Cited by 850Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesDiet and metabolism studies

The DOI matches its Crossref record; 317 of the 321 references it cites were found in a registry or an index.

Epilepsy in children

Guerrini, Renzo·2006·The Lancet

Open this paper in CoChat — free account

Abstract

10.5 million children worldwide are estimated to have active epilepsy. Over the past 15 years, syndrome-oriented clinical and EEG diagnosis, and better aetiological diagnosis, especially supported by neuroimaging, has helped to clarify the diversity of epilepsy in children, and has improved management. Perinatal and postinfective encephalopathy, cortical dysplasia, and hippocampal sclerosis account for the most severe symptomatic epilepsies. Ion channel defects can underlie both benign age-related disorders and severe epileptic encephalopathies with a progressive disturbance in cerebral function. However, the reasons for age-related expression in children are not understood. Neither are the mechanisms whereby an epileptic encephalopathy originates. Several new drugs have been recently introduced but have provided limited therapeutic benefits. However, treatment and quality of life have improved because the syndrome-specific efficacy profile of drugs is better known, and there is heightened awareness that compounds with severe cognitive side-effects and heavy polytherapies should be avoided. Epilepsy surgery is an important option for a few well-selected individuals, but should be considered with great caution when there is no apparent underlying brain lesion.

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(06)68182-8

Cites

317 of 317 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

2 retracted

Retraction Note: Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies
Haug, K., Warnstedt, M., Alekov, A. K., Sander, T., Ramı́rez, A., Poser, B., Maljevic, S., Hebeisen, S., Kubisch, C., Rebstock, J., et al. (2009) · Nature Genetics · doi:10.1038/ng0909-1043 · Cited by 306
Retracted
Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies
Haug, K., Warnstedt, M., Alekov, A. K., Sander, T., Ramı́rez, A., Poser, B., Maljevic, S., Hebeisen, S., Kubisch, C., Rebstock, J., et al. (2003) · Nature Genetics · doi:10.1038/ng1121 · Cited by 293
Retracted
Proposal for Revised Classification of Epilepsies and Epileptic Syndromes: Commission on Classification and Terminology of the International League Against Epilepsy
(1989) · Epilepsia · doi:10.1111/j.1528-1157.1989.tb05316.x · Cited by 5,347
Early Identification of Refractory Epilepsy
Kwan, P., & Brodie, M. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002033420503 · Cited by 5,204
Epileptic Seizures and Epilepsy: Definitions Proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)
Fisher, R. S., Boas, W. V. E., Blume, W. T., Elger, C. E., Genton, P., Lee, P., & Engel, J. (2005) · Epilepsia · doi:10.1111/j.0013-9580.2005.66104.x · Cited by 3,678
Proposal for Revised Clinical and Electroencephalographic Classification of Epileptic Seizures
(1981) · Epilepsia · doi:10.1111/j.1528-1157.1981.tb06159.x · Cited by 3,433
Surgical Treatment of the Epilepsies
Kotagal, P. (1994) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199407000-00009 · Cited by 2,759
Epilepsy: A Comprehensive Textbook
(2008) · JAMA · doi:10.1001/jama.300.4.443-a · Cited by 2,357
A Proposed Diagnostic Scheme for People with Epileptic Seizures and with Epilepsy: Report of the ILAE Task Force on Classification and Terminology
Engel, J. (2001) · Epilepsia · doi:10.1046/j.1528-1157.2001.10401.x · Cited by 2,248
Incidence of Epilepsy and Unprovoked Seizures in Rochester, Minnesota: 1935–1984
Hauser, W. A., Annegers, J. F., & Kurland, L. T. (1993) · Epilepsia · doi:10.1111/j.1528-1157.1993.tb02586.x · Cited by 2,084

Show all 321 references

Research works printed but not linked: 1

Erba, 1990, Sturge-Weber syndrome: Natural history and indications for surgery, J Epilepsy, 3, 287

