Cited by 234Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathwaysAutophagy in Disease and Therapy

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Are ubiquitination pathways central to Parkinson’s disease?

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Giasson, Benoit I, Lee, Virginia M.-Y·2003·Cell

DOI 10.1016/s0092-8674(03)00509-9

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Abstract

Parkinson's disease (PD) is the most common neurodegenerative movement disorder. The major motor disabilities of PD are associated with the extensive loss of dopaminergic neurons in the substantia nigra pars compacta. The physiological changes and biochemical pathways involved in the selective demise of these neurons are still unclear. Recent studies have demonstrated that alterations or reductions in ubiquitin-mediated proteasome function can be causal of at least some forms of parkinsonism, and multiple lines of evidence suggest that this mechanism of protein degradation may play an important role in the etiology of PD.

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Authors: Giasson, B. I., & Lee, V. M.-Y.
Affiliations: University of Pennsylvania (US)
Corresponding author: Lee, Virginia M.-Y
ORCID: Giasson, Benoit I
Lee, Virginia M.-Y
Venue: Cell
Publisher: Elsevier BV
Published: 2003-07
Volume: 114
Issue: 1
Pages: 1-8
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(03)00509-9
OpenAlex: W2171114341
Cited by: 234
References: 38
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 8 · 2012: 14
FWCI: 4.72
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3669 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: Parkinson's disease, ubiquitination, ubiquitin-proteasome system, proteasome dysfunction, dopaminergic neuron loss, substantia nigra pars compacta, neurodegeneration, parkinsonism, protein degradation
MeSH terms: Animals, Cysteine Endopeptidases, Humans, Ligases, Multienzyme Complexes, Nerve Tissue Proteins, Neurons, Parkinson Disease, Substantia Nigra, Thiolester Hydrolases, Receptors, Endothelin, Ubiquitin, Drosophila Proteins, Ubiquitin Thiolesterase, Ubiquitin-Protein Ligases, Proteasome Endopeptidase Complex, Synucleins

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Are ubiquitination pathways central to Parkinson’s disease?

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