Cited by 402RNA Research and SplicingNuclear Structure and FunctionRNA and protein synthesis mechanisms

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A Conserved mRNA Export Machinery Coupled to pre-mRNA Splicing

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Reed, Robin, Hurt, Ed·2002·Cell

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Abstract

Recent advances have led to a new understanding of how mRNAs are exported from the nucleus to the cytoplasm. This process requires a heterodimeric mRNA export receptor that is part of an elaborate machinery conserved from yeast to humans. Export of mRNAs is coupled to upstream steps in gene expression, such as pre-mRNA splicing, and to downstream events, including nonsense-mediated decay.

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Authors: Reed, R., & Hurt, E.
Affiliations: Harvard University (US)
Heidelberg University (DE)
Corresponding author: Reed, Robin
ORCID: Hurt, Ed
Venue: Cell
Publisher: Elsevier BV
Published: 2002-02
Volume: 108
Issue: 4
Pages: 523-531
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(02)00627-x
OpenAlex: W2155127403
Cited by: 400
References: 94
Citations by year: 2026: 3 · 2025: 3 · 2024: 9 · 2023: 4 · 2022: 4 · 2021: 15 · 2020: 11 · 2019: 6 · 2018: 5 · 2017: 11 · 2016: 15 · 2015: 9 · 2014: 9 · 2013: 14 · 2012: 17
FWCI: 3.53
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4184 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: mRNA export, pre-mRNA splicing, nuclear export, nonsense-mediated mRNA decay, gene expression regulation
MeSH terms: Animals, Fungal Proteins, Humans, Models, Biological, Nuclear Proteins, Ribonucleoproteins, RNA Precursors, RNA Splicing, RNA, Messenger, RNA-Binding Proteins, Spliceosomes, Active Transport, Cell Nucleus, Heterogeneous-Nuclear Ribonucleoproteins

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A Conserved mRNA Export Machinery Coupled to pre-mRNA Splicing

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