Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins

The Pfam Protein Families Database

Bateman, A. G. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.276 · Cited by 14,062 · see citing works

Multiple sequence alignment with hierarchical clustering.

Corpet, F. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.22.10881 · Cited by 5,575 · see citing works

Rho GTPases and their effector proteins

Bishop, A. L., & Hall, A. (2000) · Biochemical Journal · doi:10.1042/bj3480241 · Cited by 2,040 · see citing works

The Pfam Protein Families Database

Bateman, A. G. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.263 · Cited by 1,253 · see citing works

S. typhimurium Encodes an Activator of Rho GTPases that Induces Membrane Ruffling and Nuclear Responses in Host Cells

Hardt, W., Chen, L., Schuebel, K. E., Bustelo, X. R., & Galán, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81442-7 · Cited by 811 · see citing works

Predicting coiled coils by use of pairwise residue correlations.

Berger, B., Wilson, D. B., Wolf, E., Tonchev, T., Milla, M. E., & Kim, P. S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8259 · Cited by 622 · see citing works

[30] Prediction and analysis of coiled-coil structures

Lupas, A. N. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)66032-7 · Cited by 575 · see citing works

CED-12/ELMO, a Novel Member of the CrkII/Dock180/Rac Pathway, Is Required for Phagocytosis and Cell Migration

Gumienny, T. L., Brugnera, E., Tosello-Trampont, A.-C., Kinchen, J. M., Haney, L. B., Nishiwaki, K., Walk, S. F., Nemergut, M. E., Macara, I. G., Francis, R., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00520-7 · Cited by 568 · see citing works

The Dbl family of oncogenes

Cerione, R. A., & Zheng, Y. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80068-8 · Cited by 492 · see citing works

Rho Guanine Dissociation Inhibitors

Olofsson, B. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(98)00063-1 · Cited by 491 · see citing works

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK

del Pozo, M. Á., Price, L., Alderson, N. B., Ren, X., & Schwartz, M. A. (2000) · The EMBO Journal · doi:10.1093/emboj/19.9.2008 · Cited by 452 · see citing works

Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

Fukui, Y., Hashimoto, O., Sanui, T., Oono, T., Koga, H., Abe, M., Inayoshi, A., Noda, M., Oike, M., Shirai, T., et al. (2001) · Nature · doi:10.1038/35090591 · Cited by 449 · see citing works

Activation of Rac1 by a Crk SH3-binding protein, DOCK180Preprint

Kiyokawa, E., Hashimoto, Y., Kobayashi, S., Sugimura, H., Kurata, T., & Matsuda, M. (1998) · Genes & Development · doi:10.1101/gad.12.21.3331 · Cited by 431 · see citing works

CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans

Reddien, P. W., & Horvitz, H. R. (2000) · Nature Cell Biology · doi:10.1038/35004000 · Cited by 414 · see citing works

C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180

Wu, Y., & Horvitz, H. R. (1998) · Nature · doi:10.1038/33163 · Cited by 365 · see citing works

GEFs: structural basis for their activation of small GTP-binding proteins

Cherfils, J., & Chardin, P. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01429-2 · Cited by 338 · see citing works

Effectors for the Rho GTPases

Aspenström, P. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80011-8 · Cited by 326 · see citing works

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

Hart, M. J., Eva, A., Zangrilli, D., Aaronson, S. A., Evans, T., Cerione, R. A., & Zheng, Y. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42313-1 · Cited by 315 · see citing works

A Role for P21-Activated Kinase in Endothelial Cell Migration

Kiosses, W. B., Daniels, R. H., Otey, C. A., Bokoch, G., & Schwartz, M. A. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.4.831 · Cited by 296 · see citing works

IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells

Nhieu, G. T. V., Caron, E., Hall, A., & Sansonetti, P. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.12.3249 · Cited by 252 · see citing works

Evidence That DOCK180 Up-regulates Signals from the CrkII-p130Cas Complex

Kiyokawa, E., Hashimoto, Y., Kurata, T., Sugimura, H., & Matsuda, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.38.24479 · Cited by 208 · see citing works

Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processesPreprint

Nolan, K. M., Barrett, K., Lu, Y., Hu, K.-Q., Vincent, S., & Settleman, J. E. (1998) · Genes & Development · doi:10.1101/gad.12.21.3337 · Cited by 201 · see citing works

Prediction of the Coding Sequences of Unidentified Human Genes. XIV. The Complete Sequences of 100 New cDNA Clones from Brain Which Code for Large Proteins in vitro

Kikuno, R. F. (1999) · DNA Research · doi:10.1093/dnares/6.3.197 · Cited by 194 · see citing works

Identification of a Novel Guanine Nucleotide Exchange Factor for the Rho GTPase

Hart, M. J., Sharma, S., elMasry, N., Qiu, R.-G., McCabe, P. C., Polakis, P. G., & Bollag, G. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.41.25452 · Cited by 161 · see citing works

Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras.

Khosravi‐Far, R., Chrzanowska‐Wodnicka, M., Solski, P. A., Eva, A., Burridge, K., & Der, C. J. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.6848 · Cited by 136 · see citing works

A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm

Keep, N. H., Barnes, M., Barsukov, I., Badii, R., Lian, L., Segal, A. W., Moody, P. C. E., & Roberts, G. C. K. (1997) · Structure · doi:10.1016/s0969-2126(97)00218-9 · Cited by 116 · see citing works

Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins

Nishihara, H., Kobayashi, S., Hashimoto, Y., Ohba, F., Mochizuki, N., Kurata, T., Nagashima, K., & Matsuda, M. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(99)00133-0 · Cited by 100 · see citing works

Plant GTPases: the Rhos in bloom

Valster, A. H., Hepler, P. K., & Chernoff, J. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01728-1 · Cited by 94 · see citing works

Distinct migration patterns of naive and effector CD8 T cells in the spleen: correlation with CCR7 receptor expression and chemokine reactivity

Potsch, C., Voehringer, D., & Pircher, H. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199911)29:11 · Cited by 92 · see citing works

Biochemical Analysis of SopE from Salmonella typhimurium, a Highly Efficient Guanosine Nucleotide Exchange Factor for RhoGTPases

Rudolph, M. G., Weise, C., Mirold, S., Hillenbrand, B., Bader, B., Wittinghofer, A., & Hardt, W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30501 · Cited by 88 · see citing works

Rho and Rac Take Center Stage

Burridge, K., & Wennerberg, K. (2004) · Cell · doi:10.1016/s0092-8674(04)00003-0 · Cited by 1,790 · see citing works

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

Rossman, K. L., Der, C. J., & Sondek, J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1587 · Cited by 1,697 · see citing works

Cell migration: Rho GTPases lead the way

Raftopoulou, M., & Hall, A. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.06.003 · Cited by 1,444 · see citing works

Focal adhesion kinase: the first ten years

Parsons, J. T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00373 · Cited by 1,364 · see citing works

Engulfment of apoptotic cells: signals for a good meal

Ravichandran, K. S., & Lorenz, U. M. (2007) · Nature reviews. Immunology · doi:10.1038/nri2214 · Cited by 634 · see citing works

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity

Côté, J., & Vuori, K. (2002) · Journal of Cell Science · doi:10.1242/jcs.00219 · Cited by 412 · see citing works

GEF what? Dock180 and related proteins help Rac to polarize cells in new ways

Côté, J., & Vuori, K. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.05.001 · Cited by 322 · see citing works

SPATIAL CONTROL OF CELL EXPANSION BY THE PLANT CYTOSKELETON

Smith, L. G., & Oppenheimer, D. G. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.122303.114901 · Cited by 291 · see citing works

Signalling mechanisms mediating neuronal responses to guidance cues

Guan, K., & Rao, Y. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1254 · Cited by 287 · see citing works

A new family of RhoGEFs activates the Rop molecular switch in plants

Berken, A., Thomas, C., & Wittinghofer, A. (2005) · Nature · doi:10.1038/nature03883 · Cited by 281 · see citing works

CZH proteins: a new family of Rho-GEFs

Meller, N., Merlot, S., & Guda, C. (2005) · Journal of Cell Science · doi:10.1242/jcs.02671 · Cited by 273 · see citing works

Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways

Merlot, S., & Firtel, R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00703 · Cited by 273 · see citing works

DOCK4, a GTPase activator, is disrupted during tumorigenesis.

