Cited by 470Growth Hormone and Insulin-like Growth FactorsDiabetes, Cardiovascular Risks, and LipoproteinsBirth, Development, and Health

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Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study

Sandhu, Manjinder S, Heald, Adrian H, Gibson, J Martin, Cruickshank, J Kennedy, Dunger, David B, Wareham, Nicholas J·2002·The Lancet

DOI 10.1016/s0140-6736(02)08655-5

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Abstract

Background Results of experimental and clinical studies suggest that insulin-like growth factor-I (IGF-I) and IGF binding protein-1 (IGFBP-1) could be important determinants of glucose homoeostasis. However, experimental models might also reflect compensatory and adaptive metabolic processes. We therefore prospectively examined the associations between circulating concentrations of IGF-I and IGFBP-1 and development of glucose tolerance.Methods Participants in this cohort study were a random sample of 615 normoglycaemic men and women aged 45-65 years. Participants underwent oral glucose tolerance testing based on WHO definitions and criteria in 1990-92 and 1994-96. At the baseline visit, we measured serum concentrations of IGF-I and IGFBP-1, and assessed the relation between these peptides and subsequent glucose intolerance.Findings At 4.5 years of follow-up, 51 (8%) of 615 participants developed impaired glucose tolerance or type-2 diabetes. After adjustment for correlates of IGF-I and risk factors for glucose intolerance, the odds ratio for risk of impaired glucose tolerance or type-2 diabetes for participants with IGF-I concentrations above the median (> or = 152 microg/L) compared with those with concentrations below the median (<152 microg/L) was 0.50 (0.26-0.95). Consistent with this finding, IGF-I also showed a significant inverse association with subsequent 2-h glucose concentrations, which was independent of correlates of IGF-I and risk factors for glucose tolerance (p for linear trend=0.026). We also found that this inverse association was independently modified by IGFBP-1 (p for interaction=0.011).Interpretation These data show that circulating IGF-I and its interaction with IGFBP-1 could be important determinants of glucose homoeostasis and provide further evidence for the possible protective role of IGF-I against development of glucose intolerance.

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Authors: Sandhu, M. S., Heald, A. H., Gibson, J. M., Cruickshank, J. K., Dunger, D. B., & Wareham, N. J.
Affiliations: University of Cambridge (GB)
University of Manchester (GB)
Corresponding author: Wareham, Nicholas J
ORCID: Sandhu, Manjinder S
Heald, Adrian H
Cruickshank, J Kennedy
Dunger, David B
Wareham, Nicholas J
Venue: The Lancet
Publisher: Elsevier BV
Published: 2002-05
Volume: 359
Issue: 9319
Pages: 1740-1745
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(02)08655-5
OpenAlex: W2140997600
Cited by: 470
References: 33
Citations by year: 2026: 3 · 2025: 10 · 2024: 11 · 2023: 13 · 2022: 18 · 2021: 15 · 2020: 17 · 2019: 15 · 2018: 18 · 2017: 18 · 2016: 17 · 2015: 14 · 2014: 19 · 2013: 11 · 2012: 28
FWCI: 15.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords: insulin-like growth factor I, IGF-binding protein-1, impaired glucose tolerance, type 2 diabetes, glucose homeostasis, 2-hour plasma glucose, middle-aged adults
MeSH terms: Aged, Blood Glucose, Fasting, Female, Homeostasis, Humans, Insulin-Like Growth Factor I, Male, Middle Aged, Prospective Studies, Glucose Intolerance, Insulin-Like Growth Factor Binding Protein 1

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Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study

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