Sorted by citations

Items 101–200 of 850

Gestational Age, Birth Weight, Intrauterine Growth, and the Risk of Epilepsy
Sun, Y., Vestergaard, M., Pedersen, C. B., Christensen, J., Basso, O., & Olsen, J. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm316 · Cited by 81
The model of pentylenetetrazol-induced status epilepticus in the immature rat: short- and long-term effects
Nehlig, A., & de Vasconcelos, A. P. (1996) · Epilepsy Research · doi:10.1016/s0920-1211(96)00045-9 · Cited by 80
Complex dynamics and bifurcations in neurology
MILTON, J. G., Longtin, A., Beuter, A. C., Mackey, M. C., & Glass, L. (1989) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(89)80135-3 · Cited by 80
Comparison of AR and Welch Methods in Epileptic Seizure Detection
Alkan, A., & Kıymık, M. K. (2006) · Journal of Medical Systems · doi:10.1007/s10916-005-9001-0 · Cited by 79
Electroclinical signs of benign neonatal familial convulsions
Hirsch, É., Vélez-van-Meerbeke, A., Sellal, F., Maton, B., Grinspan, A., Malafosse, A., & Marescaux, C. (1993) · Annals of Neurology · doi:10.1002/ana.410340613 · Cited by 78
Duration of rhythmic EEG patterns in neonates: new evidence for clinical and prognostic significance of brief rhythmic discharges
Oliveira, A. J., Nunes, M. L., Haertel, L. M., dos Reis, F. M., & da Costa, J. C. (2000) · Clinical Neurophysiology · doi:10.1016/s1388-2457(00)00380-1 · Cited by 77
Epidemiology of Epilepsy in Guaymi Indians from Bocas del Toro Province, Republic of Panama
Gracia, F., Lao, S. L. D., Castillo, L. C., Larreategui, M., Archbold, C., Brenes, M. M., & Reeves, W. C. (1990) · Epilepsia · doi:10.1111/j.1528-1157.1990.tb05512.x · Cited by 77
Acquired Aphasia, Dementia, and Behavior Disorder with Epilepsy and Continuous Spike and Waves During Sleep in a Child
Roulet, E., Deonna, T. W., Gaillard, F., Peter-Favre, C., & Despland, P. (1991) · Epilepsia · doi:10.1111/j.1528-1157.1991.tb04683.x · Cited by 77
Cognitive impairment in childhood onset epilepsy: up-to-date information about its causes
Kim, E., & Ko, T. (2016) · Korean Journal of Pediatrics · doi:10.3345/kjp.2016.59.4.155 · Cited by 76
Apgar Scores and Long-Term Risk of Epilepsy
Sun, Y., Vestergaard, M., Pedersen, C. B., Christensen, J., & Olsen, J. (2006) · Epidemiology · doi:10.1097/01.ede.0000208478.47401.b6 · Cited by 75
Physiological Rationale for Suppression of Fever
Mackowiak, P. A. (2000) · Clinical Infectious Diseases · doi:10.1086/317511 · Cited by 74
Neonatal seizures: a clinician's overview
LOMBROSO, C. T. (1996) · Brain and Development · doi:10.1016/s0387-7604(96)90001-7 · Cited by 74
Preeclampsia and Neurodevelopmental Outcomes: Potential Pathogenic Roles for Inflammation and Oxidative Stress?
Barron, A., McCarthy, C., & O’Keeffe, G. W. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02290-4 · Cited by 73
Epidemiology of childhood epilepsy in a cohort of 309 Chinese children
Kwong, K. L., Chak, W. K., Wong, S. N., & So, K. T. (2001) · Pediatric Neurology · doi:10.1016/s0887-8994(01)00247-8 · Cited by 73
Unusual Variants of Infantile Spasms
Donat, J. F. G., & Wright, F. S. (1991) · Journal of Child Neurology · doi:10.1177/088307389100600405 · Cited by 72
The medical management of the epilepsies in children: conceptual and practical considerations
Raspall‐Chaure, M., Neville, B. G. R., & Scott, R. C. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70324-1 · Cited by 75
Acquired Epileptiform Opercular Syndrome: A Second Case Report, Review of the Literature, and Comparison to the Landau‐Kleffner Syndrome
