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Cited by 663Nutritional Studies and DietFatty Acid Research and HealthCardiovascular Health and Risk Factors

The DOI matches its Crossref record; 37 of the 39 references it cites were found in a registry or an index.

Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial

Singh, Ram B, Dubnov, Gal, Niaz, Mohammad A, Ghosh, Saraswati, Singh, Reema, Rastogi, Shanti S, Manor, Orly, Pella, Daniel, Berry, Elliot M·2002·The Lancet
DOI 10.1016/s0140-6736(02)11472-3
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Abstract

Background The rapid emergence of coronary artery disease (CAD) in south Asian people is not explained by conventional risk factors. In view of cardioprotective effects of a Mediterranean style diet rich in alpha-linolenic acid, we assessed the benefits of this diet for patients at high risk of CAD.Methods We did a randomised, single-blind trial in 1000 patients with angina pectoris, myocardial infarction, or surrogate risk factors for CAD. 499 patients were allocated to a diet rich in whole grains, fruits, vegetables, walnuts, and almonds. 501 controls consumed a local diet similar to the step I National Cholesterol Education Program (NCEP) prudent diet.Findings The intervention group consumed more fruits, vegetables, legumes, walnuts, and almonds than did controls (573 g [SD 127] vs 231 g [19] per day p<0.001). The intervention group had an increased intake of whole grains and mustard or soy bean oil. The mean intake of alpha-linolenic acid was two-fold greater in the intervention group (1.8 g [SD 0.4] vs 0.8 g [0.2] per day, p<0.001). Total cardiac end points were significantly fewer in the intervention group than the controls (39 vs 76 events, p<0.001). Sudden cardiac deaths were also reduced (6 vs 16, p=0.015), as were non-fatal myocardial infarctions (21 vs 43, p<0.001). We noted a significant reduction in serum cholesterol concentration and other risk factors in both groups, but especially in the intervention diet group. In the treatment group, patients with pre-existing CAD had significantly greater benefits compared with such patients in the control group.Interpretation An Indo-Mediterranean diet that is rich in alpha-linolenic acid might be more effective in primary and secondary prevention of CAD than the conventional step I NCEP prudent diet.

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Crossref · 10.1016/s0140-6736(02)11472-3

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Citations

Cites

Research works printed but not linked: 3

  1. 1996, Indian Consensus for prevention of hypertension and coronary artery disease. A scientific statement of the Indian society of hypertension and international college of nutrition, J Nutr Environ Med, 6, 309
  2. Singh, 1997, Validation of physical activity and socioeconomics status questionnaire in relation to food intakes for the Five City Study and proposed classification for Indians, J Assoc Physicians India, 45, 603
  3. Van Handel, 1957, Micromethod in the direct estimation of triglycerides, J Lab Clin Med, 60, 152

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Metadata

Authors
Singh, R. B., Dubnov, G., Niaz, M. A., Ghosh, S., Singh, R., Rastogi, S. S., Manor, O., Pella, D., & Berry, E. M.
Affiliations
  • Teerthanker Mahaveer Medical College & Research Centre (IN)
  • Hebrew University of Jerusalem (IL)
Corresponding author
Berry, Elliot M
ORCID
Venue
The Lancet
Publisher
Elsevier BV
Published
2002-11
Volume
360
Issue
9344
Pages
1455-1461
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(02)11472-3
OpenAlex
W2093983853
Cited by
663
References
39
Citations by year
2026: 8 · 2025: 12 · 2024: 11 · 2023: 14 · 2022: 12 · 2021: 25 · 2020: 11 · 2019: 19 · 2018: 25 · 2017: 18 · 2016: 19 · 2015: 25 · 2014: 25 · 2013: 21 · 2012: 37
FWCI
57.17
Type
journal article
Language
en
Update notices
expression_of_concern (2005-07-30)
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords
coronary artery disease, alpha-linolenic acid, dietary intervention, angina pectoris, myocardial infarction, sudden cardiac death, whole grains, nuts, fruits and vegetables, serum cholesterol, secondary prevention, South Asian populations
MeSH terms
Angina Pectoris, Coronary Artery Disease, Female, Humans, Male, Middle Aged, Myocardial Infarction, Risk Factors, Proportional Hazards Models, Survival Analysis, Single-Blind Method, Disease Progression, Diet, Mediterranean

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