The DOI matches its Crossref record; 63 of the 64 references it cites were found in a registry or an index.
Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia
Open accessAbstract
N-methyl-D-aspartate receptors (NMDARs) represent a subclass of glutamate receptors that play a critical role in neuronal development and physiology. We report here the generation of mice expressing only 5% of normal levels of the essential NMDAR1 (NR1) subunit. Unlike NR1 null mice, these mice survive to adulthood and display behavioral abnormalities, including increased motor activity and stereotypy and deficits in social and sexual interactions. These behavioral alterations are similar to those observed in pharmacologically induced animal models of schizophrenia and can be ameliorated by treatment with haloperidol or clozapine, antipsychotic drugs that antagonize dopaminergic and serotonergic receptors. These findings support a model in which reduced NMDA receptor activity results in schizophrenic-like behavior and reveals how pharmacological manipulation of monoaminergic pathways can affect this phenotype.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Observational findings in some of these behavioral domains have been reported in some targeted gene mutations, e.g.deficits in social interaction within the home cage have been reported for mice deficient in the dishevelled-1 gene (Lijam et al. 1997) or the NMDA NR1 subunit (Mohn et al. 1999).”
From Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice (2004) · cites this paper as Mohn et al. 1999
In the citing paper
“In supporting of this notion, NMDAR antagonism during an equivalent period in rodents (first 2 post-natal weeks) induces long-lasting behavioural and cognitive disturbances that are relevant to the schizophrenia phenotype and which extend into adolescence and adulthood 10,27 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [27]
Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258
Recent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904
Heteromeric NMDA receptors: molecular and functional distinction of subtypes
Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B., & Seeburg, P. H. (1992) · Science · doi:10.1126/science.256.5060.1217 · Cited by 2,541
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476
Self-citationAntipsychotic drug doses and neuroleptic/dopamine receptors
SEEMAN, P., LEE, T., CHAU-WONG, M., & WONG, K. (1976) · Nature · doi:10.1038/261717a0 · Cited by 1,622
Crawley, J. N., Belknap, J. K., Collins, A. C., Crabbe, J. C., Frankel, W. N., Henderson, N. D., HITZEMANN, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., et al. (1997) · Psychopharmacology · doi:10.1007/s002130050327 · Cited by 1,372
Molecular diversity of the NMDA receptor channel
Kutsuwada, T., Kashiwabuchi, N., Mori, H., Sakimura, K., Kushiya, E., Araki, K., Meguro, H., Hisashi, M., Kumanishi, T., Arakawa, M., et al. (1992) · Nature · doi:10.1038/358036a0 · Cited by 1,352
HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells
Hooper, M., Hardy, K., Handyside, A. H., Hunter, S., & Monk, M. (1987) · Nature · doi:10.1038/326292a0 · Cited by 1,218
Carlsson, M. L., & Carlsson, A. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90108-m · Cited by 1,086
Research works printed but not linked: 2
- Ereshefsky, 1989, Clozapine, Clin. Pharm., 8, 691
- Rosenbauer, 1980, Studies concerning the formation of vaginal plug in laboratory animals and its suitability for demonstrating the ultrastructure of spermatazoa, Folia Morphol. (Praha), 28, 126
Cited by
Sorted by citations
Items 801–900 of 1,000
Yum, S. Y., Hwang, M. Y., Nasrallah, H. A., & Opler, L. A. (2016) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2016.01.007 · Cited by 6
Du, X., McCarthny, C. R., Notaras, M. J., van den Buuse, M., & Hill, R. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.03.005 · Cited by 6
Frye, C. A., Qrareya, A. N., Llaneza, D. C., & Paris, J. J. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00011 · Cited by 6
Cai, S., Lv, Y., Huang, K., Zhang, W., Wang, Q., Huang, L., & Wang, J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00351 · Cited by 6
Li, W., Su, X., Chen, T., Li, Z., Yang, Y., Zhang, L., Liu, Q., Shao, M., Zhang, Y., Ding, M., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.559210 · Cited by 6
Activation of A2Badenosine receptor protects against demyelination in a mouse model of schizophrenia
Ma, Q., Wang, D., Li, Y., Yang, H., Li, Y., Wang, J., Li, J., Sun, J., & Liu, J. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11323 · Cited by 6
Role of pharmacogenomics in drug development
Hakonarson, H. H., & Stefánsson, K. (2004) · Drug Development Research · doi:10.1002/ddr.10367 · Cited by 6
Response to Comment on "Diverse Psychotomimetics Act Through a Common Signaling Pathway"
Svenningsson, P., Nomikos, G. G., & Greengard, P. (2004) · Science · doi:10.1126/science.1097564 · Cited by 6
Theory of mind in schizophrenia: Damaged module or deficit in cognitive coordination?