Shafrir, Y., & Prensky, A. L. (1995) · Epilepsia · doi:10.1111/j.1528-1157.1995.tb00965.x · Cited by 71
Regulation of ABC Transporters at the Blood-Brain Barrier: New Targets for CNS Therapy
Hartz, A. M. S., & Bauer, B. (2010) · Molecular Interventions · doi:10.1124/mi.10.5.6 · Cited by 70
Rotavirus Encephalitis Mimicking Afebrile Benign Convulsions in Infants
Hongou, K., Konishi, T., Yagi, S., Araki, K., & Miyawaki, T. (1998) · Pediatric Neurology · doi:10.1016/s0887-8994(97)00206-3 · Cited by 70
Genetic susceptibility to simple febrile seizures: Interleukin-1β promoter polymorphisms are associated with sporadic cases
Kira, R., Torisu, H., Takemoto, M., Nomura, A., Sakai, Y., Sanefuji, M., Sakamoto, K., Matsumoto, S., Gondo, K., & Hara, T. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.04.097 · Cited by 69
Anesthetic management of the patient with epilepsy or prior seizures
Kofke, W. A. (2010) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e328339250b · Cited by 69
Prenatal Etiologies of West Syndrome
Ohtahara, S., Ohtsuka, Y., Yamatogi, Y., Oka, E., Yoshinaga, H., & Sato, M. (1993) · Epilepsia · doi:10.1111/j.1528-1157.1993.tb00451.x · Cited by 69
Rectal diazepam gel for treatment of acute repetitive seizures
Kriel, R. L., Cloyd, J. C., Pellock, J. M., Mitchell, W. G., Cereghino, J. J., & Rosman, N. P. (1999) · Pediatric Neurology · doi:10.1016/s0887-8994(98)00156-8 · Cited by 68
Epilepsy and epileptiform EEG: Association with autism and language disorders
Ballaban‐Gil, K. R., & Tuchman, R. F. (2000) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/1098-2779(2000)6:4 · Cited by 171
Postnatal development of synchronized network oscillations in the ferret dorsal lateral geniculate and perigeniculate nuclei
McCormick, D. A., Trent, F., & Ramoa, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05739.1995 · Cited by 68
Focal abnormalities detected by 18FDG PET in epileptic encephalopathies.
Ferrie, C. D., Maisey, M. N., Cox, T. C. S., Polkey, C. E., Barrington, S. F., PANAYIOTOPOULOS, C. P., & Robinson, R. O. (1996) · Archives of Disease in Childhood · doi:10.1136/adc.75.2.102 · Cited by 66
Neurophysiology of positive and negative myoclonus
Tassinari, C. A., Rubboli, G., & Shibasaki, H. (1998) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/s0013-4694(98)00058-3 · Cited by 66
Synaptic transmission in human neocortex removed for treatment of intractable epilepsy in children
Wuarin, J., Kim, Y. I., Cepeda, C., Tasker, J. G., Walsh, J. P., Peacock, W. J., Buchwald, N. A., & Dudek, F. E. (1990) · Annals of Neurology · doi:10.1002/ana.410280406 · Cited by 66
Prevalence, incidence, and trends of epilepsy among children and adolescents in Africa: a systematic review and meta-analysis
Biset, G., Abebaw, N., Gebeyehu, N. A., Estifanos, N., Wondifraw, E. B., & Tegegne, K. D. (2024) · BMC Public Health · doi:10.1186/s12889-024-18236-z · Cited by 78
Neurotoxins from invertebrates as anticonvulsants: From basic research to therapeutic application
Mortari, M. R., Cunha, A. O. S., Ferreira, L. B., & dos Santos, W. F. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.01.009 · Cited by 64
Effects of epilepsy and valproic acid on oxidant status in children with idiopathic epilepsy
Yiş, U., Seçkin, E., Kurul, S. H., Kuralay, F., & Dırık, E. (2009) · Epilepsy Research · doi:10.1016/j.eplepsyres.2009.02.003 · Cited by 64
The Contributions of Epidemiology to the Understanding of Childhood Seizures and Epilepsy
Berg, A. T., & Shinnar, S. (1994) · Journal of Child Neurology · doi:10.1177/0883073894009002041 · Cited by 64
