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Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia
Open accessAbstract
N-methyl-D-aspartate receptors (NMDARs) represent a subclass of glutamate receptors that play a critical role in neuronal development and physiology. We report here the generation of mice expressing only 5% of normal levels of the essential NMDAR1 (NR1) subunit. Unlike NR1 null mice, these mice survive to adulthood and display behavioral abnormalities, including increased motor activity and stereotypy and deficits in social and sexual interactions. These behavioral alterations are similar to those observed in pharmacologically induced animal models of schizophrenia and can be ameliorated by treatment with haloperidol or clozapine, antipsychotic drugs that antagonize dopaminergic and serotonergic receptors. These findings support a model in which reduced NMDA receptor activity results in schizophrenic-like behavior and reveals how pharmacological manipulation of monoaminergic pathways can affect this phenotype.
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“Observational findings in some of these behavioral domains have been reported in some targeted gene mutations, e.g.deficits in social interaction within the home cage have been reported for mice deficient in the dishevelled-1 gene (Lijam et al. 1997) or the NMDA NR1 subunit (Mohn et al. 1999).”
From Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice (2004) · cites this paper as Mohn et al. 1999
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“In supporting of this notion, NMDAR antagonism during an equivalent period in rodents (first 2 post-natal weeks) induces long-lasting behavioural and cognitive disturbances that are relevant to the schizophrenia phenotype and which extend into adolescence and adulthood 10,27 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [27]
Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258
Recent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904
Heteromeric NMDA receptors: molecular and functional distinction of subtypes
Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B., & Seeburg, P. H. (1992) · Science · doi:10.1126/science.256.5060.1217 · Cited by 2,541
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476
Self-citationAntipsychotic drug doses and neuroleptic/dopamine receptors
SEEMAN, P., LEE, T., CHAU-WONG, M., & WONG, K. (1976) · Nature · doi:10.1038/261717a0 · Cited by 1,622
Crawley, J. N., Belknap, J. K., Collins, A. C., Crabbe, J. C., Frankel, W. N., Henderson, N. D., HITZEMANN, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., et al. (1997) · Psychopharmacology · doi:10.1007/s002130050327 · Cited by 1,372
Molecular diversity of the NMDA receptor channel
Kutsuwada, T., Kashiwabuchi, N., Mori, H., Sakimura, K., Kushiya, E., Araki, K., Meguro, H., Hisashi, M., Kumanishi, T., Arakawa, M., et al. (1992) · Nature · doi:10.1038/358036a0 · Cited by 1,352
HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells
Hooper, M., Hardy, K., Handyside, A. H., Hunter, S., & Monk, M. (1987) · Nature · doi:10.1038/326292a0 · Cited by 1,218
Carlsson, M. L., & Carlsson, A. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90108-m · Cited by 1,086
Research works printed but not linked: 2
- Ereshefsky, 1989, Clozapine, Clin. Pharm., 8, 691
- Rosenbauer, 1980, Studies concerning the formation of vaginal plug in laboratory animals and its suitability for demonstrating the ultrastructure of spermatazoa, Folia Morphol. (Praha), 28, 126
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Norgaard-Nielsen, K., & Gether, U. (2006) · Springer eBooks · doi:10.1007/3-540-29784-7_1 · Cited by 25
Pisu, M. B., Guioli, S., Conforti, E., & Bernocchi, G. (2003) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.08.007 · Cited by 23
Taylor, G. T., Maloney, S. E., Dearborn, J. T., & Weiss, J. (2009) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/187152409789630398 · Cited by 23
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Matsuno, H., Ohi, K., Hashimoto, R., Yamamori, H., Yasuda, Y., Fujimoto, M., Umeda‐Yano, S., Saneyoshi, T., Takeda, M., & Hayashi, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116319 · Cited by 23
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Morita, Y., Ujike, H., Tanaka, Y., Kishimoto, M., Okahisa, Y., Kotaka, T., Harano, M., Inada, T., Komiyama, T., Hori, T., et al. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30565 · Cited by 23
