The DOI matches its Crossref record; 93 of the 94 references it cites were found in a registry or an index.
A Conserved mRNA Export Machinery Coupled to pre-mRNA Splicing
Open accessAbstract
Recent advances have led to a new understanding of how mRNAs are exported from the nucleus to the cytoplasm. This process requires a heterodimeric mRNA export receptor that is part of an elaborate machinery conserved from yeast to humans. Export of mRNAs is coupled to upstream steps in gene expression, such as pre-mRNA splicing, and to downstream events, including nonsense-mediated decay.
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“Intron element is generally positioned downstream of a promoter and enhances gene expression by improving mRNA stability and facilitating mRNA export to the cytoplasm [23].”
From Designing and optimizing AAV-mediated gene therapy for neurodegenerative diseases: from bench to bedside (2024) · cites this paper as [23]
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Citations
Cites
Transport Between the Cell Nucleus and the Cytoplasm
Görlich, D., & Kutay, U. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.607 · Cited by 2,006
The Yeast Nuclear Pore Complex
Rout, M. P., Aitchison, J. D., Suprapto, A., Hjertaas, K., Zhao, Y., & Chait, B. T. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.4.635 · Cited by 1,403
Nucleocytoplasmic transport: the soluble phase
Mattaj, I. W., & Englmeier, L. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.265 · Cited by 1,175
Integrating mRNA Processing with Transcription
Proudfoot, N. J., Furger, A., & Dye, M. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00617-7 · Cited by 1,084
Sorting out the complexity of SR protein functions
Graveley, B. R. (2000) · RNA · doi:10.1017/s1355838200000960 · Cited by 1,080
The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions
Hir, H. L., Izaurralde, E., Maquat, L. E., & Moore, M. J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.24.6860 · Cited by 970
Hir, H. L., Gatfield, D., Izaurralde, E., & Moore, M. J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4987 · Cited by 842
Transport of Proteins and RNAs in and out of the Nucleus
Nakielny, S., & Dreyfuss, G. (1999) · Cell · doi:10.1016/s0092-8674(00)81666-9 · Cited by 755
Lykke‐Andersen, J., Shu, M.-D., & STEITZ, J. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00214-2 · Cited by 579
RNA polymerase II and the integration of nuclear eventsPreprint
Hirose, Y., & Manley, J. L. (2000) · Genes & Development · doi:10.1101/gad.14.12.1415 · Cited by 577
Cited by
Sorted by citations
Mechanisms of Alternative Pre-Messenger RNA Splicing
Black, D. L. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161720 · Cited by 2,704
MicroRNA maturation: stepwise processing and subcellular localization
Lee, Y., Jeon, K., Lee, J., Kim, S., & Kim, V. N. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf476 · Cited by 2,572
Function of alternative splicing
Stamm, S., Ben‐Ari, S., Rafalska, I., Tang, Y., Zhang, Z., Toiber, D., Thanaraj, T. A., & Soreq, H. (2004) · Gene · doi:10.1016/j.gene.2004.10.022 · Cited by 1,398
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics
Maquat, L. E. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1310 · Cited by 1,214
Proteomic analysis of the mammalian nuclear pore complex
Cronshaw, J. M., Krutchinsky, A. N., Zhang, W., Chait, B. T., & Matunis, M. J. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200206106 · Cited by 977
Metadata
- Authors
- Reed, R., & Hurt, E.
- Affiliations
- Harvard University (US)
- Heidelberg University (DE)
- Corresponding author
- Reed, Robin
- ORCID
- Hurt, Ed
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 108
- Issue
- 4
- Pages
- 523-531
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2155127403
- Cited by
- 400
- References
- 94
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 9 · 2023: 4 · 2022: 4 · 2021: 15 · 2020: 11 · 2019: 6 · 2018: 5 · 2017: 11 · 2016: 15 · 2015: 9 · 2014: 9 · 2013: 14 · 2012: 17
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- mRNA export, pre-mRNA splicing, nuclear export, nonsense-mediated mRNA decay, gene expression regulation
- MeSH terms
- Animals, Fungal Proteins, Humans, Models, Biological, Nuclear Proteins, Ribonucleoproteins, RNA Precursors, RNA Splicing, RNA, Messenger, RNA-Binding Proteins, Spliceosomes, Active Transport, Cell Nucleus, Heterogeneous-Nuclear Ribonucleoproteins
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