Yajnik, V., Paulding, C., Sordella, R., McClatchey, A. I., Saito, M., Wahrer, D. C. R., Reynolds, P., Bell, D. W., Lake, R., van den Heuvel, S., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00155-7 · Cited by 230 · see citing works

Dock180 and ELMO1 Proteins Cooperate to Promote Evolutionarily Conserved Rac-dependent Cell Migration

Grimsley, C. M., Kinchen, J. M., Tosello-Trampont, A.-C., Brugnera, E., Haney, L. B., Lu, M., Chen, Q., Klingele, D., Hengartner, M. O., & Ravichandran, K. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307087200 · Cited by 224 · see citing works

A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling

Côté, J., Motoyama, A. B., Bush, J., & Vuori, K. (2005) · Nature Cell Biology · doi:10.1038/ncb1280 · Cited by 222 · see citing works

Dock-family exchange factors in cell migration and disease

Gadea, G., & Blangy, A. (2014) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2014.06.003 · Cited by 217 · see citing works

The Rac Activator DOCK7 Regulates Neuronal Polarity through Local Phosphorylation of Stathmin/Op18

Watabe-Uchida, M., John, K. A., Janas, J. A., Newey, S. E., & Van Aelst, L. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.020 · Cited by 208 · see citing works

DOCK10-Mediated Cdc42 Activation Is Necessary for Amoeboid Invasion of Melanoma Cells

Gadéa, G., Sanz‐Moreno, V., Self, A. J., Godi, A., & Marshall, C. J. (2008) · Current Biology · doi:10.1016/j.cub.2008.08.053 · Cited by 194 · see citing works

Localized Cdc42 Activation, Detected Using a Novel Assay, Mediates Microtubule Organizing Center Positioning in Endothelial Cells in Response to Fluid Shear Stress

Tzima, E., Kiosses, W. B., del Pozo, M. Á., & Schwartz, M. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301179200 · Cited by 183 · see citing works

The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo

Laurin, M., Fradet, N., Blangy, A., Hall, A., Vuori, K., & Côté, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805546105 · Cited by 167 · see citing works

Activation of Rac1 by RhoG regulates cell migration

Katoh, H., Hiramoto, K., & Negishi, M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02720 · Cited by 171 · see citing works

A SPIKE1 signaling complex controls actin-dependent cell morphogenesis through the heteromeric WAVE and ARP2/3 complexes

Basu, D., Le, J., Zakharova, T., Mallery, E. L., & Szymanski, D. B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710294105 · Cited by 164 · see citing works

ROP/RAC GTPase: an old new master regulator for plant signaling

Gu, Y., Wang, Z., & Yang, Z. (2004) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2004.07.006 · Cited by 160 · see citing works

Insights into the biological functions of Dock family guanine nucleotide exchange factors

Laurin, M., & Côté, J.-F. (2014) · Genes & Development · doi:10.1101/gad.236349.113 · Cited by 160 · see citing works

Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism

Hiramoto‐Yamaki, N., Takeuchi, S., Ueda, S., Harada, K., Fujimoto, S., Negishi, M., & Katoh, H. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201005141 · Cited by 144 · see citing works

New insights into Rho signaling from plant ROP/Rac GTPases

Craddock, C. P., Lavagi, I., & Yang, Z. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.05.002 · Cited by 144 · see citing works

P-Rex1 Is a Primary Rac2 Guanine Nucleotide Exchange Factor in Mouse Neutrophils

Dong, X., Mo, Z., Bokoch, G., Guo, C., Li, Z., & Wu, D. (2005) · Current Biology · doi:10.1016/j.cub.2005.09.014 · Cited by 135 · see citing works

Cellular signaling for activation of Rho GTPase Cdc42

Sinha, S., & Yang, W. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.05.002 · Cited by 133 · see citing works

Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR

Sasaki, A. T., & Firtel, R. (2006) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2006.04.007 · Cited by 131 · see citing works