Leiser, D., & Bonshtein, U. (2003) · Behavioral and Brain Sciences · doi:10.1017/s0140525x03350022 · Cited by 6
Combined effect of polymorphic sites in the DTNBP1 and GRIN1 genes on schizophrenia
Galehdari, H., Ajam, T., Pooryasin, A., Mohammad, F. A., & Reza, K. S. (2010) · Medical Journal of the Islamic Republic of Iran · Cited by 6
Petralia, R. S., & Wenthold, R. J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-055-3_2 · Cited by 7
Cognitive coordination and its neurobiological bases: A new continent to explore
Silverstein, S. M., & Phillips, W. A. (2003) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0349002x · Cited by 6
Bressler, S. L. (2003) · Behavioral and Brain Sciences · doi:10.1017/s0140525x03250020 · Cited by 6
Evenden, J. L. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1184-1 · Cited by 6
Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice
Chen, Y., Milenkovic, M., Horsfall, W., Salahpour, A., Soderling, S. H., & Ramsey, A. J. (2018) · PLOS ONE · doi:10.1371/journal.pone.0199341 · Cited by 5
Electrophysiological Deficits in Schizophrenia: Models and Mechanisms
von Reyn, C. R., Michael, E., Freedman, R., Valerie, M., Michael, J., Chinn, G. A., & Steven, J. (2011) · InTech eBooks · doi:10.5772/27511 · Cited by 5
Phenotypes associated with psychiatric disorders are sex-specific in a mutant mouse line.
Nakajima, M., Watanabe, T., Aoki, R., Shimizu, R., Okuyama, S., & Furukawa, Y. (2016) · Brain Research · doi:10.1016/j.brainres.2016.09.037 · Cited by 4
Detecting synaptic autoantibodies in psychoses: need for more sensitive methods
Masdeu, J. C. (2017) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000447 · Cited by 5
Dubovyk, V., & Manahan‐Vaughan, D. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00017 · Cited by 5
Yoshida, M., Hasegawa, S., Taniguchi, M., Mouri, A., Suzuki, C., Yoshimi, A., Mamiya, T., Ozaki, N., & Noda, Y. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109208 · Cited by 5
Lu, C., Chang, H., Hsu, L., Lee, M., Cheng, J., Wu, D., & Lin, W. (2023) · Pharmaceuticals · doi:10.3390/ph16020280 · Cited by 5
How and Why to Apply the Latest Technology*
Czarnik, A. W., & Mei, H. (2007) · Elsevier eBooks · doi:10.1016/b0-08-045044-x/00048-1 · Cited by 6
Gottschalk, M. G., Sarnyai, Z., Guest, P. C., Harris, L. W., & Bahn, S. (2012) · Archives of Clinical Psychiatry (São Paulo) · doi:10.1590/s0101-60832012005000007 · Cited by 5
NMDA synapses can bias competition between object representations and mediate attentional selection
Raffone, A., Murre, J. M. J., & Wolters, G. (2003) · Behavioral and Brain Sciences · doi:10.1017/s0140525x03400022 · Cited by 6
Impact of Transgenic Technologies on Functional Genomics
