Corn Oil in Treatment of Ischaemic Heart Disease
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(3) Absence of heart failure, and also of any non-cardiac disease likely to threaten life within two years. (4) Absence of personal or geographical factors likely to interfere with clinic attendance or the taking of oil. When a new patient was accepted for the trial a sealed envelope was opened containing the allocation instructions. In the case of patients allocated to an oil group the instructions referred only to a code number. Thus the physicians in charge knew which patients were receiving oil, but they did not know until the end of the trial the kind of oil that they were receiving. All patients received conventional treatments, at the discre tion of the physicians. At the time when the trial started long-term anticoagulant therapy was seldom used. Later it became more popular, especially for patients suffering reinfarction. To avoid confusion by possible interactions between treatments a few patients already receiving this treat ment were excluded from entry to the trial ; and in addition the occurrence of infarction after entry was taken as an end point, the patient being then withdrawn from the trial. Patients in both oil groups were instructed to avoid fried
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Seven trials exhibited some concerns on RoB2, and 2 trials exhibited a high risk of bias.
“Seven trials exhibited some concerns (15), (19), (20), (21), (22), (24), (25), and 2 trials exhibited a high risk of bias (18), (23).”
From Saturated Fat Restriction for Cardiovascular Disease Prevention: A Systematic Review and Meta-analysis of Randomized Controlled Trials (2025) · cites this paper as [18]
The study by Rose et al. and the Sydney Diet Heart Study were among the top 2 negative studies that would have provided valuable contributions to the analysis by Mozaffarian et al.
“For example, the study by Rose et al. (18) and the Sydney Diet Heart Study (24) were among the top 2 negative studies (Figure 2) that would have provided valuable contributions to the analysis by Mozaffarian et al. (26)”
From Saturated Fat Restriction for Cardiovascular Disease Prevention: A Systematic Review and Meta-analysis of Randomized Controlled Trials (2025) · cites this paper as [18]
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- Authors
- Rose, G. A., Thomson, W. B., & Williams, R. T.
- Affiliations
- Western General Hospital (GB)
- St Mary's Hospital (GB)
- ORCID
- Rose, G. A.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1965-06-12
- Volume
- 1
- Issue
- 5449
- Pages
- 1531-1533
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC2166702
- OpenAlex
- W2047709447
- Cited by
- 197
- References
- 0
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 10 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 5
- FWCI
- 11.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- corn oil, ischemic heart disease, dietary fat, cholesterol lowering, myocardial infarction prevention, anticoagulation, reinfarction
- MeSH terms
- Angina Pectoris, Cholesterol, Corn Oil, Coronary Artery Disease, Diet, Diet Therapy, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, Humans, Myocardial Infarction, Oils, Statistics as Topic, Myocardial Ischemia
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