PH domain of ELMO functions in trans to regulate Rac activation via Dock180

Lu, M., Kinchen, J. M., Rossman, K. L., Grimsley‐Myers, C. M., deBakker, C. D., Brugnera, E., Tosello‐Trampont, A., Haney, L. B., Klingele, D., Sondek, J., et al. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb800 · Cited by 130 · see citing works

Activation of Ras Signaling Pathway by 8-Oxoguanine DNA Glycosylase Bound to Its Excision Product, 8-Oxoguanine

Boldogh, I. R., Hajas, G., Aguilera-Aguirre, L., Hegde, M. L., Radak, Z. O., Bácsi, A., Sur, S. A., Hazra, T. K., & MITRA, S. P. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.c112.364620 · Cited by 130 · see citing works

ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration

Yamauchi, J., Miyamoto, Y., Chan, J. R., & Tanoue, A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709033 · Cited by 131 · see citing works

In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion

Hirata, E., Yukinaga, H., Kamioka, Y., Arakawa, Y., Miyamoto, S., Okada, T., Sahai, E. A., & Matsuda, M. (2012) · Journal of Cell Science · doi:10.1242/jcs.089995 · Cited by 127 · see citing works

Activation of Rho GTPases by DOCK Exchange Factors Is Mediated by a Nucleotide Sensor

Yang, J., Zhang, Z., Roe, S. M., Marshall, C. J., & Barford, D. (2009) · Science · doi:10.1126/science.1174468 · Cited by 123 · see citing works

Functional coordination of alternative splicing in the mammalian central nervous system

Fagnani, M., Barash, Y., Ip, J. Y., Misquitta, C., Pan, Q., Saltzman, A. L., Shai, O., Lee, L., Rozenhek, A., Mohammad, N., et al. (2007) · Genome Biology · doi:10.1186/gb-2007-8-6-r108 · Cited by 120 · see citing works

Genetic and Environmental Risk Factors for Keratoconus

Lucas, S. E. M., & Burdon, K. P. (2020) · Annual Review of Vision Science · doi:10.1146/annurev-vision-121219-081723 · Cited by 114 · see citing works

Mouse Proteome AnalysisPreprint

Kanapin, A. A., Batalov, S., Davis, M. J., Gough, J., Grimmond, S. M., Kawaji, H., Magrane, M., Matsuda, H., Schönbach, C., Teasdale, R. D., et al. (2003) · Genome Research · doi:10.1101/gr.978703 · Cited by 113 · see citing works

Isolation and characterisation of DOCK8, a member of the DOCK180‐related regulators of cell morphology

Ruusala, A., & Aspenström, P. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.095 · Cited by 110 · see citing works

Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling

Li, X., Gao, X., Liu, G., Xiong, W., Wu, J. Y., & Rao, Y. (2007) · Nature Neuroscience · doi:10.1038/nn2022 · Cited by 108 · see citing works

A Direct Interaction between Cdc42 and Vesicle-associated Membrane Protein 2 Regulates SNARE-dependent Insulin Exocytosis*

Nevins, A. K., & Thurmond, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409528200 · Cited by 101 · see citing works

A Steric-Inhibition Model for Regulation of Nucleotide Exchange via the Dock180 Family of GEFs

Lu, M., Kinchen, J. M., Rossman, K. L., Grimsley, C., Hall, M., Sondek, J., Hengartner, M. O., Yajnik, V., & Ravichandran, K. S. (2005) · Current Biology · doi:10.1016/j.cub.2005.01.050 · Cited by 102 · see citing works

Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression

Ensign, S. P. F., Mathews, I. T., Symons, M. H., Berens, M. E., & Tran, N. L. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00241 · Cited by 99 · see citing works

Molecular Basis for Rho GTPase Signaling Specificity

Karnoub, A. E., Symons, M. H., Campbell, S. L., & Der, C. J. (2004) · Breast Cancer Research and Treatment · doi:10.1023/b:brea.0000018427.84929.5c · Cited by 99 · see citing works

Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (DOCK) Nucleotide Exchange Factors

Kulkarni, K., Yang, J., Zhang, Z., & Barford, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.236455 · Cited by 97 · see citing works

Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth

Miyamoto, Y., Yamauchi, J., Sanbe, A., & Tanoue, A. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.11.017 · Cited by 95 · see citing works

Dock4 is regulated by RhoG and promotes Rac-dependent cell migration

Hiramoto, K., Negishi, M., & Katoh, H. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.09.006 · Cited by 92 · see citing works

A Rac/Cdc42-specific Exchange Factor, GEFT, Induces Cell Proliferation, Transformation, and Migration

Guo, X., Stafford, L. J., Bryan, B. A., Xia, C., Ma, W., Wu, X., Liu, D., Songyang, Z., & Liu, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208896200 · Cited by 88 · see citing works

Phosphorylation of IQGAP1 Modulates Its Binding to Cdc42, Revealing a New Type of Rho-GTPase Regulator

Grohmanova, K., Schlaepfer, D., Heß, D., Gutierrez, P., Beck, M., & Kroschewski, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408113200 · Cited by 87 · see citing works

Dock180–ELMO Cooperation in Rac Activation

Lu, M., & Ravichandran, K. S. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)06028-9 · Cited by 84 · see citing works

Cellular signaling of Dock family proteins in neural function

Miyamoto, Y., & Yamauchi, J. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.09.036 · Cited by 85 · see citing works

Blockade of Inflammatory Responses by a Small-Molecule Inhibitor of the Rac Activator DOCK2

Nishikimi, A., Uruno, T., Duan, X., Cao, Q., Okamura, Y., Saitoh, T., Saito, N., Sakaoka, S., Du, Y., Suenaga, A., et al. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.03.008 · Cited by 83 · see citing works

Immune regulatory functions of DOCK family proteins in health and disease

Nishikimi, A., Kukimoto-Niino, M., Yokoyama, S., & Fukui, Y. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.07.024 · Cited by 80 · see citing works

RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation

Calvo, F., Sanz‐Moreno, V., Agudo‐Ibáñez, L., Wållberg, F., Sahai, E. A., Marshall, C. J., & Crespo, P. (2011) · Nature Cell Biology · doi:10.1038/ncb2271 · Cited by 80 · see citing works

Rho GAPs and GEFs

van Buul, J. D., Geerts, D., & Huveneers, S. (2014) · Cell Adhesion & Migration · doi:10.4161/cam.27599 · Cited by 79 · see citing works

Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation

Hussain, N. K., Thomas, G. M., Luo, J., & Huganir, R. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518382112 · Cited by 71 · see citing works

The Helix–Loop–Helix Factors Id3 and E47 Are Novel Regulators of Adiponectin

Doran, A. C., Meller, N., Cutchins, A. C., Deliri, H., Slayton, R. P., Oldham, S. N., Kim, J. B., Keller, S. R., & McNamara, C. A. (2008) · Circulation Research · doi:10.1161/circresaha.108.175893 · Cited by 73 · see citing works

Axl Phosphorylates Elmo Scaffold Proteins To Promote Rac Activation and Cell Invasion

Abu-Thuraia, A., Gauthier, R., Chidiac, R., Fukui, Y., Screaton, R. A., Gratton, J., & Côté, J. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00764-14 · Cited by 73 · see citing works

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms

Hanawa-Suetsugu, K., Kukimoto-Niino, M., Mishima-Tsumagari, C., Akasaka, R., Ohsawa, N., Sekine, S.-I., Ito, T., Tochio, N., Koshiba, S., Kigawa, T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113512109 · Cited by 70 · see citing works

Zizimin2: a novel, DOCK180‐related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes

Nishikimi, A., Meller, N., Uekawa, N., Isobe, K.-I., Schwartz, M. A., & Maruyama, M. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.01.006 · Cited by 70 · see citing works

PTP-PEST Couples Membrane Protrusion and Tail Retraction via VAV2 and p190RhoGAP

Sastry, S. K., Rajfur, Z., Liu, B. P., Côté, J., Tremblay, M. L., & Burridge, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600897200 · Cited by 67 · see citing works

Structural Basis of Membrane Targeting by the Dock180 Family of Rho Family Guanine Exchange Factors (Rho-GEFs)