Shashikant, C. S., & Ruddle, F. H. (2003) · Current Issues in Molecular Biology · doi:10.21775/cimb.005.075 · Cited by 5
3.2 Role of Dopamine Transporters in Neuronal Homeostasis
Caron, M. G., & Gainetdinov, R. R. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195373035.003.0007 · Cited by 5
Self-citationMolecular Properties and Cell Biology of the NMDA Receptor
Wenthold, R. J., Al‐Hallaq, R. A., Swanwick, C. C., & Petralia, R. S. (2008) · Springer eBooks · doi:10.1007/978-0-387-77232-5_12 · Cited by 5
Altered higher brain function in PACAP-knockout mice
Shintani, N., Hashimoto, H., & Akemichi, B. A. B. A. (2004) · Folia Pharmacologica Japonica · doi:10.1254/fpj.123.274 · Cited by 5
Animal Models of Schizophrenia
Lipska, B. K., & Weinberger, D. R. (2003) · Wiley eBooks · doi:10.1002/9780470987353.ch21 · Cited by 6
Santos‐Gómez, A., Juliá‐Palacios, N., Rejano‐Bosch, A., Marí-Vico, R., Míguez‐Cabello, F., Masana, M., Soto, D., Olivella, M., García‐Cazorla, À., & Altafaj, X. (2025) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.70015 · Cited by 4
Sim, K., Lee, J., Subramaniam, M., Liu, J., Keefe, R. S. E., Zhang, X. D., Lee, T.-S. W., & Chong, S. A. (2011) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2011.00272.x · Cited by 4
Carlson, K. M., & Wagner, G. C. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.08.043 · Cited by 4
Epinephrine potentiates antipsychotic, but not cataleptogenic effect of haloperidol in rats
Гмиро, В. Е., & Serdyuk, S. E. (2007) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-007-0197-5 · Cited by 4
Endocrinology of bone/brain crosstalk
Metozzi, A., Bonamassa, L., Brandi, G., & Brandi, M. L. (2015) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2015.979787 · Cited by 4
Dutar, P., Tolle, V., Kervern, M., Carcenac, C., Carola, V., Gross, C. T., Savasta, M., Darmon, M. C., & Masson, J. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.11.022 · Cited by 4
Frӧhlich, F. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801560-5.00025-2 · Cited by 4
The Organization and Integrative Function of the Post-Synaptic Proteome
Grant, S. G. N., Husi, H., Choudhary, J. S., Cumiskey, M. A., Blackstock, W. P., & Armstrong, J. D. (2003) · Springer eBooks · doi:10.1007/978-1-4615-0039-1_2 · Cited by 4
Peeling the onion: NMDA dysfunction as a unifying model in schizophrenia
Javitt, D. C. (2003) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0333002x · Cited by 4
Glutamate and Schizophrenia and the N-Methyl-d-Aspartate Receptor Hypofunction Hypothesis
Bleich, S., & Kornhuber, J. (2005) · Humana Press eBooks · doi:10.1007/978-1-59259-852-6_7 · Cited by 4
Genetic Markers in Psychiatric Genetics
Bourgeron, T., & Giros, B. (2003) · Humana Press eBooks · doi:10.1385/1-59259-348-8:63 · Cited by 4
Schizophrenic cognition: Taken out of context?
