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Cited by 56Growth Hormone and Insulin-like Growth FactorsDiet, Metabolism, and DiseaseFood composition and properties

Glycemic load effect on fasting and post-prandial serum glucose, insulin, IGF-1 and IGFBP-3 in a randomized, controlled feeding study

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Runchey, S S, Pollak, M N, Valsta, L M, Coronado, G D, Schwarz, Y, Breymeyer, K L, Wang, C, Wang, C-Y +2 more·2012·European Journal of Clinical Nutrition
DOI 10.1038/ejcn.2012.107PMC PMC3463643
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Abstract

Background/objectives The effect of a low glycemic load (GL) diet on insulin-like growth factor-1 (IGF-1) concentration is still unknown but may contribute to lower chronic disease risk. We aimed to assess the impact of GL on concentrations of IGF-1 and IGF-binding protein-3 (IGFBP-3). Subjects/methods We conducted a randomized, controlled crossover feeding trial in 84 overweight obese and normal weight healthy individuals using two 28-day weight-maintaining high- and low-GL diets. Measures were fasting and post-prandial concentrations of insulin, glucose, IGF-1 and IGFBP-3. In all 80 participants completed the study and 20 participants completed post-prandial testing by consuming a test breakfast at the end of each feeding period. We used paired t-tests for diet component and linear mixed models for biomarker analyses. Results The 28-day low-GL diet led to 4% lower fasting concentrations of IGF-1 (10.6 ng/ml, P=0.04) and a 4% lower ratio of IGF-1/IGFBP-3 (0.24, P=0.01) compared with the high-GL diet. The low-GL test breakfast led to 43% and 27% lower mean post-prandial glucose and insulin responses, respectively; mean incremental areas under the curve for glucose and insulin, respectively, were 64.3±21.8 (mmol/l/240 min; P<0.01) and 2253±539 (μU/ml/240 min; P<0.01) lower following the low- compared with the high-GL test meal. There was no effect of GL on mean homeostasis model assessment for insulin resistance or on mean integrated post-prandial concentrations of glucose-adjusted insulin, IGF-1 or IGFBP-3. We did not observe modification of the dietary effect by adiposity. Conclusions Low-GL diets resulted in 43% and 27% lower post-prandial responses of glucose and insulin, respectively, and modestly lower fasting IGF-1 concentrations. Further intervention studies are needed to weigh the impact of dietary GL on risk for chronic disease.

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  • In a 2-year randomized controlled trial in postmenopausal women, high whey consumption resulted in higher serum IGF-1 levels, 7.3% at 1 year and 8% at 2 years.

    “Notably, a 2-year randomized control trial (RCT) examining whey protein ingestion and bone health in postmenopausal women determined that high whey consumption resulted in higher serum IGF-1 levels, 7.3% at 1 year and 8% at 2 years.18”

    From Diet and acne: A systematic review (2022) · cites this paper as [18]

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Authors
Runchey, S. S., Pollak, M. N., Valsta, L. M., Coronado, G. D., Schwarz, Y., Breymeyer, K. L., Wang, C., Wang, C.-Y., Lampe, J. W., & Neuhouser, M. L.
Affiliations
  • University of Washington (US)
  • Jewish General Hospital (CA)
  • European Food Safety Authority (IT)
  • Kaiser Permanente (US)
  • Fred Hutch Cancer Center (US)
Corresponding author
Neuhouser, M L
ORCID
Venue
European Journal of Clinical Nutrition
Publisher
Springer Science and Business Media LLC
Published
2012-08-15
Volume
66
Issue
10
Pages
1146-1152
ISSN
  • 0954-3007 (ISSN-L)
  • 1476-5640
DOI
10.1038/ejcn.2012.107
PMC
PMC3463643
OpenAlex
W1990888294
Cited by
56
References
6
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 1
FWCI
3.40
Type
journal article
Language
en
Open access
Licence
Locations
  • European Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (T32HL007028)
  • National Cancer Institute (R03CA132158, U54CA116847, P30CA015704)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
Keywords
glycemic load, low glycemic load diet, insulin-like growth factor I, IGF binding protein-3, IGF-1/IGFBP-3 ratio, postprandial blood glucose, postprandial insulin, fasting blood glucose, insulin resistance, obesity, overweight, chronic disease risk, dietary intervention
MeSH terms
Adult, Algorithms, Blood Glucose, Dietary Carbohydrates, Female, Humans, Hyperglycemia, Hyperinsulinism, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Male, Obesity, Biomarkers, Body Mass Index, Cross-Over Studies, Insulin-Like Growth Factor Binding Protein 3, Glycemic Index, Overweight, Young Adult

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