternweis, P. C.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1997-06
- Volume
- 66
- Issue
- 1
- Pages
- 475-509
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2112919363
- Cited by
- 401
- References
- 9
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Singer, W. D., Brown, H. A., & Sternweis, P. C. (1997). REGULATION OF EUKARYOTIC PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C AND PHOSPHOLIPASE D. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.66.1.475
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