Hemsley, D. R. (2003) · Behavioral and Brain Sciences · doi:10.1017/s0140525x03310027 · Cited by 4
Mahadevan, V., Mitra, A., Zhang, Y., Yuan, X. Q., Peltekian, A., Chittajallu, R., Esnault, C., Maric, D., Rhodes, C. T., Pelkey, K. A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.10.144295 · Cited by 4
β-hydroxybutyrate improves convulsions in mice carrying the GRIN1 Y647S/+ pathogenic variantPreprint
Sullivan, M. T., Tidball, P., Yan, Y., Intson, K., Chen, W., Xu, Y., Venkatesan, S., Horsfall, W., Georgiou, J., Finnie, P. S. B., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.21.608984 · Cited by 4
Onaka, Y., Yamaguchi, T., Yamasaki, T., Morishige, K., & Yoneyama, M. (2025) · Neuropsychopharmacology Reports · doi:10.1002/npr2.70014 · Cited by 3
Emerging Roles of GluN3B NMDA Receptor Subunit in the Central Nervous System
Huang, Y., Xie, J., Chen, J., Guo, S., Li, Y., & Liu, F. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01523-z · Cited by 3
Modeling Schizophrenia in Neuregulin 1 and ErbB4 Mutant Mice
Lu, Y., Yin, D., Xiong, W., & Mei, L. (2011) · Neuromethods · doi:10.1007/978-1-61779-157-4_12 · Cited by 3
Animal Models of Schizophrenia with a Focus on Models Targeting NMDA Receptors
Svojanovská, M., & Stuchlı́k, A. (2015) · Cognitive Remediation Journal · doi:10.5507/crj.2015.001 · Cited by 3
Rajagopal, L., Mahjour, S., Huang, M., Ryan, C., Elzokaky, A., Csakai, A., Orr, M. J., Scheidt, K. A., & Meltzer, H. Y. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114614 · Cited by 3
Lipina, T. V., Giang, H., Thacker, J. S., Wetsel, W. C., Caron, M. G., Beaulieu, J., Salahpour, A., & Ramsey, A. J. (2024) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyae060 · Cited by 3
Self-citationSerine Racemase Knockout Mice: Neurotoxicity, Epilepsy, and Schizophrenia
Inoue, R., & Mori, H. (2016) · Springer eBooks · doi:10.1007/978-4-431-56077-7_8 · Cited by 3
Role of Glycine in Schizophrenia
Kretschmer, B. D. (2005) · Humana Press eBooks · doi:10.1007/978-1-59259-852-6_8 · Cited by 3
Establishment of L-3,4-Dihydroxyphenilalaninde-induced pharmacological dementia model mouse
Itokazu, N., Yamamoto, K., Ouchi, Y., & Cyong, J. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01823-7 · Cited by 3
Biochemical and genetic aspects of pathogenesis of schizophrenia
Камбарова, Д. К., & Golubev, A. G. (2011) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093011050021 · Cited by 3
Titone, D. A., & Debruille, J. B. (2003) · Behavioral and Brain Sciences · doi:10.1017/s0140525x03470027 · Cited by 3
d-Amino Acid Oxidase and d-Aspartate Oxidase
Kato, Y., Tran, D. H., Trinh, H. T. T., & Fukui, K. (2016) · Springer eBooks · doi:10.1007/978-4-431-56077-7_19 · Cited by 3
Mori, H. (2017) · Springer eBooks · doi:10.1007/978-3-319-49795-2_1 · Cited by 3
Mallien, A. S., Pfeiffer, N., Vogt, M. A., Chourbaji, S., Sprengel, R., Gass, P., & Inta, D. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.750106 · Cited by 3
A Historical Perspective on the Dopamine D3 Receptor
Sokoloff, P., & Foll, B. L. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_315 · Cited by 3
Стрелец, В. Б. (2003) · Behavioral and Brain Sciences · doi:10.1017/s0140525x03440028 · Cited by 3
Biss, M. (2015) · Cited by 3
Wu, Q., & Maniatis, T. (2000) · The Neuroscientist · doi:10.1177/107385840000600104 · Cited by 3
TAAR1 modulates cortical glutamate NMDA receptor function
Espinoza, S. (2016) · Intrinsic Activity · doi:10.25006/ia.4.s2-a18.75 · Cited by 3
Farsi, Z., Nicolella, A. A., Simmons, S., Aryal, S., Shepard, N., Brenner, K. S., Lin, S., Herzog, L. E., Shin, W., Gazestani, V., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.15.516665 · Cited by 2
Chronic social stress in early life can predispose mice to antisocial maltreating behavior
