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Re-emergence of fatal human influenza A subtype H5N1 disease
Open accessAbstract
Human disease associated with influenza A subtype H5N1 re-emerged in January, 2003, for the first time since an outbreak in Hong Kong in 1997. Patients with H5N1 disease had unusually high serum concentrations of chemokines (eg, interferon induced protein-10 [IP-10] and monokine induced by interferon gamma [MIG]). Taken together with a previous report that H5N1 influenza viruses induce large amounts of proinflammatory cytokines from macrophage cultures in vitro, our findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease. Development of vaccines against influenza A (H5N1) virus should be made a priority.
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“The rapid and intense nature of the host inflammatory response is the suspected cause of severe lung damage (116).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [116]
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“The paradigm of “hit hard and hit early” popularized for the treatment of AIDS also appears to apply to the way H5N1 avian influenza virus causes tissue damage in human infections.”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [116]
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Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus
Claas, E. C. J., Osterhaus, A. D. M. E., van Beek, R., de Jong, J. C., Rimmelzwaan, G. F., Senne, D. A., Krauss, S. L., Shortridge, K. F., & Webster, R. G. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11212-0 · Cited by 1,420
Yuen, K., Chan, P., Peiris, M. J. S., Tsang, D., Que, T., Shortridge, K. F., Cheung, P., To, W., Ho, E., Sung, R. Y. T., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)01182-9 · Cited by 1,054
Self-citationCheung, C., Poon, L., Lau, A., Luk, W., Lau, Y., Shortridge, K., Gordon, S., Guan, Y., & Peiris, J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11772-7 · Cited by 889
Self-citationKoopmans, M., Wilbrink, B., Conyn, M., Natrop, G., van der Nat, H., Vennema, H., Meijer, A., van Steenbergen, J., Fouchier, R. A. M., Osterhaus, A. D. M. E., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15589-x · Cited by 829
Targets of a protease inhibitor, KNI-272, in HIV-1-infected cells
Goto, T., Nakano, T., Kohno, T., Morimatsu, S., Morita, C., Wu, H. Y., Kiso, Y., Nakai, M., & Sano, K. (2001) · Journal of Medical Virology · doi:10.1002/1096-9071(200103)63:3 · Cited by 5
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Zhang, L. (2011) · UKnowledge (University of Kentucky) · Cited by 2
Chen, S., Wang, X., Su, X., Miao, X., Qin, T., Peng, D., & Liu, X. (2020) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2020.104672 · Cited by 2
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Vidal, J. (2005) · Vacunas · doi:10.1016/s1576-9887(05)73018-1 · Cited by 1
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Wood, J., & Robertson, J. S. (2004) · Weekly releases (1997–2007) · doi:10.2807/esw.08.25.02489-en · Cited by 1
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Niman, H. L., Niman, H. L., Saad, M. D., Boynton, B. R., Tjaden, J., Earhart, K. C., Mansour, M. M., El-Sayed, N., Nayei, A., Abdelghani, A., et al. (2007) · Space Resolver 16 · doi:10.1038/npre.2007.553.1
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Iteman, I., Michault, A., Murri, S., Frangeul, L., Vaney, M. C., Aj, Z., Pattison, Sons Ltd, Peiris, M. J. S., Yu, W., et al. (2006)
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Pessanha, W. (2006) · Americanae (AECID Library)
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pandemican influenza-like illness during an influenza Pandemic flu: clinical management of patients
Lim, W. S. (2007)
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Yongping, J., Zhang, H., Bu, Z., Li, C., You-shu, Z., Wang, X., & Kangzhen, Y. (2006) · Zhongguo nongye Kexue
Walker, P. G. T. (2011) · Spiral (Imperial College London) · doi:10.25560/6966
Al-Abbasi, A. M., Sultan, S. S. N., & Witwit, M. L. (2006) · Medical Journal of Babylon
Darwish, I. (2012) · TSpace (University of Toronto)
