Cited by 415Ubiquitin and proteasome pathwaysMicrotubule and mitosis dynamicsGenomics and Chromatin Dynamics

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COP9 Signalosome

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Cope, Gregory A, Deshaies, Raymond J·2003·Cell

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Abstract

COP9 Signalosome (CSN) is a fascinating protein complex whose biochemical and physiological functions are only beginning to be understood. It is conserved throughout eukaryotes and is critical to the proper development of all multicellular organisms in which its function has been explored. Recent work suggests that CSN plays a key role in sustaining the activity of SCF and other cullin-based ubiquitin ligases, which may account for its essential roles in development. Here, we summarize what is known about CSN, and discuss hypotheses for how CSN promotes the activity of SCF ubiquitin ligases.

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Authors: Cope, G. A., & Deshaies, R. J.
Affiliations: California Institute of Technology (US)
Corresponding author: Deshaies, Raymond J
ORCID: Deshaies, Raymond J
Venue: Cell
Publisher: Elsevier BV
Published: 2003-09
Volume: 114
Issue: 6
Pages: 663-671
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(03)00722-0
OpenAlex: W1541556706
Cited by: 409
References: 58
Citations by year: 2026: 10 · 2025: 6 · 2024: 8 · 2023: 11 · 2022: 9 · 2021: 16 · 2020: 24 · 2019: 14 · 2018: 13 · 2017: 13 · 2016: 12 · 2015: 12 · 2014: 19 · 2013: 21 · 2012: 23
FWCI: 2.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3607 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: COP9 signalosome, SCF ubiquitin ligase, protein complexes, ubiquitination, multicellular development, eukaryotic evolution
MeSH terms: COP9 Signalosome Complex, Animals, Cell Differentiation, Cysteine Endopeptidases, Eukaryotic Cells, Humans, Multienzyme Complexes, Peptide Hydrolases, Peptide Synthases, Proteins, Ubiquitin, SKP Cullin F-Box Protein Ligases, Multiprotein Complexes, Proteasome Endopeptidase Complex

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COP9 Signalosome

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