Ardayfio, P. A., Benvenga, M. J., Chaney, S. F., Love, P. L., Catlow, J. T., Swanson, S. P., & Marek, G. J. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.143370 · Cited by 23
Elmer, G. I., Sydnor, J., GUARD, H. L., Hercher, E., & Vogel, M. W. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1757-7 · Cited by 23
Ceccarelli, S. M., Pinard, E., Stalder, H., & Alberati, D. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.09.067 · Cited by 23
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Holahan, M. R., Clarke, M., & Hines, D. D. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1959-8 · Cited by 24
Mihali, A., Subramani, S., Kaunitz, G. J., Rayport, S., & Gaisler‐Salomon, I. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.60 · Cited by 22
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Lu, L., Mamiya, T., Koseki, T., Mouri, A., & Nabeshima, T. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1358 · Cited by 22
Yasuda, K., Hayashi, Y., Yoshida, T., Kashiwagi, M., Nakagawa, N., Michikawa, T., Tanaka, M., Ando, R., Huang, A. J. Y., Hosoya, T., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.19 · Cited by 22
Bickel, S., Lipp, H., & Umbricht, D. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00283.x · Cited by 22
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Ninan, I., Jardemark, K. E., Liang, X., & Wang, R. Y. (2003) · Synapse · doi:10.1002/syn.10175 · Cited by 22
Pieri, M. D., Sabé, M., Rochas, V., Poglia, G., Bartolomei, J., Kirschner, M., & Kaiser, S. (2025) · Schizophrenia · doi:10.1038/s41537-025-00596-z · Cited by 23
Nagano, T., Mizuno, M., Morita, K., & Nawa, H. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_399 · Cited by 21
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Wang, X., Zhao, J., Hu, Y., Jiao, Z., Lu, Y., Ding, M., Kou, Y., Li, B., Meng, F., Zhao, H., et al. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.08.079 · Cited by 21
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Hung, C., Chen, H., & Chen, C. (2002) · Psychiatric Genetics · doi:10.1097/00041444-200212000-00005 · Cited by 21
Hirai, T., Taniura, H., Goto, Y., Tamaki, K., Oikawa, H., Kambe, Y., Ogura, M., Ohno, Y., Takarada, T., & Yoneda, Y. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20497 · Cited by 21
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Maskos, U., & McKay, R. D. G. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00354-3 · Cited by 19
Hashimoto, A., Konno, R., Yano, H., Yoshikawa, M., Tamaki, R., Matsumoto, H., & Kobayashi, H. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.03.031 · Cited by 20
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Inada, K., Ishigooka, J., Anzai, T., Suzuki, E., Miyaoka, H., & Saji, M. (2003) · Neuroscience Research · doi:10.1016/s0168-0102(03)00012-9 · Cited by 20
Remali, J., & Aizat, W. M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38986 · Cited by 21
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Standley, S., Petralia, R. S., Gravell, M., Hamilton, R. S., Wang, Y., Schubert, M., & Wenthold, R. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039585 · Cited by 18
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Self-citationDel’Guidice, T., & Beaulieu, J. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.046540 · Cited by 18
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Amici, M., Lee, Y., Pope, R. J. P., Bradley, C. A., Cole, A. R., & Collingridge, G. L. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14841 · Cited by 17
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Wang, X., Gu, Z., Zhong, P., Chen, G., Feng, J., & Yan, Z. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.08.018 · Cited by 16
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Bodarky, C. L., Halene, T. B., Ehrlichman, R. S., Banerjee, A., Ray, R., Hahn, C.-G., Jonak, G. J., & Siegel, S. J. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.150938 · Cited by 16
Holahan, M. R., Westby, E. P., & Albert, K. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.11.044 · Cited by 16
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Hattori, Y., Matsuda, S., Baba, R., Matsumiya, K., Iwasaki, S., Constantinescu, C. C., Morley, T. J., Carroll, V. M., Papin, C., Gouasmat, A., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01937 · Cited by 16