Jeon, D., Kim, S., Lee, S. K., & Chu, K. (2024) · encephalitis · doi:10.47936/encephalitis.2023.00199 · Cited by 2
Xue, L., Zhao, J., Liu, X., Zhao, T., Zhang, Y., & Ye, H. (2024) · Epigenetics · doi:10.1080/15592294.2024.2417158 · Cited by 2
Matsuda, S., Hattori, Y., & Kimura, H. (2024) · Advances in pharmacology · doi:10.1016/bs.apha.2024.10.017 · Cited by 2
MORRIS, B. J. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111628 · Cited by 2
Meta-analyses of nine polymorphisms of six genes with the risk of schizophrenia
Xu, X., Wang, L., Liao, Q., Xu, L., Huang, Y., Zhang, F., Cheng, J. R., Ye, M., Gao, S., & Duan, S. (2014) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2014.52012 · Cited by 2
Sheffler, D. J., & Conn, P. J. (2010) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0346-0241-9_6 · Cited by 2
Mielnik, C. A., Li, C. K., Ramsey, A. J., Salahpour, A., Burnham, W. M., & Ross, R. A. (2022) · Cannabis and Cannabinoid Research · doi:10.1089/can.2022.0125 · Cited by 2
Lamarque, M. D., Psimaras, D., Ducray, F., Pélieu, I., Sonneville, R., Demeret, S., Bolgert, F., Dehais, C., Camdessanché, J., Antoine, J.-C. G., et al. (2011) · Réanimation · doi:10.1007/s13546-011-0275-6 · Cited by 2
Mahmood, D., Pillai, K. K., Khanam, R., Jahan, K., Goswami, D., & Akhtar, M. (2015) · Journal of Experimental Neuroscience · doi:10.4137/jen.s27244 · Cited by 2
Phenomenology, context, and self-experience in schizophrenia
Sass, L. A., & Uhlhaas, P. J. (2003) · Behavioral and Brain Sciences · doi:10.1017/s0140525x03430021 · Cited by 2
Farrelly, L. A., Föcking, M., & Cotter, D. (2014) · Advances in biological psychiatry · doi:10.1159/000358028 · Cited by 2
[Stress and animal model of psychiatric disease].
Miyakawa, T., & Yamasaki, N. (2005) · Folia Pharmacologica Japonica · doi:10.1254/fpj.126.189 · Cited by 2
[Dysfunction of glutamatergic systems and potential animal models of schizophrenia].
Mouri, A., Noda, Y., Mizoguchi, H., & Nabeshima, T. (2006) · Folia Pharmacologica Japonica · doi:10.1254/fpj.127.4 · Cited by 2
Desbonnet, L. (2015) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-800981-9.00016-x · Cited by 3
Behavioral Phenotypes of Genetic Mouse Models
Moran, P. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801829-3.00029-x · Cited by 2
Lack of barbering behavior in the phospholipase Cβ1 mutant mouse: a model animal for schizophrenia
Shin, H., Kim, D., & Koh, H.-Y. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511676109.008 · Cited by 2
Neuroimaging and the At-Risk Mental State
Lin, Y.-S., Fusar‐Poli, P., & Borgwardt, S. (2019) · Springer eBooks · doi:10.1007/978-3-319-97307-4_6 · Cited by 2
Reduced expression of synapsin II in a chronic phencyclidine preclinical rat model of schizophrenia
Thomson, S., Dyck, B. A., Daya, R. P., Ho, J., Bernardo, A. M., Tian, Y., & Mishra, R. K. (2018) · Synapse · doi:10.1002/syn.22084 · Cited by 2
Ionotropic Glutamate Receptors (and Their Role in Health and Disease)
Sprengel, R., & Eltokhi, A. (2022) · Springer eBooks · doi:10.1007/978-1-4614-6434-1_4-3 · Cited by 2
Yabuki, Y., Nakagawasai, O., Tadano, T., & Fukunaga, K. (2013) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.12-00278-3 · Cited by 2
Phenomenology and Clinical Science of Schizophrenia
Ghose, S., & Tamminga, C. A. (2007) · Wiley eBooks · doi:10.1002/9780470101001.hcn029 · Cited by 2
Pharmacogenomics and animal models of schizophrenia
Klink, R., Boksa, P., & Joober, R. (2003) · Drug Development Research · doi:10.1002/ddr.10288 · Cited by 2
Hammond, L. E., Castanotto, D., Rice, S. R., Nimgaonkar, V. L., Wirshing, D. A., Rossi, J. J., Heston, L. L., & Sobell, J. L. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10646 · Cited by 2
