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Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia
Open accessAbstract
N-methyl-D-aspartate receptors (NMDARs) represent a subclass of glutamate receptors that play a critical role in neuronal development and physiology. We report here the generation of mice expressing only 5% of normal levels of the essential NMDAR1 (NR1) subunit. Unlike NR1 null mice, these mice survive to adulthood and display behavioral abnormalities, including increased motor activity and stereotypy and deficits in social and sexual interactions. These behavioral alterations are similar to those observed in pharmacologically induced animal models of schizophrenia and can be ameliorated by treatment with haloperidol or clozapine, antipsychotic drugs that antagonize dopaminergic and serotonergic receptors. These findings support a model in which reduced NMDA receptor activity results in schizophrenic-like behavior and reveals how pharmacological manipulation of monoaminergic pathways can affect this phenotype.
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“Observational findings in some of these behavioral domains have been reported in some targeted gene mutations, e.g.deficits in social interaction within the home cage have been reported for mice deficient in the dishevelled-1 gene (Lijam et al. 1997) or the NMDA NR1 subunit (Mohn et al. 1999).”
From Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice (2004) · cites this paper as Mohn et al. 1999
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“In supporting of this notion, NMDAR antagonism during an equivalent period in rodents (first 2 post-natal weeks) induces long-lasting behavioural and cognitive disturbances that are relevant to the schizophrenia phenotype and which extend into adolescence and adulthood 10,27 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [27]
Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258
Recent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904
Heteromeric NMDA receptors: molecular and functional distinction of subtypes
Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B., & Seeburg, P. H. (1992) · Science · doi:10.1126/science.256.5060.1217 · Cited by 2,541
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476
Self-citationAntipsychotic drug doses and neuroleptic/dopamine receptors
SEEMAN, P., LEE, T., CHAU-WONG, M., & WONG, K. (1976) · Nature · doi:10.1038/261717a0 · Cited by 1,622
Crawley, J. N., Belknap, J. K., Collins, A. C., Crabbe, J. C., Frankel, W. N., Henderson, N. D., HITZEMANN, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., et al. (1997) · Psychopharmacology · doi:10.1007/s002130050327 · Cited by 1,372
Molecular diversity of the NMDA receptor channel
Kutsuwada, T., Kashiwabuchi, N., Mori, H., Sakimura, K., Kushiya, E., Araki, K., Meguro, H., Hisashi, M., Kumanishi, T., Arakawa, M., et al. (1992) · Nature · doi:10.1038/358036a0 · Cited by 1,352
HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells
Hooper, M., Hardy, K., Handyside, A. H., Hunter, S., & Monk, M. (1987) · Nature · doi:10.1038/326292a0 · Cited by 1,218
Carlsson, M. L., & Carlsson, A. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90108-m · Cited by 1,086
Research works printed but not linked: 2
- Ereshefsky, 1989, Clozapine, Clin. Pharm., 8, 691
- Rosenbauer, 1980, Studies concerning the formation of vaginal plug in laboratory animals and its suitability for demonstrating the ultrastructure of spermatazoa, Folia Morphol. (Praha), 28, 126
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Shim, S. S., Hammonds, M. D., & Kee, B. S. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0757-8 · Cited by 104
Crabtree, G. W., & Gogos, J. A. (2014) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2014.00028 · Cited by 106
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Hayashi, Y. (2022) · Neuroscience Research · doi:10.1016/j.neures.2021.08.001 · Cited by 102
Melone, M., Burette, A., & Weinberg, R. J. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20743 · Cited by 101
Rao, J. S., Kellom, M., Reese, E. A., Rapoport, S. I., & Kim, H. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.017 · Cited by 101
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Itokawa, M., Yamada, K., Yoshitsugu, K., Toyota, T., Suga, T., Ohba, H., Watanabe, A., Hattori, E., Shimizu, H., Kumakura, T., et al. (2003) · Pharmacogenetics · doi:10.1097/00008571-200305000-00006 · Cited by 98
Wang, C., McInnis, J., West, J. B., Bao, J., Anastasio, N. C., Guidry, J. A., Ye, Y., Salvemini, D., & Johnson, K. M. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.041798 · Cited by 98
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Guilarte, T. R., Opler, M. G., & Pletnikov, M. V. (2011) · NeuroToxicology · doi:10.1016/j.neuro.2011.11.008 · Cited by 97
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Brand, S., Moller, M., & Harvey, B. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150307004545 · Cited by 95
Rehn, A., van den Buuse, M., Copolov, D., Briscoe, T. A., Lambert, G. W., & Rees, S. M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.047 · Cited by 95
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Ramsey, A., Milenkovic, M., Oliveira, A. F., Escobedo-Lozoya, Y., Seshadri, S., Salahpour, A., Sawa, A., Yasuda, R., & Caron, M. (2011) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1012621108 · Cited by 83
Self-citationDopamine transporter mutant mice in experimental neuropharmacology
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Metadata
- Authors
- Mohn, A. R., Gainetdinov, R. R., Caron, M. G., & Koller, B. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Koller, Beverly H
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 98
- Issue
- 4
- Pages
- 427-436
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2164674870
- Cited by
- 1,075
- References
- 64
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 19 · 2023: 17 · 2022: 28 · 2021: 26 · 2020: 26 · 2019: 28 · 2018: 29 · 2017: 27 · 2016: 46 · 2015: 40 · 2014: 39 · 2013: 42 · 2012: 45
- FWCI
- 24.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007092, T32 GM07092)
- National Institute of Neurological Disorders and Stroke (NS-19576, R01NS019576)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- NMDA receptor, NR1 subunit, schizophrenia, mouse model, motor activity, stereotypy, social interaction deficits, antipsychotic drugs, haloperidol, clozapine, monoaminergic pathways, glutamate receptors
- MeSH terms
- Animals, Antisocial Personality Disorder, Behavior, Animal, Clozapine, Disease Models, Animal, Female, Haloperidol, Male, Motor Activity, Phencyclidine, Schizophrenic Psychology, Serotonin Antagonists, Sexual Behavior, Animal, Social Behavior, Stereotyped Behavior, Antipsychotic Agents, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Mice, Knockout, Dopamine Antagonists, Excitatory Amino Acid Antagonists, Glutamic Acid, Calcium Signaling, Mice
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