Selective death of hippocampal CA3 pyramidal cells with mossy fiber afferents after CRH-induced status epilepticus in infant rats
Ribak, C. E., & Baram, T. Z. (1996) · Developmental Brain Research · doi:10.1016/0165-3806(95)00183-2 · Cited by 63
Visual Contrast Gain Control in Migraine: Measures of Visual Cortical Excitability and Inhibition
McColl, S. L., & Wilkinson, F. (2000) · Cephalalgia · doi:10.1046/j.1468-2982.2000.00033.x · Cited by 61
Neonatal Status Convulsivus, Spongiform Encephalopathy, and Low Activity of Na+/K+ ‐ATPase in the Brain
Renkawek, K., Renier, W. O., Pont, J.-J. H. H. M. D., Vogels, O. J. M., & Gabreëls, F. J. M. (1992) · Epilepsia · doi:10.1111/j.1528-1157.1992.tb02283.x · Cited by 61
Do seizures damage the brain? The epidemiological evidence
Verity, C. M. (1998) · Archives of Disease in Childhood · doi:10.1136/adc.78.1.78 · Cited by 60
Myoclonic–astatic epilepsy of early childhood – clinical and EEG analysis of myoclonic–astatic seizures, and discussions on the nosology of the syndrome
Oguni, H., Fukuyama, Y., Tanaka, T., Hayashi, K., Funatsuka, M., Sakauchi, M., Shirakawa, S., & Ōsawa, M. (2001) · Brain and Development · doi:10.1016/s0387-7604(01)00281-9 · Cited by 59
Risk Factors for Epilepsy: Case‐Control Study in Nigerians
Ogunniyi, A. O., Osuntokun, B. O., Bademosi, O., Adeuja, A. O. G., & Schoenberg, B. S. (1987) · Epilepsia · doi:10.1111/j.1528-1157.1987.tb04219.x · Cited by 58
Are rats with genetic absence epilepsy behaviorally impaired?
Vergnes, M., Marescaux, C., Boehrer, A., & Depaulis, A. (1991) · Epilepsy Research · doi:10.1016/0920-1211(91)90019-c · Cited by 58
The effects of ketogenic diet on the Th17/Treg cells imbalance in patients with intractable childhood epilepsy
Ni, F.-F., Li, C.-R., Liao, J., Wang, G., Lin, S., Xia, Y., & Wen, J. (2016) · Seizure · doi:10.1016/j.seizure.2016.03.006 · Cited by 59
Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts
Naesens, L. M. J., Bonnafous, P., Agut, H., & Clercq, E. D. (2006) · Journal of Clinical Virology · doi:10.1016/s1386-6532(06)70015-4 · Cited by 57
Acute Symptomatic Seizure Disorders in Young Children—A Population Study in Southern Taiwan
Huang, C., Chang, Y., & Wang, S. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb01445.x · Cited by 57
Congenital hemiparesis, unilateral polymicrogyria and epilepsy with or without status epilepticus during sleep: a study of 66 patients with long‐term follow‐up
Caraballo, R. H., Cersósimo, R. O., Fortini, P. S., Ornella, L., Buompadre, M. C., Vilte, C., Princich, J. P., & Fejerman, N. (2013) · Epileptic Disorders · doi:10.1684/epd.2013.0612 · Cited by 56
Safety and Tolerability of Antiepileptic Drug Treatment in Children with Epilepsy
Guerrini, R., Zaccara, G., la Marca, G., & Rosati, A. (2012) · Drug Safety · doi:10.2165/11630700-000000000-00000 · Cited by 56
Self-citation
Use of complementary and alternative medicine (CAM) by parents in their children and adolescents with epilepsy – Prevelance, predictors and parents' assessment
Hartmann, N., Neininger, M. P., Bernhard, M. K., Syrbe, S., Nickel, P., Merkenschlager, A., Kieß, W., Bertsche, T., & Bertsche, A. (2015) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2015.11.003 · Cited by 56
Drowning fatalities in childhood: the role of pre-existing medical conditions
Franklin, R. C., Pearn, J. H., & Peden, A. E. (2017) · Archives of Disease in Childhood · doi:10.1136/archdischild-2017-312684 · Cited by 56
Predisposing and Causative Factors in Childhood Epilepsy
