The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant mice
Abstract
The gene for mouse myelin basic protein (MBP) was mapped to chromosome 18 by hybridization of cloned MBP probes to DNA from hamster-mouse hybrid cell lines, showing it to be linked to the shiverer mutation which causes abnormal CNS myelination. Genomic blotting experiments show that in the mutants five of six exons which constitute the wild-type gene have been deleted. In shiverer brains the steady state level of transcripts that initiate correctly at the 5' end of the remaining exon 1 is reduced 16-fold. These RNAs are not spliced correctly and are not efficiently polyadenylated. It is proposed that the partial deletion of the MBP gene is an important part of the shiverer lesion.
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“Indeed, diffusion anisotropy is present even when compact myelin is completely absent, although it is significantly reduced (Roach et al., 1985; Watanabe et al., 2010).”
From The role of myelination in measures of white matter integrity: Combination of diffusion tensor imaging and two-photon microscopy of CLARITY intact brains (2017) · cites this paper as Roach et al., 1985
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Metadata
- Authors
- ROACH, A., TAKAHASHI, N., PRAVTCHEVA, D., RUDDLE, F., & HOOD, L.
- Affiliations
- California Institute of Technology (US)
- Yale University (US)
- ORCID
- HOOD, L
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1985-08
- Volume
- 42
- Issue
- 1
- Pages
- 149-155
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2151814085
- Cited by
- 336
- References
- 32
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 13 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 3
- FWCI
- 21.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- myelin basic protein, chromosome 18, gene mapping, partial gene deletion, CNS myelination, alternative splicing, transcription initiation, polyadenylation, exon deletion
- MeSH terms
- Animals, Base Sequence, Brain, Chromosome Deletion, Chromosome Mapping, Myelin Basic Protein, Genes, Genetic Linkage, Mice, Neurologic Mutants, Mutation, Poly A, RNA Splicing, RNA, Messenger, Transcription, Genetic, Mice
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