Premkumar, L., Bobkov, A. A., Patel, M., Jaroszewski, L., Bankston, L. A., Stec, B., Vuori, K., Côté, J.-F., & Liddington, R. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.102517 · Cited by 68 · see citing works

Comprehensive analysis of the long noncoding RNA HOXA11-AS gene interaction regulatory network in NSCLC cells

Zhang, Y., He, R., Dang, Y., Zhang, X., Wang, X., Huang, S., Huang, W., Jiang, M., Gan, X., Xie, Y., et al. (2016) · Cancer Cell International · doi:10.1186/s12935-016-0366-6 · Cited by 67 · see citing works

An Evolutionarily Conserved Autoinhibitory Molecular Switch in ELMO Proteins Regulates Rac Signaling

Patel, M., Margaron, Y., Fradet, N., Yang, Q., Wilkes, B. C., Bouvier, M., Hofmann, K., & Côté, J. (2010) · Current Biology · doi:10.1016/j.cub.2010.10.028 · Cited by 65 · see citing works

Dock4 regulates dendritic development in hippocampal neurons.

Ueda, S., Fujimoto, S., Hiramoto, K., Negishi, M., & Katoh, H. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21763 · Cited by 61 · see citing works

Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines

Penzes, P., & Cahill, M. E. (2012) · Cytoskeleton · doi:10.1002/cm.21015 · Cited by 57 · see citing works

Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state

Chang, L., Yang, J., Jo, C. H., Boland, A., Zhang, Z., McLaughlin, S. H., Abu-Thuraia, A., Killoran, R. C., Smith, M. J., Côté, J.-F., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17271-9 · Cited by 59 · see citing works

Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites

Ueda, S., Kataoka, T., & Satoh, T. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.01.007 · Cited by 57 · see citing works

Proteomic analysis for inhibitory effect of chitosan oligosaccharides on 3T3‐L1 adipocyte differentiation

Rahman, M. A., Kumar, S. G., Kim, S. W., Hwang, H. J., Baek, Y. M., Lee, S. H., Hwang, H. S., Shon, Y. H., Nam, K. S., & Yun, J. W. (2008) · PROTEOMICS · doi:10.1002/pmic.200700888 · Cited by 56 · see citing works

Identification of a DOCK180-related Guanine Nucleotide Exchange Factor That Is Capable of Mediating a Positive Feedback Activation of Cdc42

Lin, Q., Yang, W., Baird, D., Feng, Q., & Cerione, R. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606248200 · Cited by 56 · see citing works

The RhoG/ELMO1/Dock180 Signaling Module Is Required for Spine Morphogenesis in Hippocampal Neurons

Kim, J., Oh, M. H., Bernard, L. P., Macara, I. G., & Zhang, H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.268029 · Cited by 53 · see citing works

Id3 Is a Novel Atheroprotective Factor Containing a Functionally Significant Single-Nucleotide Polymorphism Associated With Intima–Media Thickness in Humans

Doran, A. C., Lehtinen, A. B., Meller, N., Lipinski, M. J., Slayton, R. P., Oldham, S. N., Skaflen, M. D., Yeboah, J., Rich, S. S., Bowden, D. W., et al. (2010) · Circulation Research · doi:10.1161/circresaha.109.210294 · Cited by 52 · see citing works

Activation of Rac1 by the Guanine Nucleotide Exchange Factor Dck1 Is Required for Invasive Filamentous Growth in the PathogenCandida albicans

Hope, H., Bogliolo, S., Arkowitz, R. A., & Bassilana, M. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1272 · Cited by 51 · see citing works

Phosphatidic Acid-dependent Recruitment and Function of the Rac Activator DOCK1 during Dorsal Ruffle Formation

Sanematsu, F., Nishikimi, A., Watanabe, M., Hongu, T., Tanaka, Y., Kanaho, Y., Côté, J., & Fukui, Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.410423 · Cited by 51 · see citing works

Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer

Takahashi, K., Kohno, T., Ajima, R., Sasaki, H., Minna, J. D., Fujiwara, T., Tanaka, N., & Yokota, J. (2006) · International Journal of Oncology · doi:10.3892/ijo.28.2.321 · Cited by 50 · see citing works