Nelson, K. B., & Ellenberg, J. H. (1987) · Epilepsia · doi:10.1111/j.1528-1157.1987.tb05750.x · Cited by 56
Fetal heart rate patterns in postasphyxiated fetal lambs with brain damage
Ikeda, T., Murata, Y., Quilligan, E. J., Parer, J. T., Theunissen, I., Cifuentes, P., Doi, S., & Park, S.-D. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70156-5 · Cited by 56
Factors Affecting Epilepsy Development and Epilepsy Prognosis in Cerebral Palsy
Mert, G. G., İncecik, F., Altunbaşak, Ş., Herguner, O. M., Mert, M. K., Kiriş, N., & Ünal, İ. (2011) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2011.03.001 · Cited by 55
Corticosteroids including ACTH for childhood epilepsy other than epileptic spasms
Mehta, V., Ferrie, C. D., Cross, J. H., & Vadlamani, G. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005222.pub3 · Cited by 55
Absence epilepsy: early prognostic signs
Covanis, A., Skiadas, K., Loli, N., Lada, C., & Theodorou, V. (1992) · Seizure · doi:10.1016/1059-1311(92)90038-3 · Cited by 55
Open study of clobazam in refractory epilepsy
Munn, R., & Farrell, K. (1993) · Pediatric Neurology · doi:10.1016/0887-8994(93)90026-9 · Cited by 55
Comparison of antiepileptic drug prescribing in children in three European countries
Hsia, Y., Neubert, A. C., Sturkenboom, M., Murray, M. L., Verhamme, K. M. C., Şen, F., Giaquinto, C., Ceci, A., Wong, I. C. K., & on behalf of the TEDDY Network of Excellence (2009) · Epilepsia · doi:10.1111/j.1528-1167.2009.02331.x · Cited by 54
Malformations of Cortical Development and Aberrant Cortical Networks: Epileptogenesis and Functional Organization
Guerrini, R., & Barba, C. (2010) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0b013e3181fe0585 · Cited by 54
Self-citation
Quantitative structure-activity relationship and molecular docking studies of a series of quinazolinonyl analogues as inhibitors of gamma amino butyric acid aminotransferase
Abdulfatai, U., Uzairu, A., & Uba, S. (2016) · Journal of Advanced Research · doi:10.1016/j.jare.2016.10.004 · Cited by 54
Comparison of sprinkle versus syrup formulations of valproate for bioavailability, tolerance, and preference
Cloyd, J. C., Kriel, R. L., Jones-Saete, C. M., Ong, B. Y., Jancik, J. T., & Remmel, R. P. (1992) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)82496-5 · Cited by 54
Bilateral frontoparietal polymicrogyria, Lennox‐Gastaut syndrome, and GPR56 gene mutations
Parrini, E., Ferrari, A. R., Dorn, T., Walsh, C. A., & Guerrini, R. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01787.x · Cited by 54
Self-citation
Hereditary febrile seizures: Phenotype and evidence for a chromosome 19p locus
Kugler, S. L., Stenroos, E. S., Mandelbaum, D. E., Lehner, T., McKoy, V. V., Prossick, T., Sasvari, J., Swannick, K., Katz, J., & Johnson, W. G. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19981012)79:5 · Cited by 54
Does epilepsy in multiplex autism pedigrees define a different subgroup in terms of clinical characteristics and genetic risk?
Amiet, C., Gourfinkel‐An, I., Laurent‐Levinson, C., Bodeau, N., Génin, B., Leguern, É., Tordjman, S., & Cohen, D. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-47 · Cited by 54
Visual Field Severity Indices Demonstrate Dose‐Dependent Visual Loss from Vigabatrin Therapy
Conway, M. L., Cubbidge, R. P., & Hosking, S. L. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01249.x · Cited by 52
The X‐linked infantile spasms syndrome (Mim 308350) maps to Xp 11.4–Xpter in two pedigrees
Claes, S. J., Devriendt, K., Lagae, L. G., Ceulemans, B., Dom, L., Casaer, P., Raeymaekers, P., Cassiman, J. J., & Fryns, J. P. (1997) · Annals of Neurology · doi:10.1002/ana.410420313 · Cited by 52
