Fetuin protects the fetus from TNF
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AHSG/Fetuin-A is a required co-factor for the anti-inflammatory activity of spermine.
“The cellular protein alpha-2-HS-glycoprotein (AHSG, also known as Fetuin-A) has been reported to be a required co-factor for the anti-inflammatory activity of spermine”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as H. Wang et al., 1997
Cites
Zhang, M., Caragine, T., Wang, H., Cohen, P. S., Botchkina, G., Soda, K., Bianchi, M., Ulrich, P., Cerami, A., Sherry, B., et al. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.10.1759 · Cited by 317 · see citing works
Self-citationShaarawy, M., & Nagui, A. R. (1997) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/j.1600-0412.1997.tb07846.x · Cited by 62 · see citing works
Mallmann, P. K., Mallmann, R., & Krebs, D. (1991) · Archives of Gynecology and Obstetrics · doi:10.1007/bf02390365 · Cited by 45 · see citing works
Eason, J. D., Wee, S., Kawai, T., et al. (1995) · Transplantation · doi:10.1097/00007890-199501000-00025 · Cited by 30 · see citing works
Eason, J. D., Wee, S., Kawai, T., et al. (1995) · Transplantation · doi:10.1097/00007890-199501270-00025 · Cited by 30 · see citing works
Shaarawy, M., & Nagui, A. R. (1997) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016349709047796 · Cited by 28 · see citing works
Anderson, J. M., & Ferguson-Smith, M. A. (1971) · BMJ · doi:10.1136/bmj.2.5754.166-c · Cited by 23 · see citing works
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Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876 · see citing works
“Indeed, spermine administration exhibits protective anti-inflammatory effects in mouse models of both localized and systemic inflammation (ter Steege et al., 1999; Zhang et al., 1997; Zhu et al., 2009).”
BackgroundIs the anti-inflammatory effect of regular exercise responsible for reduced cardiovascular disease?
Wilund, K. R. (2007) · Clinical Science · doi:10.1042/cs20060368 · Cited by 138 · see citing works
Spermine inhibition of monocyte activation and inflammation
Zhang, M., Borovikova, L. V., Wang, H., Metz, C., & Tracey, K. J. (1999) · Molecular Medicine · doi:10.1007/bf03402072 · Cited by 92 · see citing works
- Authors
- Wang, H., Zhang, M., Soda, K., Sama, A., & Tracey, K. J.
- Affiliations
- North Shore University Hospital (US)
- Corresponding author
- Wang, Haichao
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1997-09
- Volume
- 350
- Issue
- 9081
- Pages
- 861-862
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2053420699
- Cited by
- 74
- References
- 7
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 4
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Keywords
- fetuin-A, TNF-α, spermine, fetal immune tolerance, pregnancy, allograft rejection, miscarriage, cytokine inhibition, amniotic membrane, mononuclear cells
- MeSH terms
- alpha-Fetoproteins, Animals, Female, Humans, Macrophages, Pregnancy, Spermine, Tumor Necrosis Factor-alpha, Mice, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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