Cited by 816Influenza Virus Research StudiesRespiratory viral infections researchViral Infections and Outbreaks Research

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Re-emergence of fatal human influenza A subtype H5N1 disease

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Peiris, JSM, Yu, WC, Leung, CW, Cheung, CY, Ng, WF, Nicholls, JM, Ng, TK, Chan, KH, Lai, ST, Lim, WL, Yuen, KY, Guan, Y·2004·The Lancet

DOI 10.1016/s0140-6736(04)15595-5PMC PMC7112424

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Abstract

Human disease associated with influenza A subtype H5N1 re-emerged in January, 2003, for the first time since an outbreak in Hong Kong in 1997. Patients with H5N1 disease had unusually high serum concentrations of chemokines (eg, interferon induced protein-10 [IP-10] and monokine induced by interferon gamma [MIG]). Taken together with a previous report that H5N1 influenza viruses induce large amounts of proinflammatory cytokines from macrophage cultures in vitro, our findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease. Development of vaccines against influenza A (H5N1) virus should be made a priority.

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Authors: Peiris, J., Yu, W., Leung, C., Cheung, C., Ng, W., Nicholls, J., Ng, T., Chan, K., Lai, S., Lim, W., Yuen, K., & Guan, Y.
Affiliations: Queen Mary Hospital (CN)
Princess Margaret Hospital (HK)
Department of Health (CN)
ORCID: Guan, Y
Venue: The Lancet
Publisher: Elsevier BV
Published: 2004-02
Volume: 363
Issue: 9409
Pages: 617-619
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(04)15595-5
PMC: PMC7112424
OpenAlex: W2052374402
Cited by: 812
References: 5
Citations by year: 2026: 5 · 2025: 10 · 2024: 13 · 2023: 20 · 2022: 22 · 2021: 20 · 2020: 20 · 2019: 22 · 2018: 26 · 2017: 20 · 2016: 10 · 2015: 32 · 2014: 42 · 2013: 47 · 2012: 40
FWCI: 55.80
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders: Wellcome Trust
National Institutes of Health (n01ai095357-001)
National Institute of Allergy and Infectious Diseases (N01 AI095357, AI 95357)
Topics: Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
Keywords: H5N1 avian influenza, avian influenza, fatal influenza, chemokines, monokine induced by interferon-gamma, inflammatory cytokines, pathogenesis, influenza vaccine development, 2003 outbreak
MeSH terms: Animals, China, Disease Outbreaks, Influenza in Birds, Hong Kong, Humans, Influenza, Human, Influenza A virus, Poultry, Poultry Diseases, Zoonoses, Influenza A Virus, H5N1 Subtype

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Re-emergence of fatal human influenza A subtype H5N1 disease

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