High dosage of cannabidiol (CBD) alleviates pentylenetetrazole-induced epilepsy in rats by exerting an anticonvulsive effect.
Mao, K., You, C., Lei, D., & Zhang, H. (2015) · Europe PMC (PubMed Central) · Cited by 51
Novel and Emerging Strategies in Drug Delivery for Overcoming the Blood–Brain Barrier
Stenehjem, D. D., Hartz, A. M. S., Bauer, B., & Anderson, G. W. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.137 · Cited by 53
Personalized medicine in genetic epilepsies – possibilities, challenges, and new frontiers
Helbig, I., & Ellis, C. A. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107970 · Cited by 51
Epidemiology of seizures in children with brain tumors
Gilles, F., Sobel, E. L., Leviton, A., Hedley‐Whyte, E. T., Tavaré, C. J., Adelman, L. S., & Sobel, R. A. (1992) · Journal of Neuro-Oncology · doi:10.1007/bf00172457 · Cited by 51
Prevalence of some risk factors in children with epilepsy compared to their controls
Cansu, A., Serdaroğlu, A., Yüksel, D., Doğan, V., Özkan, S. A., Hırfanoğlu, T., Şenbil, N., Gücüyener, K., Soysal, Ş., Çamurdan, A. D., et al. (2007) · Seizure · doi:10.1016/j.seizure.2007.02.003 · Cited by 50
Benign childhood epilepsy with centrotemporal spikes and the multicomponent model of attention: A matched control study
Cerminara, C., D’Agati, E., Lange, K. W., Kaunzinger, I., Tucha, O. M., Parisi, P., Spalice, A., & Curatolo, P. (2010) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2010.07.008 · Cited by 49
Evaluation of serum lipids and carotid artery intima media thickness in epileptic children treated with valproic acid
Erdemir, A., Çullu, N., Yiş, U., Demircioğlu, F., Kır, M., Çakmakçı, H., Ünal, N., & Dırık, E. (2008) · Brain and Development · doi:10.1016/j.braindev.2008.11.001 · Cited by 49
Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta‐analysis
Rosati, A., Ilvento, L., Lucenteforte, E., Pugi, A., Crescioli, G., McGreevy, K. S., Virgili, G., Mugelli, A., MASI, S. D., & Guerrini, R. (2017) · Epilepsia · doi:10.1111/epi.13981 · Cited by 49
Self-citation
A role of autoimmunity in the etiopathogenesis of Landau-Kleffner syndrome?
Nevšímalová, S., Tauberová, A., Doutlík, S., Kučera, V., & Dlouhá, O. (1992) · Brain and Development · doi:10.1016/s0387-7604(12)80157-4 · Cited by 49
Children with Rolandic spikes and ictal vomiting: Rolandic epilepsy or Panayiotopoulos syndrome?
Covanis, A., Lada, C., & Skiadas, K. (2003) · Epileptic Disorders · doi:10.1684/j.1950-6945.2003.tb00003.x · Cited by 48
Acquired Epileptiform Aphasia: A Dimensional View of Landau-Kleffner Syndrome and the Relation to Regressive Autistic Spectrum Disorders
Stefanatos, G. A., Kinsbourne, M., & Wasserstein, J. (2002) · Child Neuropsychology · doi:10.1076/chin.8.3.195.13498 · Cited by 48
Generalized Tonic–Clonic and Febrile Seizures
Hirtz, D. G. (1989) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(16)36654-8 · Cited by 48
Pharmacological Activity of Pyrazole Derivatives as an Anticonvulsant for Benefit against Epilepsy
Gao, M., Qu, K., Zhang, W., & Wang, X. (2021) · NeuroImmunoModulation · doi:10.1159/000513297 · Cited by 48
Seizure tests distinguish intermittent fasting from the ketogenic diet
Hartman, A. L., Zheng, X., Bergbower, E. A. S., Kennedy, M., & Hardwick, J. M. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02577.x · Cited by 47
Postterm Delivery and Risk for Epilepsy in Childhood
Ehrenstein, V., Pedersen, L. H., Holsteen, V., Larsen, H., Rothman, K. J., & Sørensen, H. T. (2007) · PEDIATRICS · doi:10.1542/peds.2006-1308 · Cited by 47