Opening up on ELMO regulation

Patel, M., Pelletier, A., & Côté, J. (2011) · Small GTPases · doi:10.4161/sgtp.2.5.17716 · Cited by 50 · see citing works

Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells

Radvák, P., Repic, M., Švastová, E., Takáčová, M., Csáderová, L., Strnad, H., Pastorek, J., Pastoreková, S., & Kopáček, J. (2013) · Oncology Reports · doi:10.3892/or.2013.2226 · Cited by 50 · see citing works

Regulation of Immature Dendritic Cell Migration by RhoA Guanine Nucleotide Exchange Factor Arhgef5

Wang, Z., Kumamoto, Y., Wang, P., Gan, X., Lehmann, D. M., Smrcka, A. V., Cohn, L. E., Iwasaki, A., Li, L., & Wu, D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.047282 · Cited by 50 · see citing works

Mastoparan-Induced Insulin Secretion from Insulin-Secreting βTC3 and INS-1 Cells: Evidence for Its Regulation by Rho Subfamily of G Proteins

Amin, R., Chen, H.-Q., Veluthakal, R., Silver, R. B., Li, J., Li, G., & Kowluru, A. (2003) · Endocrinology · doi:10.1210/en.2003-0106 · Cited by 49 · see citing works

DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation

Ogawa, K., Tanaka, Y., Uruno, T., Duan, X., Harada, Y., Sanematsu, F., Yamamura, K., Terasawa, M., Nishikimi, A., Côté, J., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131926 · Cited by 49 · see citing works

Dock GEFs and their therapeutic potential: Neuroprotection and axon regeneration

Namekata, K., Kimura, A., Kawamura, K., Harada, C., & Harada, T. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.06.005 · Cited by 57 · see citing works

Identification of novel Smad2 and Smad3 associated proteins in response to TGF‐β1

Brown, K. A., Ham, A. L., Clark, C., Meller, N., Law, B. K., Chytil, A. M., Cheng, N., Pietenpol, J. A., & Moses, H. L. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21860 · Cited by 47 · see citing works

Dock4 forms a complex with SH3YL1 and regulates cancer cell migration

Kobayashi, M., Harada, K., Negishi, M., & Katoh, H. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.01.027 · Cited by 46 · see citing works

Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes

Yelo, E., Bernardo, M. V., Gimeno, L., Alcaraz-García, M. J., Majado, M. J., & Parrado, A. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.04.003 · Cited by 46 · see citing works

In Vitro Guanine Nucleotide Exchange Activity of DHR‐2/DOCKER/CZH2 Domains

Côté, J., & Vuori, K. (2006) · Methods in Enzymology · doi:10.1016/s0076-6879(06)06004-6 · Cited by 45 · see citing works

Regulation of dendrite growth by the Cdc42 activator Zizimin1/Dock9 in hippocampal neurons

Kuramoto, K., Negishi, M., & Katoh, H. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.21997 · Cited by 46 · see citing works

The CDM Superfamily Protein MBC Directs Myoblast Fusion through a Mechanism That Requires Phosphatidylinositol 3,4,5-Triphosphate Binding but Is Independent of Direct Interaction with DCrk

Balagopalan, L., Chen, M.-H., Geisbrecht, E. R., & Abmayr, S. M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00016-06 · Cited by 40 · see citing works

Dedicator of Cytokinesis 2 in Cell Signaling Regulation and Disease Development

Guo, X., & Chen, S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25512 · Cited by 40 · see citing works

Identification of a Core Module for Bone Mineral Density through the Integration of a Co-expression Network and GWAS Data

Sabik, O. L., Calabrese, G. M., Taleghani, E., Ackert‐Bicknell, C. L., & Farber, C. R. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108145 · Cited by 37 · see citing works

Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule

Ferrandez, Y., Zhang, W., Peurois, F., Akendengué, L., Blangy, A., Zeghouf, M., & Cherfils, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-13619-2 · Cited by 37 · see citing works

Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells

Ruiz-Lafuente, N., Alcaraz-García, M.-J., García-Serna, A.-M., Sebastián-Ruiz, S., Moya-Quiles, M.-R., García-Alonso, A.-M., & Parrado, A. (2015) · Biology Open · doi:10.1242/bio.20149050 · Cited by 37 · see citing works

