The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
COP9 Signalosome
Open accessAbstract
COP9 Signalosome (CSN) is a fascinating protein complex whose biochemical and physiological functions are only beginning to be understood. It is conserved throughout eukaryotes and is critical to the proper development of all multicellular organisms in which its function has been explored. Recent work suggests that CSN plays a key role in sustaining the activity of SCF and other cullin-based ubiquitin ligases, which may account for its essential roles in development. Here, we summarize what is known about CSN, and discuss hypotheses for how CSN promotes the activity of SCF ubiquitin ligases.
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“Cullin-based ubiquitin ligase activity is stimulated by neddylation (i.e., NEDD8 conjugation) to cullin and downregulated by deneddylation mediated by the COP9 signalosome6,7.”
From Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide (2020) · cites this paper as [7]
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Cites
Auxin regulates SCFTIR1-dependent degradation of AUX/IAA proteins
Gray, W. M., Kepinski, S., Rouse, D. T., Leyser, O., & Estelle, M. A. (2001) · Nature · doi:10.1038/35104500 · Cited by 1,415
Targeted destabilization of HY5 during light-regulated development of Arabidopsis
Østerlund, M. T., Hardtke, C. S., Wei, N., & Deng, X. W. (2000) · Nature · doi:10.1038/35013076 · Cited by 1,363
SCF and Cullin/RING H2-Based Ubiquitin Ligases
Deshaies, R. J. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.435 · Cited by 1,238
Self-citationGroisman, R., Polanowska, J., Kuraoka, I., Sawada, J.-I., Saijo, M., Drapkin, R., Kisselev, A. F., Tanaka, K., & Nakatani, Y. (2003) · Cell · doi:10.1016/s0092-8674(03)00316-7 · Cited by 756
Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome
Lyapina, S., Cope, G. A., Shevchenko, A., Serino, G., Tsuge, T., Zhou, C., Wolf, D. A., Wei, N., Shevchenko, A., & Deshaies, R. J. (2001) · Science · doi:10.1126/science.1059780 · Cited by 699
Self-citationRole of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8 from Cul1
Cope, G. A., Suh, G. S. B., Aravind, L., Schwarz, S. E., Zipursky, S. L., Koonin, E. V., & Deshaies, R. J. (2002) · Science · doi:10.1126/science.1075901 · Cited by 682
Self-citationDegradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1
Tomoda, K., Kubota, Y., & Kato, J. (1999) · Nature · doi:10.1038/18230 · Cited by 632
Structure of a β-TrCP1-Skp1-β-Catenin Complex
Wu, G., Xu, G., Schulman, B. A., Jeffrey, P. D., Harper, J. W., & Pavletich, N. P. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00234-x · Cited by 612
The RAR1 Interactor SGT1, an Essential Component of R Gene-Triggered Disease Resistance
Azevedo, C., Sadanandom, A., Kitagawa, K., Freialdenhoven, A., Shirasu, K., & Schulze‐Lefert, P. (2002) · Science · doi:10.1126/science.1067554 · Cited by 611
Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1
Kleemann, R., Haußer, A., Geiger, G., Mischke, R., Burger‐Kentischer, A., Flieger, O., Johannes, F., Roger, T., Calandra, T., Kapurniotu, A., et al. (2000) · Nature · doi:10.1038/35041591 · Cited by 567
Cited by
Sorted by citations
RING Domain E3 Ubiquitin Ligases
Deshaies, R. J., & Joazeiro, C. A. P. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.101807.093809 · Cited by 2,679
Self-citationKobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224
Function and regulation of cullin–RING ubiquitin ligases
Petroski, M. D., & Deshaies, R. J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1547 · Cited by 2,148
Self-citationDefining the Human Deubiquitinating Enzyme Interaction Landscape
Sowa, M. E., Bennett, E. J., Gygi, S. P., & Harper, J. W. (2009) · Cell · doi:10.1016/j.cell.2009.04.042 · Cited by 1,523
Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex
Zhang, D. D., Lo, S., Cross, J. V., Templeton, D. J., & Hannink, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10941-10953.2004 · Cited by 1,284
Metadata
- Authors
- Cope, G. A., & Deshaies, R. J.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Deshaies, Raymond J
- ORCID
- Deshaies, Raymond J
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 114
- Issue
- 6
- Pages
- 663-671
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1541556706
- Cited by
- 409
- References
- 58
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 8 · 2023: 11 · 2022: 9 · 2021: 16 · 2020: 24 · 2019: 14 · 2018: 13 · 2017: 13 · 2016: 12 · 2015: 12 · 2014: 19 · 2013: 21 · 2012: 23
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- COP9 signalosome, SCF ubiquitin ligase, protein complexes, ubiquitination, multicellular development, eukaryotic evolution
- MeSH terms
- COP9 Signalosome Complex, Animals, Cell Differentiation, Cysteine Endopeptidases, Eukaryotic Cells, Humans, Multienzyme Complexes, Peptide Hydrolases, Peptide Synthases, Proteins, Ubiquitin, SKP Cullin F-Box Protein Ligases, Multiprotein Complexes, Proteasome Endopeptidase Complex
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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