Prospective study of POLG mutations presenting in children with intractable epilepsy: Prevalence and clinical features
Uusimaa, J., Gowda, V. L., McShane, A., Smith, C., Evans, J., Shrier, A., Narasimhan, M., O'Rourke, A. W., Rajabally, Y. A., Hedderly, T. J., et al. (2013) · Epilepsia · doi:10.1111/epi.12115 · Cited by 47
West syndrome: long-term prognosis and social aspects
Appleton, R. E. (2001) · Brain and Development · doi:10.1016/s0387-7604(01)00264-9 · Cited by 47
Therapeutic drug monitoring of carbamazepine and its metabolite in children from dried blood spots using liquid chromatography and tandem mass spectrometry
Shokry, E., Villanelli, F., Malvagia, S., Rosati, A., Forni, G., Funghini, S., Ombrone, D., Bona, M. D., Guerrini, R., & la Marca, G. (2015) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2015.02.045 · Cited by 46
Self-citation
Effect of war on the occurrence of epileptic seizures in children
Bošnjak, J., Vuković-Bobić, M., & Mejaški‐Bošnjak, V. (2002) · Epilepsy & Behavior · doi:10.1016/s1525-5050(02)00602-9 · Cited by 46
Epileptic and non-epileptic cerebral palsy: EEG and cranial imaging findings
Şenbil, N., Sonel, B., Aydin, Ö. F., & Gürer, Y. K. Y. (2002) · Brain and Development · doi:10.1016/s0387-7604(02)00025-6 · Cited by 46
Epilepsy and learning disabilities—a challenge for the next millennium?
Hannah, J. A., & Brodie, M. J. (1998) · Seizure · doi:10.1016/s1059-1311(98)90002-4 · Cited by 46
Differential effects of perinatal hypoxia and anoxia on long term seizure susceptibility in the rat
Jensen, F. E., Applegate, C. D., Burchfiel, J. L., & LOMBROSO, C. T. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90448-k · Cited by 46
Infantile spasms in the setting of Sturge–Weber syndrome
Barbagallo, M., Ruggieri, M., Incorpora, G., Pavone, P., Nucifora, C., Spalice, A., Praticò, A. D., Polizzi, A., Pavone, L., & Iannetti, P. (2008) · Child s Nervous System · doi:10.1007/s00381-008-0705-6 · Cited by 45
Perceptions, social life, treatment and education gap of Tanzanian children with epilepsy: A community-based study
Mushi, D., Burton, K., Mtuya, C. C., Gona, J. K., Walker, R. W., & Newton, C. R. J. C. (2012) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2011.12.003 · Cited by 46
Maternal Use of Antibiotics, Hospitalisation for Infection during Pregnancy, and Risk of Childhood Epilepsy: A Population-Based Cohort Study
Nørgaard, M., Ehrenstein, V., Nielsen, R. B., Bakketeig, L. S., & Sørensen, H. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030850 · Cited by 45
Clinical predictors of intractable childhood epilepsy
Gururaj, A., Sztriha, L., Hertecant, J., & Eapen, V. (2006) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2006.07.018 · Cited by 45
Use of Second-Generation Antiepileptic Drugs in the Pediatric Population
Chung, A. M., & Eiland, L. S. (2008) · Pediatric Drugs · doi:10.2165/00148581-200810040-00003 · Cited by 45
Symptomatology in children with focal sharp waves of genetic origin
Doose, H. (1989) · European Journal of Pediatrics · doi:10.1007/bf01958285 · Cited by 45
Experimental Neonatal Status Epilepticus and the Development of Temporal Lobe Epilepsy with Unilateral Hippocampal Sclerosis
Dunleavy, M., Shinoda, S., Schindler, C. K., Ewart, C., Dolan, R. D., Gobbo, O. L., Kerskens, C., & Henshall, D. C. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090119 · Cited by 44
Seizure response dogs: Evaluation of a formal training program