Neue Ergebnisse in der genetischen Forschung bei schizophrenen Psychosen
Rujescu, D. (2010) · Springer eBooks · doi:10.1007/978-3-211-92215-6_9 · Cited by 2
Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown micePreprint
Chen, Y., Milenkovic, M., Salahpour, A., Soderling, S. H., & Ramsey, A. J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/341479 · Cited by 2
Mice Lacking PACAP: A Minireview Focussing on the Brain Function
Shintani, N. (2004) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.124.667 · Cited by 2
Animal Models for Schizophrenia: A Brief Overview
Furuta, M., & Kunugi, H. (2008) · Springer eBooks · doi:10.1007/978-0-387-79251-4_7 · Cited by 2
Roger, R. D., & Whittington, M. A. (2010) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195342796.003.0011 · Cited by 1
Ionotropic Glutamate Receptors (and Their Role in Health and Disease)
Sprengel, R., & Eltokhi, A. (2022) · Springer eBooks · doi:10.1007/978-3-030-88832-9_4 · Cited by 1
Faustmann, T. J., Theiss, S., Görtz, P., & Lange‐Asschenfeldt, C. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177810 · Cited by 1
Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials
Nguyen, T. V. H., McKernan, D. P., & Kelly, J. P. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70284 · Cited by 1
Yu, J., Choi, I. S., Kim, G. H., Bahn, S.-K., Kim, J., Bae, S., Lee, T., Choi, J. H., Kwon, J. S., Kim, M., et al. (2026) · Science Advances · doi:10.1126/sciadv.aee2152 · Cited by 1
Linking brain to mind in normal behavior and schizophrenia
Grossberg, S. (2003) · Behavioral and Brain Sciences · doi:10.1017/s0140525x03300020 · Cited by 1
Evans, K. L. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(99)01619-6 · Cited by 1
Evaluation of latent learning in a water-finding test by using model animals
Mouri, A., Noda, Y., & Nabeshima, T. (2007) · Folia Pharmacologica Japonica · doi:10.1254/fpj.130.141 · Cited by 1
Abazyan, S., & Pletnikov, M. V. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.017 · Cited by 1
Anti-schizophrenic activities of histamine H3 receptor antagonists in rats treated with MK-801
Mahmood, D., & Akhtar, M. (2015) · Journal of Pre-Clinical and Clinical Research · doi:10.5604/18982395.1157569 · Cited by 1
Metadata
- Authors
- Mohn, A. R., Gainetdinov, R. R., Caron, M. G., & Koller, B. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Koller, Beverly H
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 98
- Issue
- 4
- Pages
- 427-436
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2164674870
- Cited by
- 1,075
- References
- 64
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 19 · 2023: 17 · 2022: 28 · 2021: 26 · 2020: 26 · 2019: 28 · 2018: 29 · 2017: 27 · 2016: 46 · 2015: 40 · 2014: 39 · 2013: 42 · 2012: 45
- FWCI
- 24.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007092, T32 GM07092)
- National Institute of Neurological Disorders and Stroke (NS-19576, R01NS019576)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- NMDA receptor, NR1 subunit, schizophrenia, mouse model, motor activity, stereotypy, social interaction deficits, antipsychotic drugs, haloperidol, clozapine, monoaminergic pathways, glutamate receptors
- MeSH terms
- Animals, Antisocial Personality Disorder, Behavior, Animal, Clozapine, Disease Models, Animal, Female, Haloperidol, Male, Motor Activity, Phencyclidine, Schizophrenic Psychology, Serotonin Antagonists, Sexual Behavior, Animal, Social Behavior, Stereotyped Behavior, Antipsychotic Agents, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Mice, Knockout, Dopamine Antagonists, Excitatory Amino Acid Antagonists, Glutamic Acid, Calcium Signaling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review