Mahadevan, V., Mitra, A., Zhang, Y., Yuan, X. Q., Peltekian, A., Chittajallu, R., Esnault, C., Maric, D., Rhodes, C. T., Pelkey, K. A., et al. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.712609 · Cited by 19
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Gao, Y., Ding, Y., Shi, R., & Tian, Y. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2008.07.004 · Cited by 16
Hamada, S., Ogawa, I., Yamasaki, M., Kiyama, Y., Kassai, H., Watabe, A. M., Nakao, K., Aiba, A., Watanabe, M., & Manabe, T. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12682 · Cited by 17
Inada, K., Farrington, J., Moy, S. S., Koller, B. H., & Duncan, G. E. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0628-5 · Cited by 16
Self-citationMcClatchy, D. B., Savas, J. N., Martínez‐Bartolomé, S., Park, S. K., Maher, P. A., Powell, S. B., & Yates, J. R. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.41 · Cited by 14
Cox, D., Gottschalk, M. G., Wesseling, H., Ernst, A., Cooper, J. D., & Bahn, S. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.06.012 · Cited by 16
Liu, Y.-P., Ding, M., Zhang, X., Liu, Y., Xuan, J., Xing, J., Xia, X., Yao, J., & Wang, B. (2019) · BMC Medical Genetics · doi:10.1186/s12881-019-0757-3 · Cited by 16
GSA: behavioral, histological, electrophysiological and neurochemical effects
Torremans, A., Marescau, B., Dam, D. V., Ginneken, C. J. V., Meir, F. V., van Bogaert, P., D’Hooge, R., de Vente, J., & Deyn, P. P. D. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.12.001 · Cited by 16
Staats, K. A., Seah, C., Sahimi, A., Wang, Y., Koutsodendris, N., Lin, S., Kim, D., Chang, W.-H., Gray, K. A., Shi, Y., et al. (2019) · doi:10.1101/685800 · Cited by 16
Kim, N.-S., Ringeling, F. R., Zhou, Y., Nguyen, H. N., Temme, S. J., Lin, Y.-T., Eacker, S., Dawson, V. L., Dawson, T. M., Xiao, B., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.04.023 · Cited by 15
Glass, M. J., Robinson, D. C., Waters, E. M., & Pickel, V. M. (2013) · Synapse · doi:10.1002/syn.21637 · Cited by 15
Saadat, M. (2010) · Europe PMC (PubMed Central) · doi:10.17877/de290r-12750 · Cited by 14
Sociability development in mice with cell-specific deletion of the NMDA receptor NR1 subunit gene
Ferri, S. L., Pallathra, A. A., Kim, H., Dow, H. C., Raje, P., McMullen, M., Bilker, W. B., Siegel, S. J., Abel, T., & Brodkin, E. S. (2020) · Genes, Brain and Behavior · doi:10.1111/gbb.12624 · Cited by 15
Inta, D., Vogt, M. A., Pfeiffer, N., Köhr, G., & Gass, P. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.03.036 · Cited by 15
Effects of Methyl Mercury Chloride on Rat Hippocampus Structure
Wu, J., Cheng, G., Lu, Z., Wang, M., Tian, J., & Bi, Y. (2015) · Biological Trace Element Research · doi:10.1007/s12011-015-0492-3 · Cited by 15
Diana, M. C., Santoro, M. L., Xavier, G., Santos, C. M., Spíndola, L., Moretti, P. N. S., Ota, V., Bressan, R. A., Abílio, V. C., & Belangero, S. I. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.08.021 · Cited by 16
Metadata
- Authors
- Mohn, A. R., Gainetdinov, R. R., Caron, M. G., & Koller, B. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Koller, Beverly H
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 98
- Issue
- 4
- Pages
- 427-436
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2164674870
- Cited by
- 1,075
- References
- 64
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 19 · 2023: 17 · 2022: 28 · 2021: 26 · 2020: 26 · 2019: 28 · 2018: 29 · 2017: 27 · 2016: 46 · 2015: 40 · 2014: 39 · 2013: 42 · 2012: 45
- FWCI
- 24.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007092, T32 GM07092)
- National Institute of Neurological Disorders and Stroke (NS-19576, R01NS019576)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- NMDA receptor, NR1 subunit, schizophrenia, mouse model, motor activity, stereotypy, social interaction deficits, antipsychotic drugs, haloperidol, clozapine, monoaminergic pathways, glutamate receptors
- MeSH terms
- Animals, Antisocial Personality Disorder, Behavior, Animal, Clozapine, Disease Models, Animal, Female, Haloperidol, Male, Motor Activity, Phencyclidine, Schizophrenic Psychology, Serotonin Antagonists, Sexual Behavior, Animal, Social Behavior, Stereotyped Behavior, Antipsychotic Agents, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Mice, Knockout, Dopamine Antagonists, Excitatory Amino Acid Antagonists, Glutamic Acid, Calcium Signaling, Mice
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