Kirton, A., Winter, A., Wirrell, E. C., & Snead, O. C. (2008) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2008.05.011 · Cited by 44
Maternal Body Mass Index in Early Pregnancy and Risk of Epilepsy in Offspring
Razaz, N., Tedroff, K., Villamor, E., & Cnattingius, S. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2016.6130 · Cited by 44
Epilepsy in Tubulinopathy: Personal Series and Literature Review
Romaniello, R., Zucca, C., Arrigoni, F., Bonanni, P., Panzeri, E., Bassi, M. T., & Borgatti, R. (2019) · Cells · doi:10.3390/cells8070669 · Cited by 44
Adjunctive zonisamide therapy in the long‐term treatment of children with partial epilepsy: Results of an open‐label extension study of a phase III , randomized, double‐blind, placebo‐controlled trial
Guerrini, R., Rosati, A., Bradshaw, K., & Giorgi, L. (2014) · Epilepsia · doi:10.1111/epi.12548 · Cited by 43
Self-citation
Maternal Thyroid Dysfunction and Risk of Seizure in the Child: A Danish Nationwide Cohort Study
Andersen, S. L., Laurberg, P., Wu, C. S., & Olsen, J. (2013) · Journal of Pregnancy · doi:10.1155/2013/636705 · Cited by 45
Etiology, syndrome diagnosis, and cognition in childhood‐onset epilepsy: A population‐based study
Sokka, A., Olsén, P., Kirjavainen, J., Harju, M., Keski‐Nisula, L., Räisänen, S., Heinonen, S. T., & Kälviäinen, R. K. (2016) · Epilepsia Open · doi:10.1002/epi4.12036 · Cited by 43
Pharmacokinetics and Drug Interaction of Antiepileptic Drugs in Children and Adolescents
Iapadre, G., Balagura, G., Zagaroli, L., Striano, P., & Verrottı, A. (2018) · Pediatric Drugs · doi:10.1007/s40272-018-0302-4 · Cited by 43
Epileptic Syndromes in Childhood
Aicardi, J. F. (1988) · Epilepsia · doi:10.1111/j.1528-1157.1988.tb05803.x · Cited by 43
Towards a Better Understanding of Cognitive Deficits in Absence Epilepsy: a Systematic Review and Meta-Analysis
Wald, E. L. A. F., Hendriksen, J. G. M., Drenthen, G. S., van Kuijk, S. M. J., Aldenkamp, A. P., Vles, J. S. H., Vermeulen, R. J., Hall, M. H. J. A. D.-V., & Klinkenberg, S. (2019) · Neuropsychology Review · doi:10.1007/s11065-019-09419-2 · Cited by 42
Risk Factors for Idiopathic Generalized Seizures: A Population‐Based Case Control Study in Copparo, Italy
Monetti, V. C., Granieri, E., Casetta, I., Tola, M. R., Paolino, E., Malagù, S., Govoni, V., & Quatrale, R. (1995) · Epilepsia · doi:10.1111/j.1528-1157.1995.tb00988.x · Cited by 42

Authors: Guerrini, R.
Affiliations: University of Pisa (IT)
Corresponding author: Guerrini, Renzo
ORCID: Guerrini, Renzo
Venue: The Lancet
Publisher: Elsevier BV
Published: 2006-02
Volume: 367
Issue: 9509
Pages: 499-524
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(06)68182-8
OpenAlex: W2047243927
Cited by: 848
References: 321
Citations by year: 2026: 15 · 2025: 29 · 2024: 30 · 2023: 27 · 2022: 33 · 2021: 33 · 2020: 21 · 2019: 22 · 2018: 19 · 2017: 20 · 2016: 17 · 2015: 28 · 2014: 26 · 2013: 31 · 2012: 33
FWCI: 4.79
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Florence Research (University of Florence) (submittedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Keywords: pediatric epilepsy, epileptic encephalopathy, perinatal encephalopathy, cortical dysplasia, hippocampal sclerosis, ion channel disorders, benign rolandic epilepsy, antiepileptic drugs, epilepsy surgery, etiology, neuroimaging, EEG diagnosis, cognitive side effects
MeSH terms: Adolescent, Anticonvulsants, Child, Child, Preschool, Epilepsy, Humans, Infant, Infant, Newborn, Prognosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Epilepsy in children

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks