The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Genetic association studies
Abstract
We review the rationale behind and discuss methods of design and analysis of genetic association studies. There are similarities between genetic association studies and classic epidemiological studies of environmental risk factors but there are also issues that are specific to studies of genetic risk factors such as the use of particular family-based designs, the need to account for different underlying genetic mechanisms, and the effect of population history. Association differs from linkage (covered elsewhere in this series) in that the alleles of interest will be the same across the whole population. As with other types of genetic epidemiological study, issues of design, statistical analysis, and interpretation are very important.
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Cites
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Genomic Control for Association Studies
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Self-citationA General Test of Association for Quantitative Traits in Nuclear Families
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Cited by
Genome-wide association studies for complex traits: consensus, uncertainty and challenges
McCarthy, M. I., Abecasis, G. R., Cardon, L. R., Goldstein, D. B., Little, J., Ioannidis, J. P. A., & Hirschhorn, J. N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2344 · Cited by 2,891
Little, J., Higgins, J. P. T., Ioannidis, J. P. A., Moher, D., Gagnon, F., von Elm, E., Khoury, M. J., Cohen, B., Davey-Smith, G., Grimshaw, J., et al. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000022 · Cited by 811
What makes a good genetic association study?
Hattersley, A. T., & McCarthy, M. I. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67531-9 · Cited by 470
Epidemiology of preterm birth and its clinical subtypes
Ananth, C. V., Ananth, C. V., & Vintzileos, A. M. (2006) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050600965882 · Cited by 461
A Genomic Pathway Approach to a Complex Disease: Axon Guidance and Parkinson Disease
Lesnick, T. G., Papapetropoulos, S., Mash, D. C., Ffrench-Mullen, J., Shehadeh, L., de Andrade, M., Henley, J. R., Rocca, W. A., Ahlskog, J. E., & Maraganore, D. M. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030098 · Cited by 411
Metadata
- Authors
- Cordell, H. J., & Clayton, D. G.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 366
- Issue
- 9491
- Pages
- 1121-1131
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2073527744
- Cited by
- 582
- References
- 17
- FWCI
- 31.59
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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