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Hampson, A. W. (2006) · Microbiology Australia · doi:10.1071/ma06159
Morrison, L. J., Alter, J. S., Ginsburg, M., Marx, J. H., & Blee, K. M. (2003)
Agusta, I., JACINTA, S., & Yap, W. B. (2020) · Jurnal Sains Kesihatan Malaysia · doi:10.17576/jskm-2020-1802-08
Eman (2020) · International Journal for Research in Applied Science and Engineering Technology · doi:10.22214/ijraset.2020.30332
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間辺, 利. (2018) · Institutional Repositories DataBase (IRDB) · doi:10.24557/kokyurinsho.2.e00034
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Williams, J. V. (2007) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-8099-1_13
Yang, G., Su, D.-N., & Qiu, C. (2021) · Springer eBooks · doi:10.1007/978-981-16-1429-3_16
(2014) · ASM Press eBooks · doi:10.1128/9781555817510.refs
Bouvresse, S., Bricaire, F., & Bossi, P. (2007) · EMC - Traité de médecine AKOS · doi:10.1016/s1634-6939(07)45399-6
Bouvresse, S., Bricaire, F., & Bossi, P. (2007) · EMC - Tratado de Medicina · doi:10.1016/s1636-5410(07)70643-8
Bouvresse, S., Bricaire, F., & Bossi, P. (2007) · EMC - AKOS - Trattato di Medicina · doi:10.1016/s1634-7358(07)70392-3
Update on Avian Influenza for Critical Care Physicians
Sandrock, C. (2007) · Yearbook of intensive care and emergency medicine · doi:10.1007/978-3-540-49433-1_90
Use molecular barcodes to study emerging infectious diseasesPreprint
Chen, H. (2022) · doi:10.22541/au.165285401.15076943/v1
Controlling COVID-19 and Preparing forFuture Pandemics
Barry, D. M., & Kanematsu, H. (2022) · Springer eBooks · doi:10.1007/978-981-19-1356-3_11
(2020) · Flammarion eBooks · doi:10.3917/flam.quamm.2020.01.0519
Ativação do inflamassoma: a importância na leishmaniose, na influenza e na COVID-19
de Sá, K. S. G. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2022.tde-03022023-110423
Chen, F., Li, L., Liu, Y., Fei, W., Kong, L., Guo, Y., Mu, D., Zhang, X., Yang, X., Wang, H., et al. (2023) · Springer eBooks · doi:10.1007/978-981-99-4614-3_6
Liu, X., Luo, W.-T., Li, Y., Li, C., Hong, Z., Chen, H., Xiao, F., & Xia, J. (2020) · Figshare · doi:10.6084/m9.figshare.12399236
Novel insights in the serodiagnosis and pathogenesis of swine influenza
Barbé, F. (2009) · Ghent University Academic Bibliography (Ghent University)
Critical role of interleukin-17 receptor signaling in the immunopathology of influenza infection
Crowe, C. R. (2009) · D-Scholarship@Pitt (University of Pittsburgh)
Luo, R., Lv, C., Wang, T., Deng, X., Sima, M., Guo, J., Qi, J., Sun, W., Shen, B., Li, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24494185
Zhang, S., Sun, F., Zhu, J., Qi, J., Wang, W., Liu, Z., Li, W., Liu, C., 刘学焕, Wang, N., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24558055
Metadata
- Authors
- Peiris, J., Yu, W., Leung, C., Cheung, C., Ng, W., Nicholls, J., Ng, T., Chan, K., Lai, S., Lim, W., Yuen, K., & Guan, Y.
- Affiliations
- Queen Mary Hospital (CN)
- Princess Margaret Hospital (HK)
- Department of Health (CN)
- ORCID
- Guan, Y
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 363
- Issue
- 9409
- Pages
- 617-619
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC7112424
- OpenAlex
- W2052374402
- Cited by
- 812
- References
- 5
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 13 · 2023: 20 · 2022: 22 · 2021: 20 · 2020: 20 · 2019: 22 · 2018: 26 · 2017: 20 · 2016: 10 · 2015: 32 · 2014: 42 · 2013: 47 · 2012: 40
- FWCI
- 55.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- Wellcome Trust
- National Institutes of Health (n01ai095357-001)
- National Institute of Allergy and Infectious Diseases (N01 AI095357, AI 95357)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Keywords
- H5N1 avian influenza, avian influenza, fatal influenza, chemokines, monokine induced by interferon-gamma, inflammatory cytokines, pathogenesis, influenza vaccine development, 2003 outbreak
- MeSH terms
- Animals, China, Disease Outbreaks, Influenza in Birds, Hong Kong, Humans, Influenza, Human, Influenza A virus, Poultry, Poultry Diseases, Zoonoses, Influenza A Virus, H5N1 Subtype
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