Erk and PI3K temporally coordinate different modes of actin-based motility during embryonic wound healing

Li, J., Zhang, S., Soto, X., Woolner, S., & Amaya, E. (2013) · Journal of Cell Science · doi:10.1242/jcs.133421 · Cited by 36 · see citing works

Specific Recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 Guanine Nucleotide Exchange Factors

Kwofie, M. A., & Skowronski, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705170200 · Cited by 36 · see citing works

Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation

Tachibana, M., Kiyokawa, E., Hara, S., Iemura, S.-I., Natsume, T., Manabe, T., & Matsuda, M. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.12.005 · Cited by 34 · see citing works

Sequence variation in DOCK9 and heterogeneity in bipolar disorder

Detera‐Wadleigh, S. D., Liu, C., Maheshwari, M., Cardona, I., Corona, W., Akula, N., Steele, C. J. M., Badner, J. A., Kundu, M., Kassem, L., et al. (2007) · Psychiatric Genetics · doi:10.1097/ypg.0b013e328133f352 · Cited by 36 · see citing works

Structural biology of DOCK‐family guanine nucleotide exchange factors

Boland, A., Côté, J., & Barford, D. (2022) · FEBS Letters · doi:10.1002/1873-3468.14523 · Cited by 34 · see citing works

Dimerization of DOCK2 Is Essential for DOCK2-Mediated Rac Activation and Lymphocyte Migration

Terasawa, M., Uruno, T., Mori, S., Kukimoto‐Niino, M., Nishikimi, A., Sanematsu, F., Tanaka, Y., Yokoyama, S., & Fukui, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046277 · Cited by 30 · see citing works

Expression of Trio, a member of the Dbl family of Rho GEFs in the developing rat brain

Ma, X., Huang, J., Eipper, B. A., & Mains, R. E. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20404 · Cited by 32 · see citing works

The Novel Cdc42 Guanine Nucleotide Exchange Factor, Zizimin1, Dimerizes via the Cdc42-binding CZH2 Domain

Meller, N., Irani-Tehrani, M., Ratnikov, B. I., Paschal, B. M., & Schwartz, M. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404535200 · Cited by 32 · see citing works

Amino Acids of the Bacterial Toxin SopE Involved in G Nucleotide Exchange on Cdc42

Schlumberger, M. C., Friebel, A., Buchwald, G., Scheffzek, K., Wittinghofer, A., & Hardt, W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302475200 · Cited by 31 · see citing works

The DHR1 Domain of DOCK180 Binds to SNX5 and Regulates Cation-independent Mannose 6-phosphate Receptor Transport

Hara, S., Kiyokawa, E., Iemura, S.-I., Natsume, T., Wassmer, T., Cullen, P. J., Hiai, H., & Matsuda, M. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-03-0314 · Cited by 31 · see citing works

A New Turn-on for the Rho Family

(2002) · Science Signaling · doi:10.1126/scisignal.1492002tw332

The Novel Cdc42 Guanine Nucleotide Exchange Factor, Zizimin1, Dimerizes via the Cdc42-binding CZH2 Domain

Meller, N., Irani-Tehrani, M., Ratnikov, B. I., Paschal, B. M., & Schwartz, M. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404535200 · Cited by 32 · see citing works

CZH proteins: a new family of Rho-GEFs

Meller, N., Merlot, S., & Guda, C. (2005) · Journal of Cell Science · doi:10.1242/jcs.02671 · Cited by 273 · see citing works

Function of the N-terminus of zizimin1: autoinhibition and membrane targeting

Meller, N., Westbrook, M. J., Shannon, J. D., Guda, C., & Schwartz, M. A. (2007) · Biochemical Journal · doi:10.1042/bj20071263 · Cited by 28 · see citing works

Identification of a DOCK180-related Guanine Nucleotide Exchange Factor That Is Capable of Mediating a Positive Feedback Activation of Cdc42

Lin, Q., Yang, W., Baird, D., Feng, Q., & Cerione, R. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606248200 · Cited by 56 · see citing works